DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and IQCA1L

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001291348.1	Gene:	IQCA1L / 392843	HGNCID:	22831	Length:	818	Species:	Homo sapiens

Alignment Length:	466	Identity:	106/466 - (22%)
Similarity:	200/466 - (42%)	Gaps:	77/466 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   312 EQDLQMQRLSLKEKQKEEAQSKPQKTREPMLAGMTNEPMKLRVRSSGYGPKATTSAQPTASGRKL 376
            |.::|||....||::|.:.:.|.:|.::   .|...:..|..|       .|.....|:.....:
Human   340 ELEMQMQENRKKEQEKSKEKGKDEKEKK---KGKEEKAKKGEV-------DAVLQVLPSKCIPMI 394

  Fly   377 TIGSKRPVNLAVANKSQTL--PRNLGSKT---------------SVGAVQRQPAK--TAATPPAV 422
            ..|.:..:| ...|:.:::  .:|..|:|               .|..:.||..:  ..|.....
Human   395 CAGHEEYLN-TWKNRCESIHPSQNYDSETLREEKRKEVELEIRIQVDELMRQELRKLRLAVDKEE 458

  Fly   423 RRQFSSGRNTPPQRSRTPINNNGPSGSGASTPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAG 487
            .|...:.:.||.::          :|......:.|.:.||....:|::..::.....|...|..|
Human   459 ERPLRAPKKTPGKK----------TGKKKEKDLTSDRSVESLYEELVISGLLRKSESVALKDYIG 513

  Fly   488 QDV---AKQALQEMVILPSV-----RPELFTGLR---------AP-AKGLLLFGPPGNGKTLLAR 534
            ..:   :..:|.:.:.:||:     ...|:..||         || .:.:||.||.|.||.:|.:
Human   514 DFLYLGSTLSLVKKLPMPSLFDIRQNVALYAVLRLGSPDIHIMAPLIRSILLVGPSGMGKKMLVK 578

  Fly   535 AVATECSATFLNISAASLTSKYVG--DGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHE 597
            ||.||..|...::|..:|..||.|  ..:.:|..:|.|||.:|||:|:|...:....:::..|.:
Human   579 AVCTETGANLFDLSPENLLGKYPGRNGAQMMVHIVFKVARLLQPSVIWIGNAEKNFYKKTPKEDK 643

  Fly   598 A--SRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRV-YVSLPDEQTRELL 659
            .  .:|:|.:.......|   ..|||::::..|:|||..:...|.|..:|: ::..||..:|.:|
Human   644 EMDPKRIKKDLTKALRLL---TPGDRVMLIGTTSRPQLAEMRGLCRVYERILFMPRPDYASRYVL 705

  Fly   660 LNRLLQKQG-SPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAIT 723
            ..|:::.:| .|.....:..|||::|||:...:        |:.|:.:..|: :.|.:| .|.:.
Human   706 WKRMIEARGIQPTQHLDISALAKVSDGYTPGHI--------LQAIQSVLSER-RFLQLS-KRPLV 760

  Fly   724 EQDFHSSLKRI 734
            ..:|...|.::
Human   761 ASEFLGQLVKL 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	20/73 (27%)
		AAA	515..652	CDD:214640	43/142 (30%)
		AAA	519..650	CDD:278434	42/135 (31%)
		Vps4_C	<722..754	CDD:286426	2/13 (15%)
IQCA1L	NP_001291348.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..377		9/35 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	458..482		4/33 (12%)
		SpoVK	<561..734	CDD:223540	54/175 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	795..818
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900