Protein Alignment spas and drc11

DIOPT Version :10

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: XP_073809094.1
• Gene: drc11 / 553364
• ZFINID: ZDB-GENE-050208-768
• Length: 846
• Species: Danio rerio
• Alignment Length: 698
• Identity: 153/698 - (21%)
• Similarity: 255/698 - (36%)
• Gaps: 196/698 - (28%)

  Fly   138 CIFRYLYGASTKVIYRPHRR---DCNIEIVVQNSSKEQQQSLNHPSELNREGDGQEQQLSNQPQR 199
            ||.:...|      ||..||   :|..|::.......|||:.: |::|.          :.|.:|
Zfish   211 CIQKVWRG------YRDRRRVNKECLEEMIFLGMIPAQQQTPS-PAQLR----------AQQVER 258

  Fly   200 FRPIQPLEMAANRPGGGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDE-----ENEGHKELAIE 259
            .|.|                        .|:.|..   ||.:..:.|.|     :....||...|
Zfish   259 RRHI------------------------IQEEHEA---EYQTALVNIKESVRTVDGADIKESLQE 296

  Fly   260 LYRKGIKELEDGIAVDCWSGR----------GDVWDRAQRLHDKMQTNLSMARDRLHFLALREQD 314
            ..|:...|..|.      ||:          |.....||:..:::...          .|.:|::
Zfish   297 QIRQWFLECRDA------SGKFPDFPSPEDGGSASIFAQKTPEQVAAE----------FAAKEEE 345

  Fly   315 LQMQRLSLKEKQKEEAQSKPQKTREPMLAGMTNEPMKLRVRSSGYGPKATTSAQPTASGRKLTIG 379
            .:.::....||.|:....|.:|..:|                .|.|.|..|..:.|  |.|:|..
Zfish   346 REKKKKLKSEKDKKANDRKEKKKGKP----------------KGKGGKGDTEEEET--GWKMTPS 392

  Fly   380 SKRPV-------------------------NLAVANKSQTLPRNLGSKTSVGAVQRQPAKT---- 415
            :..|.                         :..:..:.:.|...:..:..|..:.||..|.
Zfish   393 NFLPTVFEGAKLYKEVWQNRDEQQNFLQRFDAQLVREEKRLEVEVELRVQVDELMRQELKNLKLV 457

  Fly   416 ---------AATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGASTPVVSVKGVEQKLVQLILD 471
                     .....:.:::...||.|..::.:            ....:.:.:.:|....:|:|:
Zfish   458 VDRDKGKKKKKVKKSSKKKKKKGRKTGKKKKK------------KEKDLTADRTIESLYEELVLE 510

  Fly   472 EIVEGGAKVEWTDIAGQ-----DVAKQA-LQEMVILPSVRPEL-FTGL----------RAP-AKG 518
            .|:.....|:.:|..|:     ...:|| ::.|..|..||..: ..|:          |.| .:.
Zfish   511 GIIIRPMNVKLSDYIGEYSYLGTTLRQADIEPMPSLSDVRQLIALYGILPLGSQCVHERGPLIRA 575

  Fly   519 LLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDG--EKLVRALFAVARHMQPSIIFI 581
            |||.||.|.||.:|..|:.||..|...|:|.::|..||.|..  :.|:..:|.|||.:|||:|:|
Zfish   576 LLLTGPQGVGKKMLVHALCTETGANLFNLSPSTLAGKYPGKSGLQLLLHMVFKVARQLQPSVIWI 640

  Fly   582 DEVDSLLSE---RSSSEHEASRRLKTEFLVEFDGLP----GNPDGDRIVVLAATNRPQELD-EAA 638
            .:.:....:   :...|.|..|..||        ||    .....||::|:..:.||.:.| :..
Zfish   641 GDAEKTFYKKVPKLEKEMEPKRLKKT--------LPKILKSIKAEDRVLVVGTSRRPFDADIKPF 697

  Fly   639 LRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEA-LRRLAKITDGYS-GSDLTALAKDAALE 701
            .:.:.|.:.:..||..:|..|...|||..|:.||.:. |..|||:||||: |..|.|:  ...|.
Zfish   698 CKVYKKIILIPRPDYASRFTLWKELLQAHGALLDPKLDLSSLAKVTDGYTQGHILQAI--QTILI 760

  Fly   702 PIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKW 749
            |.|         |::.|.|.:|..:|...|.| :..|..:...|::.|
Zfish   761 PHR---------LELQAKRPLTAVEFIPPLAR-QDPVYKEEEESFKAW 798

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	16/92 (17%)
		RecA-like_spastin	484..648	CDD:410932	54/191 (28%)
		AAA_lid_3	676..727	CDD:465537	18/51 (35%)
		Vps4_C	<722..754	CDD:462762	7/28 (25%)
drc11	XP_073809094.1	None