Protein Alignment spas and CG16789

DIOPT Version :10

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_649910.3
• Gene: CG16789 / 41154
• FlyBaseID: FBgn0037712
• Length: 831
• Species: Drosophila melanogaster
• Alignment Length: 553
• Identity: 120/553 - (21%)
• Similarity: 218/553 - (39%)
• Gaps: 116/553 - (20%)

  Fly   226 LAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRL 290
            |.|.:|:.:|   |.::|....|..|....|..|:..|....:::.||.:..:...|.:|:..:|
  Fly   273 LEKLQHNEKR---YQAQAFYGKEFEERQNALKEEIRAKHGASMKEDIADEIRAWVKDCYDKTGKL 334

  Fly   291 HD------------------KMQTNLSMARDRLHFLALREQDLQMQR---LSLKEKQKEEAQSKP 334
            .|                  :.:.:.|.||........:::.....|   |::.|.|.||...:|
  Fly   335 PDFPSEDQGGSLHIFSRPGTESEHSRSSARSSKESRKTKDKSKSPARSGDLNVNENQDEEVSFQP 399

  Fly   335 ---------------------QKTREPMLAGMTNEPMKLRVRSSGYGPKATTSAQPTASGRKLTI 378
                                 .|....:|:....|.|   :.|..|              :::.:
  Fly   400 APSVCLPDIRAEIDLFNDTWRDKDETGVLSQAAYEDM---IYSDKY--------------QEVEL 447

  Fly   379 GSKRPVNLAVANKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSR--TPI 441
            ..:|.|:..:..:.:.|...:|.|     |::...||       ||   ||:.:..::.:  ||.
  Fly   448 EFRRAVDDVMRQEIELLQTAVGKK-----VKKSSKKT-------RR---SGKKSKKKKEKDLTPD 497

  Fly   442 NNNGPSGSGASTPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRP 506
            ...........|..:..|..|.:|.|.:.|:.:.  |:: .|:.:..|: :|.|.|..||| :..
  Fly   498 RTTESLYEELVTNGIIRKYPELRLKQFLGDKALT--ARI-GTNPSPGDI-RQILTEYCILP-LGS 557

  Fly   507 ELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGE--KLVRALFA 569
            :.........:.:||.||.|:||..|..|:.||..|...:::.|::..||.|...  .|:..:..
  Fly   558 DAIHNCTPLIRSILLAGPKGSGKKALLHAICTEVGAVLFDLTPANIVGKYPGKSGLIMLIHLVLK 622

  Fly   570 VARHMQPSIIFIDEVD-SLLSERSSSEHEASRRLKTEFLVEFDGLPG-----NPDGDRIVVLAAT 628
            |:|.:||::||:.:.: ..:.:...::....:|||.:       ||.     .|: ||:|.:..:
  Fly   623 VSRLLQPAVIFMGDAERPFMKKIPKTDRTDPKRLKKD-------LPKLIKNIAPE-DRVVFIGTS 679

  Fly   629 NRPQELDEAALRR-FTKRVYVSLPDEQTRELLLNRLLQKQG---SPLDTEALRRLAKITDGYSGS 689
            |.|.|.|:..|:. :.:.:|:..||..........||....   |.|||.|   :|||:|||:..
  Fly   680 NLPWEADQKLLQSVYNRFIYIPRPDYGAMSHAWKTLLHDYSGGISNLDTSA---MAKISDGYTIG 741

  Fly   690 DLTALAKDA---------ALEPIRELNVEQVKC 713
            .:.|..|:.         ..:|:....:..|.|
  Fly   742 SIDACLKEVMTCKRKLQLRTQPLTNAELINVLC 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	18/95 (19%)
		RecA-like_spastin	484..648	CDD:410932	44/172 (26%)
		AAA_lid_3	676..727	CDD:465537	11/47 (23%)
		Vps4_C	<722..754	CDD:462762
CG16789	NP_649910.3	DUF5401	<131..>307	CDD:375164	10/36 (28%)
		SpoVK	443..773	CDD:440232	85/360 (24%)
		P-loop containing Nucleoside Triphosphate Hydrolases	542..700	CDD:476819	44/167 (26%)