DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spas and Fign

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001259995.1	Gene:	Fign / 33544	FlyBaseID:	FBgn0031519	Length:	523	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	180/519 - (34%)
Similarity:	286/519 - (55%)	Gaps:	54/519 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   284 WDRAQRLHDKMQTNLSMARDRLHFLALREQDLQMQRL-SLKEKQKEEAQSKPQKTREPMLAGMTN 347
            | |::.|....||..|  .:.:||.||::...::|.. |:::..||..|.|...:|... .|:|:
  Fly     8 W-RSKLLLICQQTRSS--SESIHFAALKDHHARLQACESMEKAMKERCQKKITMSRRTK-RGITH 68

  Fly   348 EPMKLRV-RSSGYGPKA---------TTSAQPTASGRKLTIGSKRPVNLAVANKSQ-TLPRNLGS 401
            ......: .:|.:.|:.         |..|........|.:.|..||..||.::.: ..|.:..:
  Fly    69 AGYLFEMPHNSVFEPECRGFYESCQQTEMASSDLQAPALEVSSTYPVQQAVKSRPEGQFPESRNN 133

  Fly   402 KTSVGAVQRQPAKTA-------------------------------ATPPAV---RRQFSSGRNT 432
            .|.....|:..::::                               |.|..:   |::...|:.|
  Fly   134 STKKIDAQQYSSESSSQSGFGFRTAREQLIMDELKKKNRQATSEVDAVPTGMMNFRKKTLGGKRT 198

  Fly   433 PPQRSRTPI--NNNGPSGSGASTPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQAL 495
            ......:|:  |:|..|...:|.| .::..::.|:|..||.|.:.....|.|.||||.:.||...
  Fly   199 VSSNFVSPVAQNDNSTSSRSSSIP-PALAHLDSKMVDHILGESMHDFKPVAWEDIAGLESAKSTF 262

  Fly   496 QEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDG 560
            .|.:|:|..||:||||:|.|.:|:|||||||.||||:|:::|::..|.|.:|:.:|||||:|||.
  Fly   263 LEAIIMPLRRPDLFTGVRCPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDA 327

  Fly   561 EKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVL 625
            ||||:.|||||...||:||||||||||||:||::|:|::.|||.|||:..||...|.: .|::|:
  Fly   328 EKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTLRLKNEFLIHLDGAASNEE-IRVLVI 391

  Fly   626 AATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSD 690
            .|||||||||||..|||.:|:||.||..:.|:.::.:|:.:....||...:..||::||||||:|
  Fly   392 GATNRPQELDEAVRRRFVRRLYVPLPTREARQKIIEKLIHQVKHNLDVRQVIELAELTDGYSGAD 456

  Fly   691 LTALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDYG 754
            :..|.:.|::.|:|.|..:|::.::...:.|:|..||..:|:.|.:||:.:....:|.|::.||
  Fly   457 VDTLCRYASMAPLRSLTPDQMEVIETHQLPAVTMDDFKQALRVISKSVSSEDCKQFEAWNEIYG 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	7/23 (30%)
		P-loop_NTPase	482..>538	CDD:304359	31/55 (56%)
		AAA	515..652	CDD:214640	82/136 (60%)
		AAA	519..650	CDD:278434	79/130 (61%)
		Vps4_C	<722..754	CDD:286426	9/31 (29%)
Fign	NP_001259995.1	AAA	282..418	CDD:214640	82/136 (60%)
		AAA	286..416	CDD:278434	79/130 (61%)
		Vps4_C	<480..520	CDD:286426	10/39 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467069
Domainoid	1	1.000	40	1.000	Domainoid score	I8560
eggNOG	1	0.900	-	-		E1_COG0464
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1176820at2759
OrthoFinder	1	1.000	-	-		FOG0001088
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100722
Panther	1	1.100	-	-	P	PTHR23074
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.750