DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spas and Spata5

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	XP_008759154.1	Gene:	Spata5 / 361935	RGDID:	1310478	Length:	893	Species:	Rattus norvegicus

Alignment Length:	465	Identity:	146/465 - (31%)
Similarity:	209/465 - (44%)	Gaps:	89/465 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   316 QMQRLSLKEKQKEEAQSKP---------QKTREPMLAGMTNEPMKLRVRSSGYGPKATTSAQPTA 371
            |:.:|.|||.|...:||.|         .|..| :|..:|..|..    .||.|.:..|
  Rat   233 QLSQLDLKEPQSPASQSTPCKPINDRTMNKAGE-VLLDVTQSPRD----GSGLGLEEIT------ 286

  Fly   372 SGRKLTIGSKRPVNLAVANKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQR 436
             |.|.:..|.:..|....::.:.|     ..||.||.
  Rat   287 -GLKCSFDSSKEGNTQPISEEKLL-----KSTSAGAK---------------------------- 317

  Fly   437 SRTPINNNGPSGSGASTPVVSVKGV-----EQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQ 496
                 ||.......:||..::::.:     ||           :...||.:..|.|.:...:|::
  Rat   318 -----NNTDTFYFISSTTRINLRKICTNSKEQ-----------DSQFKVTYDMIGGLNSQLKAIR 366

  Fly   497 EMVILPSVRPELFTGLRAPA-KGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDG 560
            |::.||..:||||.....|| :||||:||||.|||::|||||.|..|....|:...:.||:.|:.
  Rat   367 EIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGET 431

  Fly   561 EKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVL 625
            |..:|.:||.|....||||||||:|:|..:|..::.|..:|:....|...||:.......|::||
  Rat   432 EARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIGSEGSEGRVLVL 496

  Fly   626 AATNRPQELDEAALR---RFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYS 687
            .||||||.|| ||||   ||.|.:.:.:|:.|.|..:|.:||::....|....|.|||....||.
  Rat   497 GATNRPQALD-AALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPHLLTKAELLRLANNAHGYV 560

  Fly   688 GSDLTALAKDAALEPIRELNVEQVKCLD--ISAMRAITEQDFHSSLKRIR----RSVAPQSLNSY 746
            |:||.||..:|.|..:|.:..:|....|  ::.|..||..||...:..||    |.||....|
  Rat   561 GADLKALCNEAGLYALRRVLRKQPNLPDSKVAGMVKITLNDFLQGMNDIRPSAMREVAIDVPN-- 623

  Fly   747 EKWSQDYGDI 756
            ..|| |.|.:
  Rat   624 VSWS-DIGGL 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	27/56 (48%)
		AAA	515..652	CDD:214640	63/140 (45%)
		AAA	519..650	CDD:278434	60/133 (45%)
		Vps4_C	<722..754	CDD:286426	13/35 (37%)
Spata5	XP_008759154.1	CDC48_N	64..132	CDD:304500
		SpoVK	370..882	CDD:223540	107/267 (40%)
		AAA	390..522	CDD:278434	60/132 (45%)
		AAA	664..796	CDD:278434
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810