Protein Alignment spas and Nvl

DIOPT Version :10

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001099450.1
• Gene: Nvl / 289323
• RGDID: 1311270
• Length: 855
• Species: Rattus norvegicus
• Alignment Length: 661
• Identity: 171/661 - (25%)
• Similarity: 275/661 - (41%)
• Gaps: 122/661 - (18%)

  Fly   158 DCNIEIVVQNSSKEQQQSLNHPSELNREGDGQEQQLS---------NQP---QRFRPIQPLEMAA 210
            |..||.::|..:|.:...|...|....:..|.:..|.         ..|   |....:.|..:..
  Rat   238 DGEIEAILQKRAKAKSTELQISSVKFEDVGGNDATLKEVCKMLIHMRHPEVYQHLGVVPPRGVLL 302

  Fly   211 NRPGGGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVD 275
            :.|     ||.|..|||     |..|                 .||.:.:.:....|:..|:
  Rat   303 HGP-----PGCGKTLLA-----HAIA-----------------GELDLPILKVAAPEIVSGV--- 337

  Fly   276 CWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREQDLQMQRLSLKEKQKEE---AQ------ 331
              ||..:     |:|.|.....:|.|.   ..:.:.|.|....:..:..|..|.   ||
  Rat   338 --SGESE-----QKLRDLFDQAVSNAP---CIVFIDEIDAITPKREVASKDMERRIVAQLLTCMD 392

  Fly   332 --SKPQKTREPMLAGMTNEPMKL--RVRSSGYGPKATTSAQPTASGRKLTIGS-----KRPVNLA 387
              :....|...::.|.||.|..|  .:|.:|...:......|..:.|:..:.:     :.|....
  Rat   393 DLNNVAATARVLVVGATNRPDSLDPALRRAGRFDREVCLGIPDEASRERILQTLCRKLRLPETFN 457

  Fly   388 VANKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGAS 452
            .::.:...|..:|:  .:.|:.|:.|..|.....:|||  ..:.|.|:....|.:.......||.
  Rat   458 FSHLAHLTPGFVGA--DLMALCREAAVCAVHRVLMRRQ--EQQRTEPETGGLPSDGEQGRSLGAE 518

  Fly   453 TPVVSVKGVEQKLVQLILDE-----------------------IVEGGAK---------VEWTDI 485
            .| ...:...|:|:.|:.|:                       .|:..||         |.|.|:
  Rat   519 PP-SETQDELQRLLGLLRDQDPISEEQMQGLCLELNDFIVALSEVQPSAKREGFVTVPNVTWADV 582

  Fly   486 AGQDVAKQALQEMVILPSVRPELF--TGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNIS 548
            ...:..::.|...::.|...||.|  .||.||| |:||.||||.||||||:|||.|....|:::.
  Rat   583 GALEDIREELTMAILAPVRNPEQFRALGLVAPA-GVLLAGPPGCGKTLLAKAVANESGLNFISVK 646

  Fly   549 AASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGL 613
            ...|.:.|||:.|:.||.:|..|::..|.:||.||||:|...||..|..||.|:..:.|.|.|||
  Rat   647 GPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGL 711

  Fly   614 PGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYVSLPDEQTRELLLNRLLQKQGS--PLDTE 674
            ...   .::.:|||||||..:|.|.||  |..|.::|.||....|..:| :.:.|.|:  |||.:
  Rat   712 ETR---QQVFILAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRVAIL-KTITKNGTKPPLDED 772

  Fly   675 A-LRRLAK--ITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRR 736
            . |..:|.  ..|.|:|:||:||.::|:|..:|:....|...:. :|...::.:.|..:.::::.
  Rat   773 VDLEAIANDHRCDCYTGADLSALVREASLCALRQEITGQKNGIG-TAELTVSHKHFEEAFRKVKP 836

  Fly   737 SVAPQSLNSYE 747
            |::.:....||
  Rat   837 SISVKDQRMYE 847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	13/77 (17%)
		RecA-like_spastin	484..648	CDD:410932	70/167 (42%)
		AAA_lid_3	676..727	CDD:465537	14/52 (27%)
		Vps4_C	<722..754	CDD:462762	4/26 (15%)
Nvl	NP_001099450.1	Nucleolin_bd	2..71	CDD:465247
		CDC48	<255..855	CDD:273521	166/644 (26%)