Protein Alignment spas and fignl1

DIOPT Version :9

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001122223.1
• Gene: fignl1 / 569539
• ZFINID: ZDB-GENE-030131-1862
• Length: 661
• Species: Danio rerio
• Alignment Length: 600
• Identity: 198/600 - (33%)
• Similarity: 304/600 - (50%)
• Gaps: 141/600 - (23%)

  Fly   285 DRAQRLHDKMQTNLSMARDRLHFLALREQDLQMQ---RLSLKEKQKEEAQSKPQKTREPMLAGMT 346
            |..:.|::..:|.|.:||::.:.....|..|.::   .||..:|.   .|::......|:
Zfish    70 DPYKGLNNYAETALHLARNQKNHSDKWESSLTLENVFNLSCVQKM---IQARSDGCALPV----- 126

  Fly   347 NEPMKLRVR------------SSGYGPKATTSAQPTASGRKLTI-------GSKRPVN----LAV 388
             :|..:.:.            ||..||.:....:|.|.|..:.:       |...|::    |.|
Zfish   127 -DPADVNISVGGEVSGGGEKGSSLSGPPSGLKQEPLAHGHSVPLPTAEMARGDINPISGSGGLEV 190

  Fly   389 A----NKSQTLPR-----------NLGSK------------TSVGAVQRQPAKTAATPPAVRRQF 426
            |    :.:|..|:           |.||.            ||...|..||...::|.|:.|:.|
Zfish   191 APPRFSLAQNTPKGLTGSTIFGHNNFGSTGNAVVPQSNVACTSRSNVHNQPVFFSSTNPSKRKNF 255

  Fly   427 SSGRNTPPQRSRTP-----------------INNN-------------------GPSGS------ 449
             .|..|...||..|                 |:.|                   |..||
Zfish   256 -YGSGTESSRSSFPSQGEQELRGRGLRGEEGISTNFRSAREQFIVDQQKKHSHQGQRGSPGNVFT 319

  Fly   450 ------------GASTPVVS-----------------------VKGVEQKLVQLILDEIVEGGAK 479
                        |||:..:|                       :|..|.|:::||:.||::.|..
Zfish   320 ITKKCLGANRSRGASSKFISPMPRQEEDLKDNTPKDMQPVDERLKNFEPKIIELIMSEIMDHGPP 384

  Fly   480 VEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATF 544
            |.|.||||.:.||..::|:|:.|.:||::|||||.|.||:|||||||.||||:.:.:|.:..|||
Zfish   385 VAWDDIAGLEFAKATIKEIVVWPMLRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIACQSGATF 449

  Fly   545 LNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVE 609
            .:|||:|||||:||:|||:||||||:||..||::|||||:|||||:|:..||::|||:||||||:
Zfish   450 FSISASSLTSKWVGEGEKMVRALFAIARCHQPAVIFIDEIDSLLSQRTDGEHDSSRRIKTEFLVQ 514

  Fly   610 FDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTE 674
            .||...:.: |||:|:.|||||||:||||.||..||:|:.||:.:.|..::..|:..:.|.|..:
Zfish   515 LDGAATSAE-DRILVVGATNRPQEIDEAARRRLAKRLYIPLPEAEARRQIVTNLMSHEKSQLGVD 578

  Fly   675 ALRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVA 739
            .:.::.:.|:|:||:|:|.|.::|||.|||.:::..:..:....:|.|...||..:||.:|.||:
Zfish   579 EMEKVVQGTEGFSGADMTQLCREAALGPIRSISLSDIATIMAEQVRPILYSDFQEALKTVRPSVS 643

  Fly   740 PQSLNSYEKWSQDYG 754
            .:.|..||:|::.:|
Zfish   644 SKDLELYEEWNKTFG 658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	6/22 (27%)
		P-loop_NTPase	482..>538	CDD:304359	31/55 (56%)
		AAA	515..652	CDD:214640	86/136 (63%)
		AAA	519..650	CDD:278434	82/130 (63%)
		Vps4_C	<722..754	CDD:286426	12/31 (39%)
fignl1	NP_001122223.1	AAA	420..556	CDD:214640	86/136 (63%)
		AAA	424..554	CDD:278434	82/130 (63%)
		Vps4_C	<610..658	CDD:286426	13/47 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1176820at2759
OrthoFinder	1	1.000	-	-		FOG0001088
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100722
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.720