DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and ATAD2B

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	XP_011531220.1	Gene:	ATAD2B / 54454	HGNCID:	29230	Length:	1511	Species:	Homo sapiens

Alignment Length:	813	Identity:	196/813 - (24%)
Similarity:	311/813 - (38%)	Gaps:	218/813 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVRTKNQSSSSSASSSSTKSPIKSSSGAGSSGGGLGGRQSTH------RSSS--ASNVAAVVAGG 57
            ||.|:..|.....|.|....|   ..|||:..|..||  |:|      |||.  |::..|..|||
Human     1 MVNTRKSSLRLLGSKSPGPGP---GPGAGAEPGATGG--SSHFISSRTRSSKTRAASCPAAKAGG 60

  Fly    58 SSAAGGGSSSNRRSPGSSPDGDDDTTTTDDLTPTTCSPRSGHHHSYGGYSSSVHKQNLYVVSFPI 122
            |..||                    .|.|:....          ...|..|..|      ||.|
Human    61 SGGAG--------------------VTLDEARKV----------EVDGSLSDSH------VSPP- 88

  Fly   123 IFLFNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQNSSKEQQQSLNHPSELNREGD 187
                                    :.:.:.:|       :.|.::.||  .:|.....|.|. ..
Human    89 ------------------------AKRTLKQP-------DSVCKDKSK--SRSTGQREEWNL-ST 119

  Fly   188 GQEQQLSNQPQRFRP---------IQPLEMAANRPGGGYSPGPGDPLLAKQKHHHRRAFEYISKA 243
            || .:|::||....|         ..||. ...:..|..|...||..:.|.....:..||.::::
Human   120 GQ-ARLTSQPGATLPNGHSGLSLRSHPLR-GEKKGDGDLSCINGDMEVRKSCRSRKNRFESVNQS 182

  Fly   244 LKIDE-ENEGHKELAIELYRKGIK------ELEDGIAVDCWSG----RGDVWDRAQRLHDKMQTN 297
            |..|: .|...:.:..|:....|:      |:|   .:..|:.    ..|::.|.:|....::.|
Human   183 LLFDQLVNSTAEAVLQEMDNINIRRNRRSGEVE---RLRMWTDTEFENMDMYSRVKRRRKSLRRN 244

  Fly   298 LSMARDRLHFLALREQD-------LQMQRLSLKEKQK------EEA------------------- 330
             |......|.::...::       |.::::|::.:::      |||
Human   245 -SYGIQNHHEVSTEGEEEARTSKLLPLEKISIESQEEDGDIEVEEAEGEENDRPYNLRQRKTVDR 308

  Fly   331 -QSKP-----QKTREPMLAGMTNEPMKLRVRSSGYGPKATTSAQPTASGRKLTIGSKRPVNLAVA 389
             |:.|     ||.||..|..:...|.:   ||.....|....:..|.|..:.....::..::|.|
Human   309 YQAPPIVPAHQKKRENTLFDIHRSPAR---RSHIRRKKHAIHSSDTTSSDEERFERRKSKSMARA 370

  Fly   390 NKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGASTP 454
             :::.||.|..::.....:.|:..|.                                  |||..
Human   371 -RNRCLPMNFRAEDLASGILRERVKV----------------------------------GASLA 400

  Fly   455 VVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLR-APAKG 518
            .|....:::               .|.:..|.|......||:|||:.|.:.||:|...: .|.:|
Human   401 DVDPMNIDK---------------SVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRG 450

  Fly   519 LLLFGPPGNGKTLLARAVATECS-----ATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSI 578
            .|.:||||.||||:|||:|.|||     ..|.....|...||:||:.|:.:|.||..|..|:|||
Human   451 CLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSI 515

  Fly   579 IFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALR--R 641
            ||.||:|.|...|||.:.:....:.:..|...|||....:   |||:.||||...:|.|..|  |
Human   516 IFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDNRGE---IVVIGATNRLDSIDPALRRPGR 577

  Fly   642 FTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIR-- 704
            |.:....:|||::.|:.:|....:.....|....|..||:...||.|:|:.||..:|||..:|
Human   578 FDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIALRRR 642

  Fly   705 --ELNVEQVKC-LDISAMRAITEQDFHSSLKRI 734
              ::.....|. ||:|:: .::.|||:.:::.|
Human   643 YPQIYASSHKLQLDVSSI-VLSAQDFYHAMQNI 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	16/88 (18%)
		P-loop_NTPase	482..>538	CDD:304359	25/56 (45%)
		AAA	515..652	CDD:214640	59/143 (41%)
		AAA	519..650	CDD:278434	56/137 (41%)
		Vps4_C	<722..754	CDD:286426	4/13 (31%)
ATAD2B	XP_011531220.1	AAA	447..588	CDD:214640	59/143 (41%)
		AAA	452..586	CDD:278434	56/136 (41%)
		COG5076	866..>1100	CDD:227408
		Bromo_AAA	974..1085	CDD:99957
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810