Protein Alignment spas and PEX1

DIOPT Version :10

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_000457.1
• Gene: PEX1 / 5189
• HGNCID: 8850
• Length: 1283
• Species: Homo sapiens
• Alignment Length: 843
• Identity: 185/843 - (21%)
• Similarity: 276/843 - (32%)
• Gaps: 321/843 - (38%)

  Fly   126 FNVLRSLIYQLFCIFRY-------LYGASTKVIYRPHRRDCNIEI-------------------- 163
            |..::|.:..|..|||.       :|.||...::..|   |.|.:
Human   273 FKNMQSKVVPLDNIFRVCKSQPPSIYNASATSVFHKH---CAIHVFPWDQEYFDVEPSFTVTYGK 334

  Fly   164 VVQNSSKEQQQSLNHPSELNREGDGQEQQLSNQPQRFRPIQPLEMAANRPGGGYSPGPGDPLLAK 228
            :|:..|.:||||....:.|:.|   :|:|:|         :||:
Human   335 LVKLLSPKQQQSKTKQNVLSPE---KEKQMS---------EPLD--------------------- 366

  Fly   229 QKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIA----VDCWSGRGDVW---DR 286
                        .|.::.|...|..|...:::...|::||.:.|.    |:... .|.||   |.
Human   367 ------------QKKIRSDHNEEDEKACVLQVVWNGLEELNNAIKYTKNVEVLH-LGKVWIPDDL 418

  Fly   287 AQRLHDKMQ------------------------------------------------TNLSMARD 303
            .:||:.:|.                                                |.|.:...
Human   419 RKRLNIEMHAVVRITPVEVTPKIPRSLKLQPRENLPKDISEEDIKTVFYSWLQQSTTTMLPLVIS 483

  Fly   304 RLHFLALREQD-LQMQRLSL-----KEKQKEEAQSKP---QKTR-----EPMLAGMTNEPMK--- 351
            ...|:.|..:| |:...||:     |||.|......|   |||.     :||:....:|.:.
Human   484 EEEFIKLETKDGLKEFSLSIVHSWEKEKDKNIFLLSPNLLQKTTIQVLLDPMVKEENSEEIDFIL 548

  Fly   352 --LRVRSSG----YGPKATTSAQPTASGR-------KLTIGSKRPVNLAVANK---SQTLPR--- 397
              |::.|.|    .|..:......:..||       .|..|.:....|....|   ..||.:
Human   549 PFLKLSSLGGVNSLGVSSLEHITHSLLGRPLSRQLMSLVAGLRNGALLLTGGKGSGKSTLAKAIC 613

  Fly   398 -------------------------NLGSKTSVG---AVQRQPA-------KTAATPPAVRRQFS 427
                                     |:.....|.   ||..||:       ...|..|||.....
Human   614 KEAFDKLDAHVERVDCKALRGKRLENIQKTLEVAFSEAVWMQPSVVLLDDLDLIAGLPAVPEHEH 678

  Fly   428 SGRNTPPQRSRTPINN----------------NGPSGSGASTPVVSVKGV--------------E 462
            |......||....:|:                ...|.......:||.:||              |
Human   679 SPDAVQSQRLAHALNDMIKEFISMGSLVALIATSQSQQSLHPLLVSAQGVHIFQCVQHIQPPNQE 743

  Fly   463 Q------------------KLVQLILDEIVE--GG------------------------------ 477
            |                  |...|.|..:.:  ||
Human   744 QRCEILCNVIKNKLDCDINKFTDLDLQHVAKETGGFVARDFTVLVDRAIHSRLSRQSISTREKLV 808

  Fly   478 --------------------------AKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPA 516
                                      ..:.|..|.|....:|.|.:.:.||:..||||..|  |.
Human   809 LTTLDFQKALRGFLPASLRSVNLHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANL--PI 871

  Fly   517 K---GLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSI 578
            :   |:||:||||.||||||..:|.|....|:::....|.|||:|..|:.||.:|..|:..:|.|
Human   872 RQRTGILLYGPPGTGKTLLAGVIARESRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCI 936

  Fly   579 IFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALR--R 641
            :|.||.:|:...|.......:.|:..:.|.:.||:.|.   ..:.|||||:||..:|.|.||  |
Human   937 LFFDEFESIAPRRGHDNTGVTDRVVNQLLTQLDGVEGL---QGVYVLAATSRPDLIDPALLRPGR 998

  Fly   642 FTKRVYVSLPDEQTRELLLNRLLQKQGSPL-DTEALRRLAKITDGYSGSDLTALAKDAALEPI 703
            ..|.||...||:.:|..:||.|  ....|| |...|:.:|.:||.::|:||.||..:|.||.:
Human   999 LDKCVYCPPPDQVSRLEILNVL--SDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEAL 1059

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	18/132 (14%)
		RecA-like_spastin	484..648	CDD:410932	64/168 (38%)
		AAA_lid_3	676..727	CDD:465537	12/28 (43%)
		Vps4_C	<722..754	CDD:462762
PEX1	NP_000457.1	PEX-2N	17..98	CDD:462730
		PEX-1N	104..179	CDD:462729
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	346..367		8/65 (12%)
		CDC48	<595..1065	CDD:273521	117/472 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1260..1283