Protein Alignment spas and fign

DIOPT Version :10

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: XP_021334341.1
• Gene: fign / 553599
• ZFINID: ZDB-GENE-050522-339
• Length: 747
• Species: Danio rerio
• Alignment Length: 842
• Identity: 198/842 - (23%)
• Similarity: 344/842 - (40%)
• Gaps: 246/842 - (29%)

  Fly     6 NQSSSSSASSSSTKSPIKSSSG--------------AGSSGGGLGGRQSTH---------RSSSA 47
            |...|:..:|:..|...:..||              :.|:.|.|.||:|..         .|.:|
Zfish    56 NDDISALTASNLLKKYAEKYSGILEGPSERALLCSYSESAPGLLNGRKSESDAWQEGIYPMSCAA 120

  Fly    48 SNVAAVVAGGSSA-------AGGGSSSNRRSPGSSPDGDDDTTTTDDLTPTTCSPRSGHHHSYGG 105
            ..::|...|.:.|       |..|||:...|..|.|          ..:.:.|          |.
Zfish   121 DVISASKTGMTPALPPPDVTASVGSSTGVASSLSEP----------SYSSSNC----------GN 165

  Fly   106 YSSSVHK---QNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQ- 166
            ::|::|.   ...:..|:...:|.:.             |..|.||..:..||....:...::|
Zfish   166 HASALHSGIPSQEFASSYNGSYLHST-------------YSGGQSTPALPSPHPSPLHSAGLLQP 217

  Fly   167 ------------NSSKEQQQSLNHPSELNREGDGQEQQLSNQPQRFRPIQPLEMAANRPGGGYSP 219
                        |:|.....|.|:|                 |..:.|..|:       ..||||
Zfish   218 PPPPPPTLVPSYNTSSPNLSSYNYP-----------------PAGYPPQTPV-------APGYSP 258

  Fly   220 GPGDPLLA---------------------KQKHHH-----------------RRAFEYISKALKI 246
            |...|..|                     .|.|:|                 |:|| |:
Zfish   259 GGAPPPSAYLPSGIAAPTPLPPSTIPGYSYQSHNHAPIAPTPLNGSSANTLKRKAF-YM------ 316

  Fly   247 DEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALR 311
                                           :|:||:        |....|.:.:
Zfish   317 -------------------------------TGQGDM--------DSSYGNFNYS---------- 332

  Fly   312 EQDLQMQRLSLKEKQKEEAQSKPQKTREPMLAGMTNEPMKLRVRSSGYGPKATTS---------A 367
                          |:..|||...:..:..|...|        |.:|:...|.||         :
Zfish   333 --------------QQRSAQSPMYRMPDNSLVDST--------RGNGFDRNADTSSLAFKPTKQS 375

  Fly   368 QPTASGRKLTIGSKRPVNLAVANKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNT 432
            .||...||  .||:       |.::.|.|....||.|:|:::...:......|.:.......|..
Zfish   376 MPTDQQRK--FGSQ-------AGRALTPPSYGSSKGSLGSMRSGESFGKFGSPVMSDHGDDSRQH 431

  Fly   433 PPQRSRTPINNNGPSGSGASTPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQE 497
            .|....|..:::.|:..       .:|..:..||:::..||::....|:|:||||.::||..:::
Zfish   432 LPHSIGTATSSSHPAEE-------QLKNSDASLVEMVTTEILQQTPPVDWSDIAGLEMAKATIKD 489

  Fly   498 MVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEK 562
            .|:.|.:||::|:||....:.:|||||.|.|:|||.|.:|::..|.||.:|.::|.:|::|:|||
Zfish   490 EVLWPILRPDMFSGLATLPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLGEGEK 554

  Fly   563 LVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAA 627
            :|:|.|.:||..|||::||.:||.|||.:.|.|...: |:|:|.|::.||:..:|: :.::|:.:
Zfish   555 IVQASFLIARCRQPSVVFISDVDLLLSSQLSEESPVN-RIKSELLLQLDGVLSSPE-EHVLVVCS 617

  Fly   628 TNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLT 692
            |::|:|:||:..|.|.||:.|.|||...|..::::||.:....|..:.:..|.:.|||:||.|:.
Zfish   618 TSKPEEIDESLRRYFVKRLLVPLPDATARHQIISQLLSQHNYCLSDKEVTLLVQRTDGFSGLDVV 682

  Fly   693 ALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDYG 754
            .|.::|.:.|:..:....:..:....||.::.|||.:...:|:.|::.:.|::|.:|::.:|
Zfish   683 RLCQEALVGPLHGMPGADLSGMIPGQMRPVSYQDFENVFCKIQPSISQKELDTYTEWNKMFG 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	11/94 (12%)
		RecA-like_spastin	484..648	CDD:410932	69/163 (42%)
		AAA_lid_3	676..727	CDD:465537	13/50 (26%)
		Vps4_C	<722..754	CDD:462762	8/31 (26%)
fign	XP_021334341.1	PHA03378	<174..300	CDD:223065	27/162 (17%)
		RecA-like_fidgetin	476..638	CDD:410931	69/163 (42%)
		AAA_lid_3	669..>694	CDD:465537	10/24 (42%)
		Vps4_C	<711..744	CDD:462762	8/32 (25%)