DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spas and nvl

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_998649.1	Gene:	nvl / 406805	ZFINID:	ZDB-GENE-040426-2871	Length:	796	Species:	Danio rerio

Alignment Length:	890	Identity:	202/890 - (22%)
Similarity:	324/890 - (36%)	Gaps:	264/890 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VRTKN-QSSSSSASSSSTKSPIKSSSGAGSSGGGLGGRQSTHRSSSASNVAAVVAGGSSAAGGGS 65
            ::|:| |....||.:|..:...:..         .|.|..|........|.|::...|.:.....
Zfish    21 LKTRNDQYVDVSAMASELQQQFRIE---------YGRRNRTAFRIQVEKVFALICSESDSEFSAL 76

  Fly    66 SSN------RRSPGSSPDGD------DDTTTTDDLTPTTCSPRSGHHHSYGGYSSSVHKQNLYVV 118
            .:.      ||||   .|||      ..|.:.||:..        |.|:
Zfish    77 ENKHLAKRARRSP---EDGDGSHVTASSTDSEDDIPE--------HEHT---------------- 114

  Fly   119 SFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQNSSKEQQQSLNHPSELN 183
                    |.:.|.:..|     |..||:.                 .:||...|:||:....::
Zfish   115 --------NHMNSSLTSL-----YQRGAAN-----------------ASSSSTIQRSLSDDWIID 149

  Fly   184 REGD-GQE-------QQLSNQPQRFRPIQPLEMAANRPGGGYSPGPGDPLLAKQKHHHRRAFEYI 240
            :.|| |||       ::.|:.....|....||.              :....|||.
Zfish   150 KTGDRGQESILIDLCEEESSSTTNQRDSSRLEK--------------EKKSVKQKR--------- 191

  Fly   241 SKALKIDEENEGHKELAIELYRKGIKELE---DGIAVDCWSGRGDVWDRAQRL-----HDKMQTN 297
            .|..|::|::|  ....:...:..:|..|   ..:..:.:.|..:..:...:|     |.::...
Zfish   192 QKKNKLEEDSE--TSAGVPAKKSKVKGFELQFSSVKFEDFGGSDETLEEVCKLLIHMRHPEVYQR 254

  Fly   298 LSMARDR---LH--------FLA---LREQDLQMQRLSLKEKQKEEAQSKPQKTREPMLAGMTNE 348
            |.:...|   ||        .||   ..|..|.:.::|..|.....:....||.||.....:::.
Zfish   255 LGVVPPRGFLLHGPPGCGKTLLAQAVAGETALPLLKISAPELVSGVSGESEQKLRELFEQAISSA 319

  Fly   349 PMKLRVRSSGYGPKATTSAQPTASGRKLTIGSKRPVNLAVANKSQTLPRNLGSKTS------VGA 407
            |..|.:...    .|.|..:.|||         :.:...:..:..|...:|.|...      :||
Zfish   320 PCILFIDEI----DAITPKRETAS---------KDMERRIVAQLLTCMDDLNSMLEPAQVLVIGA 371

  Fly   408 VQRQPAKTAATPPAVRRQFSSGR-------NTPPQRSRTPINNN-------------------GP 446
            ..|..    :..||:||   :||       ..|.:.:|..|...                   .|
Zfish   372 TNRPD----SLDPALRR---AGRFDREICLGIPDEGARMKILKTLCRKIRLPDDFDFRHLARLTP 429

  Fly   447 SGSGAS--------------------------TPVVSVKGVEQKL---VQLILDEI--------- 473
            ...||.                          ||.:::..:...|   |.|..|::
Zfish   430 GYVGADLMALCREAAMNAVNRILLEPTTEDQITPTLALARLLDLLKSSVSLSEDQLAALCVLMSD 494

  Fly   474 -------VEGGAK---------VEWTDIAGQDVAKQALQEMVILPSVRPELF--TGLRAPAKGLL 520
                   |:..||         |.|.|:......::.|...::.|...||.|  .||.||| |||
Zfish   495 FSSSLVRVQPSAKREGFATVPDVTWADVGALQDVREELHMAIMAPIQNPEQFKALGLSAPA-GLL 558

  Fly   521 LFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVD 585
            |.||||.||||||:|||......|:::....|.:.|||:.|:.||.:|...|:..|.:||.||:|
Zfish   559 LAGPPGCGKTLLAKAVANASGLNFISVKGPELLNMYVGESERAVRQVFQRGRNSAPCVIFFDEID 623

  Fly   586 SLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYV 648
            :|...||..|..||.|:..:.|.|.||:...   .::.::||||||..:|.|.||  |..|.:||
Zfish   624 ALCPRRSEHESGASVRVVNQLLTEMDGMENR---RQVFIMAATNRPDIIDPAVLRPGRLDKTLYV 685

  Fly   649 SLPDEQTRELLLNRLLQKQGSP-LDTE-ALRRLAKIT--DGYSGSDLTALAKDAALEPIR----- 704
            .||....|..:||.:.:....| ||:: :|..:|...  :.::|:||:||.::|.:..:|
Zfish   686 GLPPAADRHAILNTITKGGTKPQLDSDVSLEEIAHDARCETFTGADLSALVREACVNALRVHLDP 750

  Fly   705 -ELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEK 748
             :.:.|..|.:.:|.:.      |..:.|::|.||:.:....||:
Zfish   751 AQTHTESAKDIRVSRVH------FEDAFKKVRPSVSKKDQLMYER 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	14/96 (15%)
		P-loop_NTPase	482..>538	CDD:304359	28/57 (49%)
		AAA	515..652	CDD:214640	61/138 (44%)
		AAA	519..650	CDD:278434	57/132 (43%)
		Vps4_C	<722..754	CDD:286426	7/27 (26%)
nvl	NP_998649.1	Nucleolin_bd	2..71	CDD:293330	12/58 (21%)
		RNA_polI_A34	<165..215	CDD:285426	11/74 (15%)
		SpoVK	246..792	CDD:223540	147/574 (26%)
		AAA	264..395	CDD:278434	31/150 (21%)
		P-loop_NTPase	537..>573	CDD:304359	23/36 (64%)
		AAA	557..687	CDD:278434	57/132 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900