DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spas and TER94

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster

Alignment Length:	643	Identity:	167/643 - (25%)
Similarity:	271/643 - (42%)	Gaps:	134/643 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 KEQQQSLNHPSELNREGDGQEQQLS----------NQPQRFRPIQPLEMAANRPGGGY----SPG 220
            :|:::|||...  ..:..|..:||:          ..|..|:.|      ..:|..|.    .||
  Fly   214 EEEEESLNAVG--YDDIGGCRKQLAQIKEMVELPLRHPSLFKAI------GVKPPRGILMYGPPG 270

  Fly   221 PGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWD 285
            .|..|:|:...:...||.::....:|..:..|..|..:   ||..:|.|.......:....|.
  Fly   271 TGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNL---RKAFEEAEKNSPAIIFIDEIDA-- 330

  Fly   286 RAQRLHDKMQTNLSMARDRLHFLALREQDLQMQRLSLKEKQKEEAQSKPQKTREPMLAGMTNEPM 350
                        ::..||:.|  ...|:.:..|.|:|.:..|        |:...::...||.|.
  Fly   331 ------------IAPKRDKTH--GEVERRIVSQLLTLMDGMK--------KSSHLIVMAATNRPN 373

  Fly   351 KL--RVRSSGYGPKATTSAQPTASGR--KLTIGSKR-----PVNL--AVANKSQTLPRNLGSKTS 404
            .:  .:|..|...:......|.|:||  .|.|.:|.     .|:|  ..|.....:..:|.|..|
  Fly   374 SIDPALRRFGRFDREIDIGIPDATGRLEVLRIHTKNMKLHDDVDLEQIAAESHGHVGADLASLCS 438

  Fly   405 VGAVQ--------------RQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGASTPV 455
            ..|:|              :..|:..|:.......|           |..:..:.||.
  Fly   439 EAALQQIREKMDLIDLEDDKIDAEVLASLAVTMENF-----------RYAMTKSSPSA------- 485

  Fly   456 VSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFT--GLRAPAKG 518
                          |.|.|.......||||.|.:..|:.|||:|..|...|:.|.  |:: |::|
  Fly   486 --------------LRETVVEVPNTTWTDIGGLESVKKELQELVQYPVEHPDKFLKFGMQ-PSRG 535

  Fly   519 LLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDE 583
            :|.:||||.||||||:|:|.||.|.|:::....|.:.:.|:.|..||.:|..||...|.::|.||
  Fly   536 VLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKARSAAPCVLFFDE 600

  Fly   584 VDSLLSERSSSEHE---ASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALR--RFT 643
            :||:...|..:..:   |:.|:..:.|.|.||:....:   :.::.|||||..:|.|.||  |..
  Fly   601 LDSIAKARGGNVGDAGGAADRVINQILTEMDGMGAKKN---VFIIGATNRPDIIDPAILRPGRLD 662

  Fly   644 KRVYVSLPDEQTRELLLNRLLQKQGSPLDTEA-LRRLAKITDGYSGSDLTALAKDAALEPIRELN 707
            :.:|:.|||:::||.:|...|:|  |||..|. |..:||:|.|:||:|||.:.:.|....||:..
  Fly   663 QLIYIPLPDDKSREAILKANLRK--SPLAKEVDLTYIAKVTQGFSGADLTEICQRACKLAIRQAI 725

  Fly   708 VEQVK-----------CLDI---SAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKWSQ 751
            ..:::           .:|:   ..:..||...|..::|..||||:...:..||.::|
  Fly   726 EAEIRREKERAENQNSAMDMDEDDPVPEITSAHFEEAMKFARRSVSDNDIRKYEMFAQ 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	13/77 (17%)
		P-loop_NTPase	482..>538	CDD:304359	28/57 (49%)
		AAA	515..652	CDD:214640	52/141 (37%)
		AAA	519..650	CDD:278434	49/135 (36%)
		Vps4_C	<722..754	CDD:286426	11/30 (37%)
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	167/643 (26%)
		CDC48_N	47..129	CDD:280513
		CDC48_2	153..213	CDD:215011
		AAA	263..392	CDD:278434	29/155 (19%)
		AAA	536..669	CDD:278434	49/135 (36%)
		Vps4_C	<741..783	CDD:286426	11/41 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810