DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and Nsf2

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001287318.1	Gene:	Nsf2 / 41694	FlyBaseID:	FBgn0266464	Length:	752	Species:	Drosophila melanogaster

Alignment Length:	429	Identity:	118/429 - (27%)
Similarity:	181/429 - (42%)	Gaps:	108/429 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   362 KATTSAQPTAS------------GRKLTIG--------SKRPVNLAVANKSQTLPRNLGSKTSVG 406
            |.||:.:|..|            |..||:|        .|:.:.|||.......||.:|...
  Fly   110 KKTTTQEPYDSDEMAKEFLMQFAGMPLTVGQTLVFQFKDKKFLGLAVKTLEAVDPRTVGDSL--- 171

  Fly   407 AVQRQPAKTAATPPAVRRQFSSGR---NTPPQRSRTPINNNGPSGSGASTPVVSVKGVEQ-KLV- 466
                  .||        |....||   ||..|..:            |...|::::|..: |:|
  Fly   172 ------PKT--------RNVRFGRILGNTVVQFEK------------AENSVLNLQGRSKGKIVR 210

  Fly   467 QLILDEIVEGGAKVEW----TDIAGQD-----VAKQALQEMVILPSVRPELFTGLRAPAKGLLLF 522
            |.|::.        :|    ..|.|.|     :.::|....|..|.:..:|  |:: ..||:||:
  Fly   211 QSIINP--------DWDFGKMGIGGLDKEFNAIFRRAFASRVFPPELVEQL--GIK-HVKGILLY 264

  Fly   523 GPPGNGKTLLARAVATECSATFLNI-SAASLTSKYVGDGEKLVRALFAVA----RHMQPS----I 578
            ||||.||||:||.:.|..:|....| :...:..||||:.|..:|.|||.|    :.:.|:    |
  Fly   265 GPPGTGKTLMARQIGTMLNAREPKIVNGPQILDKYVGESEANIRRLFAEAEEEEKRLGPNSGLHI 329

  Fly   579 IFIDEVDSLLSER-----SSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAA 638
            |..||:|::...|     :|..|:.   :..:.|.:.||:   ...:.|:|:..|||...:|||.
  Fly   330 IIFDEIDAICKARGSVAGNSGVHDT---VVNQLLAKIDGV---EQLNNILVIGMTNRRDMIDEAL 388

  Fly   639 LR--RFTKRVYVSLPDEQTRELLLN------RLLQKQGSPLDTEALRRLAKITDGYSGSDLTALA 695
            ||  |...::.:|||:||.|..:||      |...|..|.:|.   ..:|..|..:||::|..|.
  Fly   389 LRPGRLEVQMEISLPNEQGRVQILNIHTKRMRDFNKIASDVDN---NEIAAKTKNFSGAELEGLV 450

  Fly   696 KDAALEPIRELNVEQVKC-LDISAMR--AITEQDFHSSL 731
            :.|....:..|.....|. :|..||.  .:|..||..:|
  Fly   451 RAAQSTAMNRLIKADSKVHVDPEAMEKLRVTRADFLHAL 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	23/64 (36%)
		AAA	515..652	CDD:214640	52/152 (34%)
		AAA	519..650	CDD:278434	48/146 (33%)
		Vps4_C	<722..754	CDD:286426	4/10 (40%)
Nsf2	NP_001287318.1	CDC48_N	9..89	CDD:215012
		CDC48_2	117..>170	CDD:215011	13/52 (25%)
		AAA	259..404	CDD:214640	52/150 (35%)
		AAA	261..402	CDD:278434	48/146 (33%)
		AAA	543..674	CDD:214640
		P-loop_NTPase	544..>613	CDD:304359
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900