Protein Alignment spas and zgc:136908

DIOPT Version :10

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001035017.1
• Gene: zgc:136908 / 563679
• ZFINID: ZDB-GENE-060312-22
• Length: 805
• Species: Danio rerio
• Alignment Length: 708
• Identity: 174/708 - (24%)
• Similarity: 297/708 - (41%)
• Gaps: 159/708 - (22%)

  Fly   110 VHKQNLYVVSFPIIFLFNVLRSLIYQL-------FCIFRYLYGASTKVIYRPHRRDCNIEIVVQN 167
            |||.::::|.       ..:|::.:::       .||.     |...:|:      |..|.:
Zfish   148 VHKGDIFLVR-------GGMRAVEFKVVETDPTPHCIV-----APDTIIH------CEGEPI--- 191

  Fly   168 SSKEQQQSLNHPSELNREG-DGQEQQLS----------NQPQRFRPIQPLEMAANRPGGGY---- 217
            ..:::::|||   ::..:. .|..:||:          ..|..|:.|      ..:|..|.
Zfish   192 KREDEEESLN---DIGYDDIGGCRKQLAQIKEMVELPLRHPALFKAI------GVKPPRGILLYG 247

  Fly   218 SPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELE------------D 270
            .||.|..|:|:...:...||.::....:|..:..|..|..:   ||..:|.|            |
Zfish   248 PPGTGKTLVARAVANETGAFFFLINGPEIMSKLAGESESNL---RKAFEEAEKNAPAIIFIDELD 309

  Fly   271 GIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREQDLQMQRLSLKEKQKEEAQSKPQ 335
            .||           .:.::.|.::                 |:.:..|.|:|.:..|:.|
Zfish   310 AIA-----------PKREKTHGEV-----------------ERRIVSQLLTLMDGLKQRA----- 341

  Fly   336 KTREPMLAGMTNEP--MKLRVRSSGYGPKATTSAQPTASGRKLTIGSKRPVNLAVANKSQTLPRN 398
               ..::...||.|  :...:|..|...:......|.::|| |.|       |.:..|:..|..:
Zfish   342 ---HVVVMAATNRPNSVDAALRRFGRFDREIDIGIPDSTGR-LEI-------LQIHTKNMKLSED 395

  Fly   399 -----LGSKT--SVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGASTPVV 456
                 :.::|  .|||........||. .|:|::.          :...:.::.......::..|
Zfish   396 VDLEQISAETHGHVGADLAALCSEAAL-QAIRKKM----------TLIDLEDDSIDADLLNSLAV 449

  Fly   457 SVKGVEQKLVQ---LILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFT--GLRAPA 516
            ::...:..|.|   ..|.|.|.....|.|.||.|.|..|:.|||:|..|...|:.|.  |: .|:
Zfish   450 TMDDFKWALSQSNPSALRETVVEVPHVNWEDIGGLDEVKRELQELVQYPVEYPDKFLKFGM-TPS 513

  Fly   517 KGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFI 581
            :|:|.:||||.||||||:|:|.||.|.|::|....|.:.:.|:.|..||.:|..||...|.|:|.
Zfish   514 RGVLFYGPPGCGKTLLAKAIANECQANFVSIKGPELLTMWFGESEANVRDVFDKARQAAPCILFF 578

  Fly   582 DEVDSLLSERSSSEHE---ASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALR--R 641
            ||:||:...|.....:   |:.|:..:.|.|.||:....:   :.::.|||||..:|.|.||  |
Zfish   579 DELDSIAKARGGGAGDAGGAADRVINQILTEMDGMTNKKN---VFIIGATNRPDIIDPAILRPGR 640

  Fly   642 FTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIREL 706
            ..:.:|:.|||..:|..:|...|:|.....|.: |..|:|||:|:||:|||.:.:.|....|||.
Zfish   641 LDQLIYIPLPDMPSRTAILRANLRKSPVAKDVD-LMYLSKITEGFSGADLTEICQRACKLAIREA 704

  Fly   707 NVEQVKCL-------------DISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKWSQ 751
            ...:::..             |...:..|.:..|..:::..||||:...:..||.::|
Zfish   705 IEAEIRAERQRQARKETAMDDDYDPVPEIRKDHFEEAMRFARRSVSDNDIRKYEMFAQ 762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	13/89 (15%)
		RecA-like_spastin	484..648	CDD:410932	65/170 (38%)
		AAA_lid_3	676..727	CDD:465537	17/63 (27%)
		Vps4_C	<722..754	CDD:462762	9/30 (30%)
zgc:136908	NP_001035017.1	CDC48	27..766	CDD:273521	174/708 (25%)