DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spas and Nvl

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001099450.1	Gene:	Nvl / 289323	RGDID:	1311270	Length:	855	Species:	Rattus norvegicus

Alignment Length:	661	Identity:	171/661 - (25%)
Similarity:	275/661 - (41%)	Gaps:	122/661 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 DCNIEIVVQNSSKEQQQSLNHPSELNREGDGQEQQLS---------NQP---QRFRPIQPLEMAA 210
            |..||.::|..:|.:...|...|....:..|.:..|.         ..|   |....:.|..:..
  Rat   238 DGEIEAILQKRAKAKSTELQISSVKFEDVGGNDATLKEVCKMLIHMRHPEVYQHLGVVPPRGVLL 302

  Fly   211 NRPGGGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVD 275
            :.|     ||.|..|||     |..|                 .||.:.:.:....|:..|:
  Rat   303 HGP-----PGCGKTLLA-----HAIA-----------------GELDLPILKVAAPEIVSGV--- 337

  Fly   276 CWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREQDLQMQRLSLKEKQKEE---AQ------ 331
              ||..:     |:|.|.....:|.|.   ..:.:.|.|....:..:..|..|.   ||
  Rat   338 --SGESE-----QKLRDLFDQAVSNAP---CIVFIDEIDAITPKREVASKDMERRIVAQLLTCMD 392

  Fly   332 --SKPQKTREPMLAGMTNEPMKL--RVRSSGYGPKATTSAQPTASGRKLTIGS-----KRPVNLA 387
              :....|...::.|.||.|..|  .:|.:|...:......|..:.|:..:.:     :.|....
  Rat   393 DLNNVAATARVLVVGATNRPDSLDPALRRAGRFDREVCLGIPDEASRERILQTLCRKLRLPETFN 457

  Fly   388 VANKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGAS 452
            .::.:...|..:|:  .:.|:.|:.|..|.....:|||  ..:.|.|:....|.:.......||.
  Rat   458 FSHLAHLTPGFVGA--DLMALCREAAVCAVHRVLMRRQ--EQQRTEPETGGLPSDGEQGRSLGAE 518

  Fly   453 TPVVSVKGVEQKLVQLILDE-----------------------IVEGGAK---------VEWTDI 485
            .| ...:...|:|:.|:.|:                       .|:..||         |.|.|:
  Rat   519 PP-SETQDELQRLLGLLRDQDPISEEQMQGLCLELNDFIVALSEVQPSAKREGFVTVPNVTWADV 582

  Fly   486 AGQDVAKQALQEMVILPSVRPELF--TGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNIS 548
            ...:..::.|...::.|...||.|  .||.||| |:||.||||.||||||:|||.|....|:::.
  Rat   583 GALEDIREELTMAILAPVRNPEQFRALGLVAPA-GVLLAGPPGCGKTLLAKAVANESGLNFISVK 646

  Fly   549 AASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGL 613
            ...|.:.|||:.|:.||.:|..|::..|.:||.||||:|...||..|..||.|:..:.|.|.|||
  Rat   647 GPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGL 711

  Fly   614 PGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYVSLPDEQTRELLLNRLLQKQGS--PLDTE 674
            ...   .::.:|||||||..:|.|.||  |..|.::|.||....|..:| :.:.|.|:  |||.:
  Rat   712 ETR---QQVFILAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRVAIL-KTITKNGTKPPLDED 772

  Fly   675 A-LRRLAK--ITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRR 736
            . |..:|.  ..|.|:|:||:||.::|:|..:|:....|...:. :|...::.:.|..:.::::.
  Rat   773 VDLEAIANDHRCDCYTGADLSALVREASLCALRQEITGQKNGIG-TAELTVSHKHFEEAFRKVKP 836

  Fly   737 SVAPQSLNSYE 747
            |::.:....||
  Rat   837 SISVKDQRMYE 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	13/77 (17%)
		P-loop_NTPase	482..>538	CDD:304359	27/57 (47%)
		AAA	515..652	CDD:214640	63/138 (46%)
		AAA	519..650	CDD:278434	59/132 (45%)
		Vps4_C	<722..754	CDD:286426	4/26 (15%)
Nvl	NP_001099450.1	Nucleolin_bd	2..71	CDD:406995
Nvl	NP_001099450.1	CDC48	<255..855	CDD:273521	166/644 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900