Protein Alignment spas and FIGN

DIOPT Version :9

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: XP_011509691.1
• Gene: FIGN / 55137
• HGNCID: 13285
• Length: 785
• Species: Homo sapiens
• Alignment Length: 801
• Identity: 192/801 - (23%)
• Similarity: 313/801 - (39%)
• Gaps: 228/801 - (28%)

  Fly     9 SSSSASSSSTKSPIKSSSGAGSSGGGLGGRQSTHRSSS---ASNVAAVVAGGSS---AAGGGSSS 67
            ::|.|..||...|...|:..|||.|..........|||   :..|.::.||..|   |.|...|.
Human   155 TASKAGVSSALPPADVSASIGSSPGVASNLTEPSYSSSTCGSHTVPSLHAGLPSQEYAPGYNGSY 219

  Fly    68 NRRSPGSSPDGDDDTTTTDDLTPTTCSPRSGHHHSYG----------------GYSSSVHKQNLY 116
            ...:..|.|            .|...||.....||.|                ||:.:   .||.
Human   220 LHSTYSSQP------------APALPSPHPSPLHSSGLLQPPPPPPPPPALVPGYNGT---SNLS 269

  Fly   117 VVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQNSSKEQQQSLNHPSE 181
            ..|:|                                                     |.::|
Human   270 SYSYP-----------------------------------------------------SASYP-- 279

  Fly   182 LNREGDGQEQQLSNQPQRFRPIQPLEMAANRPGGGYSPGPGDPLLAKQKHHHRRAFEYISKALKI 246
                           ||            ...|.|||||...|          ....|:...:..
Human   280 ---------------PQ------------TAVGSGYSPGGAPP----------PPSAYLPSGIPA 307

  Fly   247 DE----------ENEGH-----------KELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRL 290
            ..          ..:||           ...|..|.||..          ..:|:||:
Human   308 PTPLPPTTVPGYTYQGHGLTPIAPSALTNSSASSLKRKAF----------YMAGQGDM------- 355

  Fly   291 HDKMQTNLSMARDRLHFLALREQDLQMQRLSLKEKQKEEAQSKPQKTREPMLAGMTNEPMKLRVR 355
             |....|.|..:.|                               .|:.||.. |.:..:....|
Human   356 -DSSYGNYSYGQQR-------------------------------STQSPMYR-MPDNSISNTNR 387

  Fly   356 SSGYGPKATTSAQPTASGRKLTIGSKRPVNLAVANKSQTLPRNLGSKTSVGAVQRQPAKTAATPP 420
            .:|:...|.||:......::|....::....:.::::.|.|....:|.|:|:
Human   388 GNGFDRSAETSSLAFKPTKQLMSSEQQRKFSSQSSRALTPPSYSTAKNSLGS------------- 439

  Fly   421 AVRRQFSSGRNTPPQRSR----------TPINNNGPSGSGASTPVV--SVKGVEQKLVQLILDEI 473
              |...|.|:.|.|..|.          .|:...|...:.:|...|  .:|..:..|:.|:.:||
Human   440 --RSSESFGKYTSPVMSEHGDEHRQLLSHPMQGPGLRAATSSNHSVDEQLKNTDTHLIDLVTNEI 502

  Fly   474 VEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVAT 538
            :..|..|:|.||||.|:.|..::|.|:.|.:|.:.|:||.|..:.:|||||.|.|||||.|.:|:
Human   503 ITQGPPVDWNDIAGLDLVKAVIKEEVLWPVLRSDAFSGLTALPRSILLFGPRGTGKTLLGRCIAS 567

  Fly   539 ECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLK 603
            :..|||..|:.:.|.:|::|:.||::.|.|.|||..|||:||:.::|.|||.:.:.||....|::
Human   568 QLGATFFKIAGSGLVAKWLGEAEKIIHASFLVARCRQPSVIFVSDIDMLLSSQVNEEHSPVSRMR 632

  Fly   604 TEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQG 668
            ||||::.|.:..:.: |:|||:.||::|:|:||:..|.|.||:.:.|||...|..::.:||.:..
Human   633 TEFLMQLDTVLTSAE-DQIVVICATSKPEEIDESLRRYFMKRLLIPLPDSTARHQIIVQLLSQHN 696

  Fly   669 SPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKR 733
            ..|:.:....|.:.|:|:||.|:..|.::|.:.|:..:....:..:..|.:|.:|.|||.::..:
Human   697 YCLNDKEFALLVQRTEGFSGLDVAHLCQEAVVGPLHAMPATDLSAIMPSQLRPVTYQDFENAFCK 761

  Fly   734 IRRSVAPQSLNSYEKWSQDYG 754
            |:.|::.:.|:.|.:|::.:|
Human   762 IQPSISQKELDMYVEWNKMFG 782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	14/98 (14%)
		P-loop_NTPase	482..>538	CDD:304359	27/55 (49%)
		AAA	515..652	CDD:214640	59/136 (43%)
		AAA	519..650	CDD:278434	58/130 (45%)
		Vps4_C	<722..754	CDD:286426	9/31 (29%)
FIGN	XP_011509691.1	AAA	545..680	CDD:214640	59/135 (44%)
		AAA	548..678	CDD:278434	58/130 (45%)
		Vps4_C	<749..782	CDD:286426	9/32 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1176820at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820