DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and trip13

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_956876.1	Gene:	trip13 / 393554	ZFINID:	ZDB-GENE-040426-1488	Length:	424	Species:	Danio rerio

Alignment Length:	301	Identity:	72/301 - (23%)
Similarity:	128/301 - (42%)	Gaps:	79/301 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   441 INNNGPSG---------SGAS---TPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQ 493
            :|::.||.         |.|:   .|.|...||.:.|       |.|.|.|.:
Zfish    95 LNDDSPSTLNLEEEEELSAANLWLLPAVEFHGVWESL-------IYEEGIKTQ------------ 140

  Fly   494 ALQEMVILPSVRPELF-------TGLRAPAKGLLLFGPPGNGKTLLARAVATECS---------A 542
                  :|..|...:|       :.|.|..:.:||.||||.|||.|.:.:|.:.|         :
Zfish   141 ------LLDYVSTTIFFSDKNVDSNLIAWNRVVLLHGPPGTGKTSLCKGLAQKLSIRLSDRYAHS 199

  Fly   543 TFLNISAASLTSKYVGDGEKLVRALFAVARHM---QPSIIF--IDEVDSLLSERSS----SEHEA 598
            .|:.|::.||.||:..:..|||..:|...:.:   :.:::|  ||||:||.:.||:    :|...
Zfish   200 QFVEINSHSLFSKWFSESGKLVTKMFQKIQELIDDKDALVFVLIDEVESLTAARSAAQAGTEPSD 264

  Fly   599 SRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQT-------- 655
            :.|:....|.:.|.:..:|:   :|:|..:|..:::|.|.:.|...:.|:..|..:.
Zfish   265 AIRVVNSVLTQLDQIKRHPN---VVILTTSNVTEKIDLAFVDRADIKQYIGPPSAKAIFNIYLSS 326

  Fly   656 -RELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALA 695
             .||:..:::..:...:..|.|.     |..:..||:|.|:
Zfish   327 LEELMKRQIIYPRQQLVSLEELE-----TMNFMESDVTRLS 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	15/62 (24%)
		AAA	515..652	CDD:214640	43/154 (28%)
		AAA	519..650	CDD:278434	43/148 (29%)
		Vps4_C	<722..754	CDD:286426
trip13	NP_956876.1	AAA	164..314	CDD:214640	43/152 (28%)
trip13	NP_956876.1	AAA	167..312	CDD:278434	43/147 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900