DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spas and AgaP_AGAP009548

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	XP_001688268.1	Gene:	AgaP_AGAP009548 / 5668090	VectorBaseID:	AGAP009548	Length:	617	Species:	Anopheles gambiae

Alignment Length:	373	Identity:	94/373 - (25%)
Similarity:	145/373 - (38%)	Gaps:	118/373 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   460 GVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGP 524
            |.:|::..|              .:|.|.|.....|:|::.:........|.:...::|:||.|.
Mosquito   260 GHQQRMYSL--------------ANIGGLDTTISELKELLEMAFGMDSKQTTVGPVSRGILLSGV 310

  Fly   525 PGNGKTLLARAVAT---------ECSATF--------LNIS------------------------ 548
            .|.|||:|..|:||         .||..|        .|:|
Mosquito   311 SGVGKTMLVNALATHYHCHVVRINCSEVFSKFYGESEANVSRQFAEVFDVHPKPAIVVVEELHNL 375

  Fly   549 --------------------------------------------AASLTSKYVGDGEKLVRALFA 569
                                                        .:.|.|.:||:.|:.||.||.
Mosquito   376 CPKSTATDIVKRISQHFLTLLDSLHANVRGNRTVVIGTTDSVENGSELFSMWVGESERAVRDLFR 440

  Fly   570 VARHMQPSIIFIDEVDSLLSERSS-SEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQE 633
            .||.:.|||||.||:|::..|||: |......|:..:.|.|.||:....|   :.::||||||..
Mosquito   441 RARQVAPSIIFFDEIDAIGGERSAESGSSVKERVLAQLLTEMDGVSVLKD---VRIVAATNRPDL 502

  Fly   634 LDEAALR--RFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAK 696
            :|.|.:|  |..:.|||.|||...||.:. |:..|......|..|..|.:.|.|.|||::.|:.:
Mosquito   503 IDRALMRPGRLDRIVYVRLPDAAAREEIF-RIKLKTIPTASTVDLAELVRRTAGCSGSEIEAICQ 566

  Fly   697 DAALEPIR-ELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSL 743
            :|||:.:. ..:||.::.           :.|..:|..:|...:|:.|
Mosquito   567 EAALKGLESSFDVETIEW-----------EHFEHALGVVRPRTSPELL 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	16/55 (29%)
		AAA	515..652	CDD:214640	60/224 (27%)
		AAA	519..650	CDD:278434	58/218 (27%)
		Vps4_C	<722..754	CDD:286426	5/22 (23%)
AgaP_AGAP009548	XP_001688268.1	AAA_16	273..411	CDD:289934	22/137 (16%)
		AAA	303..523	CDD:214640	60/222 (27%)
		AAA	<419..521	CDD:278434	42/104 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900