DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and pch2

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001287235.1	Gene:	pch2 / 41013	FlyBaseID:	FBgn0051453	Length:	421	Species:	Drosophila melanogaster

Alignment Length:	425	Identity:	102/425 - (24%)
Similarity:	161/425 - (37%)	Gaps:	117/425 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   387 AVANKSQT-----------LPRNLGSKTSVGAVQR---------------QPAKTAATPPAVRRQ 425
            |:.|..:|           ||||:.....:.|.|.               ||.|.|.|  ..|..
  Fly    25 AIRNNVETALKAYFQTARKLPRNVSFLPDLTAEQTEHVHSVLLERDNGGVQPLKVAET--KFRFH 87

  Fly   426 FSSGRNTPPQRSRTPI--NNNGPSG-------SGASTPVVSVKGVEQKLVQLILDEIVEGGAKVE 481
            |.:   |.|:..:..:  ...|..|       |.|..|.....|:.:.|       |.|.|.|
  Fly    88 FYA---TRPEEGQLGLFSGEEGSDGIDSIVAASHALLPAAQFVGLWENL-------IYETGLK-- 140

  Fly   482 WTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECS----- 541
                  :.:.|.||..::.   ....:.|.:.|..:.:||.||||.|||.|.:|:|.:.|
  Fly   141 ------EKLLKFALSALMF---SEHRVDTNVIACNRLILLHGPPGTGKTSLCKALAQKLSIRTQG 196

  Fly   542 ----ATFLNISAASLTSKYVGDGEKLVRALFAVARHM--QPS---IIFIDEVDSLL---SERSSS 594
                ...:.|::.||.||:..:..|||..||.....:  .|:   .:.||||:||.   |..||:
  Fly   197 SYAYTHLVEINSHSLFSKWFSESGKLVAQLFNKIAELVSDPNNLVCVLIDEVESLAYARSAMSSN 261

  Fly   595 EHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLP-------- 651
            |...:.|:....|.:.|.|...|:   :::||.:|..|.:|.|.:.|...|:::..|
  Fly   262 EPRDAMRVVNAVLTQLDSLKTCPN---VLILATSNLAQSIDLAFVDRADIRLFIGYPGISAIREI 323

  Fly   652 --------------------DEQTRELLLNRLLQKQGSPLDTEALRRLAKITDG-YSGSDLTALA 695
                                .|...|.||.:|.::... |....||:|..:... |:.|.|..|.
  Fly   324 YKGMLAELMSAGVLQREVLESEDAEEGLLTQLAERSVG-LSGRTLRKLPLLAHAQYTSSTLFELD 387

  Fly   696 K--------DAALEPIRELNVEQVKCLDISAMRAI 722
            :        ||.||.: |.::.:.:.|.:.:|..:
  Fly   388 QKISLSDFLDAMLEAL-EQHLGEQRLLKLESMEQL 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	16/55 (29%)
		AAA	515..652	CDD:214640	48/181 (27%)
		AAA	519..650	CDD:278434	47/147 (32%)
		Vps4_C	<722..754	CDD:286426	0/1 (0%)
pch2	NP_001287235.1	AAA	166..315	CDD:214640	47/151 (31%)
pch2	NP_001287235.1	AAA	169..314	CDD:278434	47/147 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900