Protein Alignment spas and spast

DIOPT Version :9

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: XP_012818464.1
• Gene: spast / 549207
• XenbaseID: XB-GENE-947839
• Length: 603
• Species: Xenopus tropicalis
• Alignment Length: 663
• Identity: 309/663 - (46%)
• Similarity: 404/663 - (60%)
• Gaps: 114/663 - (17%)

  Fly   109 SVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQNSSKEQQ 173
            |:||:|||:.|:|::..|::||.|.:||..:|.:.       ..|..||     ::....|...:
 Frog    42 SLHKRNLYLFSYPLLAAFSLLRFLAFQLGLLFVWF-------CERLSRR-----VMADKGSTAAR 94

  Fly   174 QSLNHPSELNREGDGQEQQLSNQPQRFRPIQPLEMAANRPGGGYSPGPGDPLLAKQKHHHRRAFE 238
            .:.                   .|.:.||.:| |:.                    :.:|::||:
 Frog    95 TAA-------------------APAQDRPQEP-EVV--------------------RSYHQQAFQ 119

  Fly   239 YISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARD 303
            |||.||:||||.:..||.||:.|:|||:|||.||||.. :|:|:.:|||:||..||.|||.||:|
 Frog   120 YISMALRIDEEEKDQKEQAIQWYKKGIEELEKGIAVTI-TGKGEQYDRARRLQAKMSTNLLMAKD 183

  Fly   304 RLHFLALREQDLQMQRLSLKEKQKEEAQSKPQKTREPMLAGMTNEPMK--LRVRSSGYGPKATTS 366
            ||..||..:.|:|.|...::                 :.:..||.|.:  |.....|..||   .
 Frog   184 RLQLLAKLKADIQGQHSQME-----------------VCSDNTNLPCRNGLLKPEKGAVPK---K 228

  Fly   367 AQPTASGRKLTIGSKRPVNLAVANKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRN 431
            ..|.      :|.|.....:..|.||.:|...:.:.|.|.:..||                :|.|
 Frog   229 KDPP------SISSNSYSRVKAAPKSGSLGNRIPNCTGVSSSARQ----------------AGPN 271

  Fly   432 TPPQRSRTPINN---NGPSGSGASTPVVSV--------KGVEQKLVQLILDEIVEGGAKVEWTDI 485
            .|..|.....||   |.|     :||..:|        :.|:..|..|||:|||:.|..|::.||
 Frog   272 APSNRGAAGKNNTRTNKP-----TTPTTAVRKKDMKNLRNVDSNLANLILNEIVDSGPTVKFADI 331

  Fly   486 AGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAA 550
            ||||:|||||||:|||||:||||||||||||:|||||||||||||:||:|||.|.:|||.|||||
 Frog   332 AGQDLAKQALQEIVILPSIRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAA 396

  Fly   551 SLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPG 615
            ||||||||:|||||||||:|||.:||||||||||||||.||...||:||||||||||:||||:..
 Frog   397 SLTSKYVGEGEKLVRALFSVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQS 461

  Fly   616 NPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLA 680
            ..| ||::|:.|||||||||:|.|||||||||||||:|:||.|||..||.|||:||:.:.|.:|:
 Frog   462 GGD-DRVLVMGATNRPQELDDAVLRRFTKRVYVSLPNEETRLLLLKNLLSKQGNPLNEKELTQLS 525

  Fly   681 KITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNS 745
            ::|:||||||:|||||||||.|||||..||||.:..|.||.|...||.||||:|:.||:|.:|.|
 Frog   526 RLTEGYSGSDITALAKDAALGPIRELKPEQVKNMAASEMRNIKYSDFLSSLKKIKCSVSPSTLES 590

  Fly   746 YEKWSQDYGDITI 758
            |.:|::::||.|:
 Frog   591 YIRWNKEFGDTTV 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	44/77 (57%)
		P-loop_NTPase	482..>538	CDD:304359	47/55 (85%)
		AAA	515..652	CDD:214640	107/136 (79%)
		AAA	519..650	CDD:278434	102/130 (78%)
		Vps4_C	<722..754	CDD:286426	15/31 (48%)
spast	XP_012818464.1	MIT_spastin	110..188	CDD:239142	44/98 (45%)
		SpoVK	<278..584	CDD:223540	205/311 (66%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	203	1.000	Domainoid score	I2908
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8970
Inparanoid	1	1.050	495	1.000	Inparanoid score	I1356
OMA	1	1.010	-	-		QHG48730
OrthoDB	1	1.010	-	-		D1176820at2759
OrthoFinder	1	1.000	-	-		FOG0001088
OrthoInspector	1	1.000	-	-		oto104767
Panther	1	1.100	-	-	LDO	PTHR23074
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2807
SonicParanoid	1	1.000	-	-		X3342
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110