DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spas and NVL

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	XP_016856867.1	Gene:	NVL / 4931	HGNCID:	8070	Length:	917	Species:	Homo sapiens

Alignment Length:	848	Identity:	193/848 - (22%)
Similarity:	320/848 - (37%)	Gaps:	212/848 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVRTKNQSSSSSASSSSTKSPIKSSSGAGSSGGGLGGRQSTHRSSSASNVAAVVAGGSSAAGGGS 65
            |.:.:..||:...||.:...|:|:.:.....|..:....|..:.|...:::.            .
Human   175 MEQRETTSSTPRISSKTGSIPLKTPAKDSEGGWFIDKTPSVKKDSFFLDLSC------------E 227

  Fly    66 SSNRRSPGSS-PDGDDDTTTTDDLTPTTCSPRSGHHHSYGGYSSSVHKQNLYVVSFPIIFLFNVL 129
            .||.:.|.:. .|..|.:....|:      .|.|...:.|   |...|::|..|
Human   228 KSNPKKPITEIQDSKDSSLLESDM------KRKGKLKNKG---SKRKKEDLQEV----------- 272

  Fly   130 RSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQNSSKEQQQSLNHPSELNREGDGQEQQLS 194
                                        |..||.|:|..:|.:               |.|.|:|
Human   273 ----------------------------DGEIEAVLQKKAKAR---------------GLEFQIS 294

  Fly   195 NQPQRFRPIQPLEMAANR--------------------PGGGY----SPGPGDPLLAKQKHHHRR 235
            |  .:|..:...:|....                    |..|.    .||.|..|||     |..
Human   295 N--VKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLA-----HAI 352

  Fly   236 A-------------FEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRA 287
            |             |::....   |......:||.:.:.:....|:..|:     ||..:
Human   353 AGAECSGMITAHCSFDFSGSN---DPPASASQELDLPILKVAAPEIVSGV-----SGESE----- 404

  Fly   288 QRLHDKMQTNLSMARDRLHFLALREQDLQMQRLSLKEKQKEE---AQ--------SKPQKTREPM 341
            |:|.:..:..:|.|.   ..:.:.|.|....:..:..|..|.   ||        :....|...:
Human   405 QKLRELFEQAVSNAP---CIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVL 466

  Fly   342 LAGMTNEPMKL--RVRSSGYGPKATTSAQPTASGRKLTIGS-----KRPVNLAVANKSQTLPRNL 399
            :.|.||.|..|  .:|.:|...:......|..:.|:..:.:     :.|......:.:...|..:
Human   467 VIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFV 531

  Fly   400 GSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGAST-PVVSVKGVEQ 463
            |:  .:.|:.|:.|..|.....::.|....:|  |:....|  :.|.......| |....:...|
Human   532 GA--DLMALCREAAMCAVNRVLMKLQEQQKKN--PEMEDLP--SKGVQEERLGTEPTSETQDELQ 590

  Fly   464 KLVQLILDE-----------------------IVEGGAK---------VEWTDIAGQDVAKQALQ 496
            :|:.|:.|:                       .|:..||         |.|.||...:..::.|.
Human   591 RLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELT 655

  Fly   497 EMVILPSVRPELF--TGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGD 559
            ..::.|...|:.|  .||..|| |:||.||||.||||||:|||.|....|:::....|.:.|||:
Human   656 MAILAPVRNPDQFKALGLVTPA-GVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGE 719

  Fly   560 GEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVV 624
            .|:.||.:|..|::..|.:||.||||:|...||..|..||.|:..:.|.|.|||...   .::.:
Human   720 SERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEAR---QQVFI 781

  Fly   625 LAATNRPQELDEAALR--RFTKRVYVSLPDEQTRELLLNRLLQKQGS--PLDTEALRRLAKIT-- 683
            :||||||..:|.|.||  |..|.::|.||....| |.:.:.:.|.|:  |||.:.  .|..|.
Human   782 MAATNRPDIIDPAILRPGRLDKTLFVGLPPPADR-LAILKTITKNGTKPPLDADV--NLEAIAGD 843

  Fly   684 ---DGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNS 745
               |.|:|:||:||.::|::..:|:....|....:...:: ::.:.|..:.|::|.|::.:....
Human   844 LRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELK-VSHKHFEEAFKKVRSSISKKDQIM 907

  Fly   746 YEK 748
            ||:
Human   908 YER 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	14/90 (16%)
		P-loop_NTPase	482..>538	CDD:304359	26/57 (46%)
		AAA	515..652	CDD:214640	62/138 (45%)
		AAA	519..650	CDD:278434	58/132 (44%)
		Vps4_C	<722..754	CDD:286426	6/27 (22%)
NVL	XP_016856867.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900