DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and nmd

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001285801.1	Gene:	nmd / 44021	FlyBaseID:	FBgn0005322	Length:	369	Species:	Drosophila melanogaster

Alignment Length:	288	Identity:	113/288 - (39%)
Similarity:	177/288 - (61%)	Gaps:	12/288 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   458 VKGVEQKLVQLILDE--IVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLR---APAK 517
            ::|.|....:|::..  :|.....|.|.||||.|...|.|:|.|:||....:||...:   || |
  Fly    70 LRGQEFSDYELMIASHLVVPADITVSWADIAGLDSVIQELRESVVLPIQHKDLFKHSKLWQAP-K 133

  Fly   518 GLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFID 582
            |:||.||||.||||:|:|.|.|....|:|:..|.||.|:.|:.:||..|:|::|..::|.|||||
  Fly   134 GVLLHGPPGCGKTLIAKATAKEAGMRFINLDVAILTDKWYGESQKLTSAVFSLASRIEPCIIFID 198

  Fly   583 EVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVY 647
            |:||.|..|:.::|||:..:||:|::.:|||..|.: ..::|:.||||||:||:|.:||...:.:
  Fly   199 EIDSFLRSRNMNDHEATAMMKTQFMMLWDGLSTNAN-STVIVMGATNRPQDLDKAIVRRMPAQFH 262

  Fly   648 VSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQ-- 710
            :.||.|..|:.:|..:||.:....|.: |.||:|:|:|:|||||..:.::|::..:|:|...:
  Fly   263 IGLPSETQRKDILKLILQSEEVSQDVD-LNRLSKLTNGFSGSDLREMCRNASVYRMRQLITSRDP 326

  Fly   711 -VKCLDISAMRAITEQDFHSSLKRIRRS 737
             ...||.:.:| ||..|...|..:|:.|
  Fly   327 SATALDRNNVR-ITMDDLLGSHLKIKES 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	30/58 (52%)
		AAA	515..652	CDD:214640	63/136 (46%)
		AAA	519..650	CDD:278434	59/130 (45%)
		Vps4_C	<722..754	CDD:286426	6/16 (38%)
nmd	NP_001285801.1	AAA	132..266	CDD:214640	62/135 (46%)
nmd	NP_001285801.1	AAA	135..265	CDD:278434	59/130 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467078
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740