DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and Pex1

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001102690.1	Gene:	Pex1 / 500006	RGDID:	1559939	Length:	1283	Species:	Rattus norvegicus

Alignment Length:	228	Identity:	86/228 - (37%)
Similarity:	125/228 - (54%)	Gaps:	11/228 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   482 WTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAK---GLLLFGPPGNGKTLLARAVATECSAT 543
            |..|.|....:|.|.:.:.||:..||||..|  |.:   |:||:||||.||||||..||.|....
  Rat   839 WDKIGGLHEVRQILMDTIQLPAKYPELFANL--PIRQRTGILLYGPPGTGKTLLAGVVARESGMN 901

  Fly   544 FLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLV 608
            |::|....|.|||:|..|:.||.:|..|:..:|.|:|.||.:|:...|.......:.|:..:.|.
  Rat   902 FISIQGPELLSKYIGASEQAVRDVFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDRVVNQLLT 966

  Fly   609 EFDGLPGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYVSLPDEQTRELLLNRLLQKQGSPL 671
            :.||:.|.   ..:.|||||:||..:|.|.||  |..|.||...||:.:|..:|. :|.|.....
  Rat   967 QLDGVEGL---QGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILT-VLSKSLPLA 1027

  Fly   672 DTEALRRLAKITDGYSGSDLTALAKDAALEPIR 704
            |...|:.:|.:|:.::|:||.||..:|.||.::
  Rat  1028 DDVDLQHVASVTESFTGADLKALLYNAQLEALQ 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	27/58 (47%)
		AAA	515..652	CDD:214640	56/141 (40%)
		AAA	519..650	CDD:278434	54/132 (41%)
		Vps4_C	<722..754	CDD:286426
Pex1	NP_001102690.1	PEX-2N	19..98	CDD:286362
		PEX-1N	104..179	CDD:286361
		AAA	591..741	CDD:214640
		AAA	595..724	CDD:278434
		AAA	877..1009	CDD:214640	54/134 (40%)
		AAA	877..1006	CDD:278434	54/131 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900