DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and Fignl1

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001011913.1	Gene:	Fignl1 / 289777	RGDID:	1307112	Length:	677	Species:	Rattus norvegicus

Alignment Length:	422	Identity:	172/422 - (40%)
Similarity:	259/422 - (61%)	Gaps:	25/422 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   341 MLAGMTNEPMKLRVRSSGYGPKATTSAQPTASGRKLTIGSKRPVNLAVANKSQTLPRNLGS--KT 403
            ||:..|......:...||.....:.....||..:......||      :::||...::...  |.
  Rat   270 MLSNPTLNKAPSKTEDSGQREDNSLPTFKTAKEQLWADQKKR------SHQSQHTSKSFNGAIKK 328

  Fly   404 SVGAVQRQPAKTAATPPAVRRQFSSGR--NTPPQRSRTPINNNGPSGSGASTPV----VSVKGVE 462
            |:||.:.:.......||...:|..|.:  |..|:.||          :|::.|.    ..:|.||
  Rat   329 SLGAGRSRGIFGKFVPPVSNKQDGSEQNGNVKPKSSR----------AGSAEPAHLTDDRLKNVE 383

  Fly   463 QKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGN 527
            .::|:||::||::.|..|.|.||||.:.||..::|:|:.|.:||::|||||.|.||:|||||||.
  Rat   384 PRMVELIMNEIMDHGPPVHWEDIAGVEFAKATIKEIVVWPMMRPDIFTGLRGPPKGILLFGPPGT 448

  Fly   528 GKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERS 592
            ||||:.:.:|::..|||.:|||:|||||:||:|||:|||||||||..||::|||||:|||||:|.
  Rat   449 GKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRG 513

  Fly   593 SSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRE 657
            ..|||:|||:||||||:.||...:.: |||:|:.|||||||:||||.||..||:|:.||:...|:
  Rat   514 DGEHESSRRIKTEFLVQLDGATTSSE-DRILVVGATNRPQEIDEAARRRLVKRLYIPLPEASARK 577

  Fly   658 LLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAI 722
            .::..|:.|:...|..|....:.:.:||:||:|:|.|.::|:|.|||.|:...:..:....:|.|
  Rat   578 QIVVNLMSKEQCCLTDEETELVVQQSDGFSGADMTQLCREASLGPIRSLHTADIATISPDQVRPI 642

  Fly   723 TEQDFHSSLKRIRRSVAPQSLNSYEKWSQDYG 754
            ...||.::.:.:|.||:|:.|..||.|::.:|
  Rat   643 AYIDFENAFRTVRPSVSPKDLELYENWNKTFG 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	31/55 (56%)
		AAA	515..652	CDD:214640	88/136 (65%)
		AAA	519..650	CDD:278434	84/130 (65%)
		Vps4_C	<722..754	CDD:286426	11/31 (35%)
Fignl1	NP_001011913.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..232
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..324		11/59 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..378		10/50 (20%)
		RecA-like_Figl-1	383..568	CDD:410933	111/185 (60%)
		AAA_lid_3	593..>624	CDD:407720	11/30 (37%)
		Vps4_C	<634..674	CDD:401324	12/39 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1176820at2759
OrthoFinder	1	1.000	-	-		FOG0001088
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100722
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720