DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spas and nsfb

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001019625.2	Gene:	nsfb / 554200	ZFINID:	ZDB-GENE-050808-1	Length:	747	Species:	Danio rerio

Alignment Length:	341	Identity:	95/341 - (27%)
Similarity:	152/341 - (44%)	Gaps:	68/341 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   459 KGVEQKLV--QLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLL 521
            ||..|.::  ....:.:..||...|::||     .::|....|..|.:..::  |.: ..||:||
Zfish   202 KGSRQSIINPDWNFERMGIGGLDKEFSDI-----FRRAFASRVFPPDIVEQM--GCK-HVKGILL 258

  Fly   522 FGPPGNGKTLLARAVATECSATFLN------ISAASLTSKYVGDGEKLVRALFAVARHMQP---- 576
            :||||.||||:||.:     ...||      ::...:.:||||:.|..:|.|||.|...|.
Zfish   259 YGPPGCGKTLMARQI-----GKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQKRLGA 318

  Fly   577 ----SIIFIDEVDSLLSER-----SSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQ 632
                .||..||:|::..:|     |:..|:.   :..:.|.:.||:   ...:.|:|:..||||.
Zfish   319 NSGLHIIIFDEIDAICKQRGSMAGSTGVHDT---VVNQLLSKIDGV---EQLNNILVIGMTNRPD 377

  Fly   633 ELDEAALR--RFTKRVYVSLPDEQTRELLLN--RLLQKQGSPLDTEA-LRRLAKITDGYSGSDLT 692
            .:|||.||  |...::.:.||||..|..:||  ....||.:.|..:. ::.||..|..|||::|.
Zfish   378 LIDEALLRPGRLEVKMEIGLPDETGRVQILNIHTAKMKQSNMLAKDVDVKELAVETKNYSGAELE 442

  Fly   693 ALAKDAALEPIR---------ELNVEQVKCLDISAMRAITEQDFHSSLKR--------IRRSVAP 740
            .|.:.|....:.         |::.|:.:.|.:|      ..||.:||..        .:...:.
Zfish   443 GLVRAAQSTAMNRHIKATTQVEVDTEKAQTLQVS------RSDFLASLNNDIKPAFGSNQEDYSS 501

  Fly   741 QSLNSYEKWSQDYGDI 756
            ..:|...|||....||
Zfish   502 YIMNGIVKWSNAVSDI 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	20/55 (36%)
		AAA	515..652	CDD:214640	51/157 (32%)
		AAA	519..650	CDD:278434	48/151 (32%)
		Vps4_C	<722..754	CDD:286426	8/39 (21%)
nsfb	NP_001019625.2	CDC48_N	5..85	CDD:308138
		CDC48_2	111..183	CDD:215011
		SpoVK	<220..490	CDD:223540	86/294 (29%)
		AAA	538..670	CDD:214640
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900