Protein Alignment spas and fignl2

DIOPT Version :9

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001201837.1
• Gene: fignl2 / 561837
• ZFINID: ZDB-GENE-090313-189
• Length: 684
• Species: Danio rerio
• Alignment Length: 864
• Identity: 185/864 - (21%)
• Similarity: 295/864 - (34%)
• Gaps: 335/864 - (38%)

  Fly    10 SSSASSSSTKSPIKSSSGAGS--------------------------SG---------------- 32
            ||:.||.:.||.:.||.|.||                          ||
Zfish    34 SSTTSSPAHKSELYSSRGRGSYSYAWANDDISALTASNLLKRYAEKYSGMLDSPYERPSVGAYPE 98

  Fly    33 ----GGLGGRQ----------------------STHRSSSASNVAAVVAG----GSSAAGGGSSS 67
                |||.|.|                      |:|.|.|...|....||    |:.:|...:.|
Zfish    99 PGAFGGLNGGQKSELEPWPLTHSTDGAYSLVPPSSHESLSGPKVVPTSAGPPGSGNVSAVNSNLS 163

  Fly    68 NRRSPGSSPDGDDDTTTTDDLTPTTCS-PRSGHH-HSYGGY----------SSSVHKQNL----- 115
            :....|||                :|| |.|..: .||.|.          ||::...:|
Zfish   164 DSGYSGSS----------------SCSGPHSSEYPPSYNGTYLSSGYCPQPSSALPPASLHALQP 212

  Fly   116 -------YVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQNSSKEQQ 173
                   |..:.|:                   |.|..||    .||:...             .
Zfish   213 NPTLLPSYTTTAPV-------------------YNYPPST----YPHQTGL-------------A 241

  Fly   174 QSLNHPSELNREGDGQEQQLSNQPQRFRPIQPLEMAANRP---GGGY-----SPG---PGDPLLA 227
            .|..||:                    .|..|..: .:||   ||.|     |.|   ||..|
Zfish   242 PSYTHPT--------------------APYIPSPL-PSRPTVVGGSYGYQNSSVGGSEPGGSL-- 283

  Fly   228 KQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHD 292
                 .|:|||     :.:|||:.....     |||
Zfish   284 -----KRKAFE-----MTLDEEDSDSSR-----YRK----------------------------- 304

  Fly   293 KMQTNLSMARDRLHFLALREQDLQMQRLSLKEKQKEEAQSKPQKTREPMLAGMTNEPMKLRVRSS 357
                                                                .:.:|||    :.
Zfish   305 ----------------------------------------------------YSYDPMK----TG 313

  Fly   358 GYGPKATTSAQPTASGRKLTIGSKRPVNLAVANKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAV 422
            |..|...|.    .:|.....||..|....        |....|::|:..  .:..|.:...|.|
Zfish   314 GDSPYGVTD----KAGNGFGTGSTDPQGFK--------PSKPSSQSSLEG--DEVGKYSGLKPLV 364

  Fly   423 RRQFSSGRNTPPQRSRTPINNNGPSG------SGASTPVVSVKGVEQKLVQLILDEIVEGGAKVE 481
            ...:.:..:..|..:.|..|.....|      ...|.|   :|.:|.::::|:..|:.:....:.
Zfish   365 SPTYGAAGDYSPPAAMTGENGGAEQGFSQNRSQKRSDP---MKSIEPRMLELVSRELQDCSPAML 426

  Fly   482 WTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLN 546
            ||::||....|.||:|.::.|.:||   .....|.|.:|||||.|.|||.|||:::::..|:|..
Zfish   427 WTELAGNCHIKAALEEDLLWPVLRP---NPAIHPPKTILLFGPQGGGKTTLARSLSSQIGASFYR 488

  Fly   547 ISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFD 611
            :|.|:|.||..|:.|:|:..||:||...||:::.:.||:::       |.|.   |:.:...:.:
Zfish   489 LSCATLASKLKGEAEQLLLTLFSVATARQPAMVLLSEVEAI-------EEEG---LRQQLQAQLE 543

  Fly   612 GLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEAL 676
            .:..| ..::.:|:..|.||..:.::.||.|:||.::.|||..||..:|.:.|..||..|....|
Zfish   544 KIQHN-QSNQFLVVCTTRRPDLIKDSLLRCFSKRYHIGLPDGNTRRHVLLQALAPQGCSLSEREL 607

  Fly   677 RRLAKITDGYSGSDLTALAKDA-------ALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRI 734
            ..:.:.::|:|..:|..|.:.|       |..|:..|.         :::.:.|.|||.::..::
Zfish   608 SAVLQRSEGFSVWELLQLCQQALASASASASVPLHSLP---------ASLSSPTLQDFENAFCKV 663

  Fly   735 RRSVAPQSLNSYEKWSQDY 753
            |....|:.|::..:||:.|
Zfish   664 RPHSTPKELDTCMEWSKVY 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	10/77 (13%)
		P-loop_NTPase	482..>538	CDD:304359	25/55 (45%)
		AAA	515..652	CDD:214640	46/136 (34%)
		AAA	519..650	CDD:278434	43/130 (33%)
		Vps4_C	<722..754	CDD:286426	10/32 (31%)
fignl2	NP_001201837.1	AAA	457..583	CDD:214640	46/136 (34%)
		AAA	461..581	CDD:278434	43/130 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810