DRSC/TRiP Functional Genomics Resources

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Protein Alignment spas and Spast

DIOPT Version :9

Sequence 1:NP_651206.3 Gene:spas / 42846 FlyBaseID:FBgn0039141 Length:758 Species:Drosophila melanogaster
Sequence 2:XP_008762708.1 Gene:Spast / 362700 RGDID:1308494 Length:614 Species:Rattus norvegicus


Alignment Length:728 Identity:327/728 - (44%)
Similarity:411/728 - (56%) Gaps:156/728 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 AGGGSSSNRRSPGSSPDGDDDTTTTDDLTPTTCSPRSGHHHSYGGYSSSVHKQNLYVVSFPIIFL 125
            :||.|.:..|.|..:               ...:|.:|...:.|    |.||:|||..|:|::..
  Rat    13 SGGASPAPARPPPPA---------------AVPAPAAGPAPAPG----SPHKRNLYYFSYPLVVG 58

  Fly   126 FNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQNSSKEQQQSLNHPSELNREGDGQE 190
            |.:||.|...|..:|.:|               |                               
  Rat    59 FALLRLLACHLGLLFVWL---------------C------------------------------- 77

  Fly   191 QQLSNQPQRF-RPIQPLEMAANRPGGGY---------SPGPGDPLLAKQKHHHRRAFEYISKALK 245
                   ||| |.:    |||.|..|..         :||||.. ....:..|::||||||.||:
  Rat    78 -------QRFSRAL----MAAKRSSGTAPAPASPSTPAPGPGGE-AESVRVFHKQAFEYISIALR 130

  Fly   246 IDEENE-GHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLA 309
            ||||.: |.||.|:|.|:|||:|||.|||| ..:|:|:.::||:||..||.|||.||:|||..|.
  Rat   131 IDEEEKAGQKEQAVEWYKKGIEELEKGIAV-IVTGQGEQYERARRLQAKMMTNLVMAKDRLQLLE 194

  Fly   310 LREQDLQMQRLSLKEKQKEEAQSKPQKTREPMLAGMTNEPMKLRVRS------SGYGPKATTSAQ 368
            ..:..||.              ||.|       ..:.||...|..|:      ||..||      
  Rat   195 KLQPVLQF--------------SKSQ-------TDVYNESTNLTCRNGHLQSESGAVPK------ 232

  Fly   369 PTASGRKLTIGSKRPVNLAVANKSQTLPRN----LGSKTSVGAVQRQPAKTAATPPAVRRQFSSG 429
                       .|.|:..|    |.:|||:    ....|.:....|.|:.:..:..:..|..|..
  Rat   233 -----------KKDPLTHA----SNSLPRSKTVMKSGSTGLSGHHRAPSCSGLSMVSGARPGSGP 282

  Fly   430 RNTPPQRSRTPINNNGPSGSGASTPVVSV---------KGVEQKLVQLILDEIVEGGAKVEWTDI 485
            ..|..:.:..|...|.|     |||..:|         :.|:..|..||::|||:.|..|::.||
  Rat   283 AATTHKGTSKPNRTNKP-----STPTTAVRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDI 342

  Fly   486 AGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAA 550
            |||::|||||||:|||||:||||||||||||:|||||||||||||:||:|||.|.:|||.|||||
  Rat   343 AGQELAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAA 407

  Fly   551 SLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPG 615
            ||||||||:|||||||||||||.:||||||||||||||.||...||:||||||||||:||||:..
  Rat   408 SLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQS 472

  Fly   616 NPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLA 680
            ..| ||::|:.|||||||||||.||||.||||||||:|:||.|||..||.||||||..:.|.:||
  Rat   473 AGD-DRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLA 536

  Fly   681 KITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNS 745
            ::||||||||||||||||||.|||||..||||.:..|.||.|...||..|||:|:|||:||:|.:
  Rat   537 RMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEA 601

  Fly   746 YEKWSQDYGDITI 758
            |.:|::|:||.|:
  Rat   602 YIRWNKDFGDTTV 614

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
spasNP_651206.3 MIT_spastin 230..308 CDD:239142 45/78 (58%)
P-loop_NTPase 482..>538 CDD:304359 46/55 (84%)
AAA 515..652 CDD:214640 108/136 (79%)
AAA 519..650 CDD:278434 103/130 (79%)
Vps4_C <722..754 CDD:286426 16/31 (52%)
SpastXP_008762708.1 MIT_spastin 114..193 CDD:239142 45/79 (57%)
P-loop_NTPase 339..>395 CDD:304359 46/55 (84%)
AAA 372..508 CDD:214640 108/136 (79%)
AAA 376..506 CDD:278434 103/130 (79%)
Vps4_C <578..610 CDD:286426 16/31 (52%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166340433
Domainoid 1 1.000 202 1.000 Domainoid score I2907
eggNOG 1 0.900 - - E1_COG0464
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H8970
Inparanoid 1 1.050 485 1.000 Inparanoid score I1388
OMA 1 1.010 - - QHG48730
OrthoDB 1 1.010 - - D1176820at2759
OrthoFinder 1 1.000 - - FOG0001088
OrthoInspector 1 1.000 - - oto98075
orthoMCL 1 0.900 - - OOG6_100722
Panther 1 1.100 - - LDO PTHR23074
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X3342
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1514.810

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