Protein Alignment spas and vps4b

DIOPT Version :9

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: XP_009296349.1
• Gene: vps4b / 393880
• ZFINID: ZDB-GENE-040426-1235
• Length: 515
• Species: Danio rerio
• Alignment Length: 572
• Identity: 177/572 - (30%)
• Similarity: 277/572 - (48%)
• Gaps: 122/572 - (21%)

  Fly   240 ISKALKI-----DEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLS 299
            :.||:.|     :|:..||.|.||:.|...:|.....|..:.....|:     |::.:|.:..|.
Zfish     6 LQKAIAIAQKASEEDQAGHFEEAIKSYHHAVKYFLHIIKREPQGKEGN-----QKIREKCKQYLD 65

  Fly   300 MARDRLHFLALREQD---LQMQRLSLKEKQKEEAQSKPQKTREPMLAGMTNEPMKLR-------- 353
            ...:...:|..:|..   .:.:.:.|..|..:|.:::..:           |.::|.
Zfish    66 RVEELQDYLDKKEATSCCYESKAIDLANKASQEDKAENYE-----------EALRLYQHAVQYFL 119

  Fly   354 --VRSSGYGPKATTSAQPTASGRKLTIGSKRPVNLAVANKSQTLPRNLGSKTSVGAVQRQPAKTA 416
              |:....|.||           |.:|.:|....|   ::::.|...|..|      ::.|||
Zfish   120 HVVKYEAQGDKA-----------KQSIRAKCAEYL---DRAEKLKEYLKKK------EKAPAK-- 162

  Fly   417 ATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGASTPVVSVKGVEQKLVQLILD-EIVEGGAKV 480
                            |.:.|::  |:.|....|...|       |:|..|..|. .||.....:
Zfish   163 ----------------PVKESQS--NDKGNESDGEEDP-------EKKKFQNQLSGAIVMEKPNI 202

  Fly   481 EWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATEC-SATF 544
            :|.|:||.:.||:||:|.||||...|.||||.|.|.:|:|||||||.||:.||:|||||. ::||
Zfish   203 KWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTF 267

  Fly   545 LNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVE 609
            .:||::.|.||::|:.||||::||.:||..:||||||||:|||...||.:|.||:||:||||||:
Zfish   268 FSISSSDLVSKWLGESEKLVKSLFTLAREHKPSIIFIDEIDSLCGSRSENESEAARRIKTEFLVQ 332

  Fly   610 FDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTE 674
            ..|: || |.:.|:||.|||.|..||.|..|||.||:|:.||:|..|..:....|....:.|...
Zfish   333 MQGV-GN-DNEGILVLGATNIPWTLDSAIRRRFEKRIYIPLPEEHARSFMFKLNLGTTPNSLTES 395

  Fly   675 ALRRLAKITDGYSGSDLTALAKDAALEPIREL----NVEQVK-----------------C----- 713
            ....|.|.||||||:|::.:.:||.::|:|::    :.:||:                 |
Zfish   396 DFMTLGKKTDGYSGADISIIVRDALMQPVRKVQSATHFKQVRGPSRSDPNVIVDDLLTPCSPGDP 460

  Fly   714 -------LDISAMR----AITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDYG 754
                   :::...:    .::..|...||...:.:|..|.|...:|:::|:|
Zfish   461 QAKEMTWMEVPGEKLLEPIVSMSDMLRSLSNTKPTVNEQDLEKLKKFTEDFG 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	16/72 (22%)
		P-loop_NTPase	482..>538	CDD:304359	34/55 (62%)
		AAA	515..652	CDD:214640	79/137 (58%)
		AAA	519..650	CDD:278434	76/131 (58%)
		Vps4_C	<722..754	CDD:286426	8/31 (26%)
vps4b	XP_009296349.1	MIT	5..79	CDD:294211	17/77 (22%)
		TPR	<8..>118	CDD:223533	23/125 (18%)
		MIT	86..146	CDD:294211	13/84 (15%)
		P-loop_NTPase	206..>260	CDD:304359	33/53 (62%)
		AAA	237..373	CDD:214640	79/137 (58%)
		AAA	241..371	CDD:278434	76/131 (58%)
		Vps4_C	452..512	CDD:286426	9/59 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910