DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spas and AT5G52882

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001078747.1	Gene:	AT5G52882 / 5008305	AraportID:	AT5G52882	Length:	829	Species:	Arabidopsis thaliana

Alignment Length:	866	Identity:	225/866 - (25%)
Similarity:	366/866 - (42%)	Gaps:	182/866 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 KSPIKSSSGAG-SSGGGLGGRQSTHRSSSASNVAAVVAGGSSAAG-GGSSSNRRSPGSSPDGDDD 81
            ||.:.|:.|.| ..|.||...||..|.::.|        ||...| .|....:.......||.:.
plant     4 KSVLLSALGVGVGLGIGLASGQSLGRWANGS--------GSVEDGLTGEQIEQELIRQIVDGRES 60

  Fly    82 TTTTDDLTPTTCSPRS-------GHHHSYGGYSSSVHKQNL------YVVSFPIIFLFNVLRSLI 133
            |.|.::. |...|.|:       .:.| ...|..|.|.:||      .::|.|..|...:|...:
plant    61 TVTFEEF-PYFLSKRTRELLTSVAYVH-LKEYDISKHTRNLAPASKAILLSGPAEFYQQMLAKAL 123

  Fly   134 YQLF-------------CIFRYLYGASTKVIYRPHRRDCN------IEIVVQNSSKEQQQSLNHP 179
            ...|             ...:..||.:.:..:  |:|..:      :..::.:.|...|:.:...
plant   124 SHYFESKLLLLDITDFSIKIQSKYGCTKREPF--HKRSISELTLDKVSSLMGSFSMLSQREVEPR 186

  Fly   180 SELNREGDGQE-QQLSNQPQRFRPIQPLEMAANRPGGGYSPGPGDPLLAKQKHHHRRAFE---YI 240
            ..|.|...|.: :..|.:.....|......:|.......|......:.|.:|......|:   ::
plant   187 GTLRRHTSGNDLKSRSTESSNRLPRHKRNASAASDISSISSRSSSSVSASRKRTTNLCFDEKLFL 251

  Fly   241 SKALKI---------------DEENEGHKELAIELYRKGIKELEDGIAV----------DCWSGR 280
            ....|:               |.|.....|...:|:::.:.:|...:.:          ||
plant   252 QSLYKVLSSVSETTPLIIYLRDVEKLLESERFYKLFQRLLNKLSGPVLILGSRVLEPEDDC---- 312

  Fly   281 GDVWDRAQRLHDKMQTNLSMARDRLHFLALREQDLQMQRLSLKEKQKEEA-----QSKPQKTREP 340
                         .:.:.|::....:.:.:|..:.:.|.:|.|.:.:::.     |.......|.
plant   313 -------------QEVDESISALFPYNIEIRPPEDESQLVSWKSRLEDDMKMIQFQDNKNHIAEV 364

  Fly   341 MLAG-----------------MTNEPMKLRVRSSGYGPKATTSAQPTASGRKLTIGSKR-PVNLA 387
            :.|.                 ::|...::.|.:..|  ....:.:|.....||.|.||. ...|:
plant   365 LAANDIQCDDLSSICHADTMCLSNHIEEIVVSAITY--HLIHTKEPEYRNGKLVISSKSLSHGLS 427

  Fly   388 VANK--------SQTLPRNLGSKTSVGAV-QRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINN 443
            :..:        |..|..|..||...|.| .:..:|:.   |..:.:  |..:.|..::..|:..
plant   428 IFQEGGNRSFEDSLKLDTNTDSKRKGGEVCSKSESKSG---PENKNE--SEISLPSNKNDNPLPP 487

  Fly   444 NGPSGSGASTPVVSVKGVEQKLVQLILDEIVEGG-AKVEWTDIAGQDVAKQALQEMVILPSVRPE 507
            ..|.       ||.....|::    |..|::... ..|.:.||...|..|.:|||:|:||..||:
plant   488 KAPE-------VVPDNEFEKR----IRPEVIPANEIGVTFADIGSLDETKDSLQELVMLPLRRPD 541

  Fly   508 LFT-GLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVA 571
            ||. ||..|.:|:|||||||.|||:||:|:|.|..|:|:|:|.:::|||:.|:.||.|||||.:|
plant   542 LFQGGLLKPCRGILLFGPPGTGKTMLAKAIANEAGASFINVSMSTITSKWFGEDEKNVRALFTLA 606

  Fly   572 RHMQPSIIFIDEVDSLLSERSS-SEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELD 635
            ..:.|:|||:|||||:|.:|:. .||||.|::|.||:..:|||...| |:||:||||||||.:||
plant   607 AKVSPTIIFVDEVDSMLGQRTRVGEHEAMRKIKNEFMTHWDGLMTKP-GERILVLAATNRPFDLD 670

  Fly   636 EAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEAL--RRLAKITDGYSGSDLTALAKDA 698
            ||.:|||.:|:.|.||..::||.:|..||.|:    .||.|  ..|.:||:|||||||..|...|
plant   671 EAIIRRFERRIMVGLPSIESREKILRTLLSKE----KTENLDFHELGQITEGYSGSDLKNLCITA 731

  Fly   699 ALEPIRELNVEQVKCLD---------------------------ISAMRAITEQDFHSSLKRIRR 736
            |..|:||| ::|.:..|                           :..:|.:..:|...:..::..
plant   732 AYRPVREL-IQQERLKDQERKKREEAGKGTEESKEEEAEASEERVITLRPLNMEDMRKAKTQVAA 795

  Fly   737 SVAPQ--SLNSYEKWSQDYGD 755
            |.|.:  .:|..::|:..||:
plant   796 SFASEGAGMNELKQWNDLYGE 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	11/105 (10%)
		P-loop_NTPase	482..>538	CDD:304359	31/56 (55%)
		AAA	515..652	CDD:214640	77/137 (56%)
		AAA	519..650	CDD:278434	74/131 (56%)
		Vps4_C	<722..754	CDD:286426	5/33 (15%)
AT5G52882	NP_001078747.1	P-loop_NTPase	515..>575	CDD:304359	32/59 (54%)
		AAA	552..686	CDD:214640	75/134 (56%)
		AAA	554..685	CDD:278434	74/131 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810