DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and zgc:136908

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001035017.1	Gene:	zgc:136908 / 563679	ZFINID:	ZDB-GENE-060312-22	Length:	805	Species:	Danio rerio

Alignment Length:	739	Identity:	177/739 - (23%)
Similarity:	296/739 - (40%)	Gaps:	181/739 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 YSSSVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRP-HRRD----------- 158
            |...:|          ::.:.:.:..|...||.:|...|....   ||| |:.|
Zfish   112 YGKRIH----------VLPIDDTIEGLTGNLFDVFLKPYFLEA---YRPVHKGDIFLVRGGMRAV 163

  Fly   159 ----------------------CNIEIVVQNSSKEQQQSLNHPSELNREG-DGQEQQLS------ 194
                                  |..|.:   ..:::::|||   ::..:. .|..:||:
Zfish   164 EFKVVETDPTPHCIVAPDTIIHCEGEPI---KREDEEESLN---DIGYDDIGGCRKQLAQIKEMV 222

  Fly   195 ----NQPQRFRPIQPLEMAANRPGGGY----SPGPGDPLLAKQKHHHRRAFEYISKALKIDEENE 251
                ..|..|:.|      ..:|..|.    .||.|..|:|:...:...||.::....:|..:..
Zfish   223 ELPLRHPALFKAI------GVKPPRGILLYGPPGTGKTLVARAVANETGAFFFLINGPEIMSKLA 281

  Fly   252 GHKELAIELYRKGIKELE------------DGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDR 304
            |..|..:   ||..:|.|            |.||           .:.::.|.::
Zfish   282 GESESNL---RKAFEEAEKNAPAIIFIDELDAIA-----------PKREKTHGEV---------- 322

  Fly   305 LHFLALREQDLQMQRLSLKEKQKEEAQSKPQKTREPMLAGMTNEP--MKLRVRSSGYGPKATTSA 367
                   |:.:..|.|:|.:..|:.|        ..::...||.|  :...:|..|...:.....
Zfish   323 -------ERRIVSQLLTLMDGLKQRA--------HVVVMAATNRPNSVDAALRRFGRFDREIDIG 372

  Fly   368 QPTASGRKLTIGSKRPVNLAVANKSQTLPRN-----LGSKT--SVGAVQRQPAKTAATPPAVRRQ 425
            .|.::|| |.|       |.:..|:..|..:     :.::|  .|||........||. .|:|::
Zfish   373 IPDSTGR-LEI-------LQIHTKNMKLSEDVDLEQISAETHGHVGADLAALCSEAAL-QAIRKK 428

  Fly   426 FSSGRNTPPQRSRTPINNNGPSGSGASTPVVSVKGVEQKLVQ---LILDEIVEGGAKVEWTDIAG 487
            .          :...:.::.......::..|::...:..|.|   ..|.|.|.....|.|.||.|
Zfish   429 M----------TLIDLEDDSIDADLLNSLAVTMDDFKWALSQSNPSALRETVVEVPHVNWEDIGG 483

  Fly   488 QDVAKQALQEMVILPSVRPELFT--GLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAA 550
            .|..|:.|||:|..|...|:.|.  |: .|::|:|.:||||.||||||:|:|.||.|.|::|...
Zfish   484 LDEVKRELQELVQYPVEYPDKFLKFGM-TPSRGVLFYGPPGCGKTLLAKAIANECQANFVSIKGP 547

  Fly   551 SLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHE---ASRRLKTEFLVEFDG 612
            .|.:.:.|:.|..||.:|..||...|.|:|.||:||:...|.....:   |:.|:..:.|.|.||
Zfish   548 ELLTMWFGESEANVRDVFDKARQAAPCILFFDELDSIAKARGGGAGDAGGAADRVINQILTEMDG 612

  Fly   613 LPGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEA 675
            :....:   :.::.|||||..:|.|.||  |..:.:|:.|||..:|..:|...|:|.....|.:
Zfish   613 MTNKKN---VFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDMPSRTAILRANLRKSPVAKDVD- 673

  Fly   676 LRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCL-------------DISAMRAITEQDF 727
            |..|:|||:|:||:|||.:.:.|....|||....:::..             |...:..|.:..|
Zfish   674 LMYLSKITEGFSGADLTEICQRACKLAIREAIEAEIRAERQRQARKETAMDDDYDPVPEIRKDHF 738

  Fly   728 HSSLKRIRRSVAPQSLNSYEKWSQ 751
            ..:::..||||:...:..||.::|
Zfish   739 EEAMRFARRSVSDNDIRKYEMFAQ 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	13/89 (15%)
		P-loop_NTPase	482..>538	CDD:304359	28/57 (49%)
		AAA	515..652	CDD:214640	54/141 (38%)
		AAA	519..650	CDD:278434	51/135 (38%)
		Vps4_C	<722..754	CDD:286426	9/30 (30%)
zgc:136908	NP_001035017.1	CDC48	27..766	CDD:273521	177/739 (24%)
		CDC48_N	27..109	CDD:280513
		CDC48_2	133..193	CDD:215011	10/65 (15%)
		AAA	243..372	CDD:278434	29/167 (17%)
		AAA	516..649	CDD:278434	51/135 (38%)
		Vps4_C	<731..762	CDD:286426	8/30 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900