DRSC/TRiP Functional Genomics Resources

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Protein Alignment spas and VPS4A

DIOPT Version :9

Sequence 1:NP_651206.3 Gene:spas / 42846 FlyBaseID:FBgn0039141 Length:758 Species:Drosophila melanogaster
Sequence 2:NP_037377.1 Gene:VPS4A / 27183 HGNCID:13488 Length:437 Species:Homo sapiens


Alignment Length:368 Identity:132/368 - (35%)
Similarity:196/368 - (53%) Gaps:60/368 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   435 QRSRTPINNNGPSGSGASTPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMV 499
            :..:.|:..|...|.|:.:........::||.:.::..:|.....:.|.|:||.:.||:||:|.|
Human    79 KHGKKPVKENQSEGKGSDSDSEGDNPEKKKLQEQLMGAVVMEKPNIRWNDVAGLEGAKEALKEAV 143

  Fly   500 ILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATEC-SATFLNISAASLTSKYVGDGEKL 563
            |||...|.||||.|.|.:|:|||||||.||:.||:|||||. ::||.::|::.|.||::|:.|||
Human   144 ILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKL 208

  Fly   564 VRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAAT 628
            |:.||.:||..:||||||||||||...|:.:|.||:||:||||||:..|:..|.||  .:||.||
Human   209 VKNLFELARQHKPSIIFIDEVDSLCGSRNENESEAARRIKTEFLVQMQGVGNNNDG--TLVLGAT 271

  Fly   629 NRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTA 693
            |.|..||.|..|||.||:|:.||:|..|..:....|......|....:..||:.|:||||:|::.
Human   272 NIPWVLDSAIRRRFEKRIYIPLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISI 336

  Fly   694 LAKDAALEPIRELN-----------------------------------------------VEQV 711
            :.:|:.::|:|::.                                               :|.|
Human   337 IVRDSLMQPVRKVQSATHFKKVCGPSRTNPSMMIDDLLTPCSPGDPGAMEMTWMDVPGDKLLEPV 401

  Fly   712 KCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDYG 754
            .|:          .|...||...|.:|....|...:|:|:|:|
Human   402 VCM----------SDMLRSLATTRPTVNADDLLKVKKFSEDFG 434

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
spasNP_651206.3 MIT_spastin 230..308 CDD:239142
P-loop_NTPase 482..>538 CDD:304359 34/55 (62%)
AAA 515..652 CDD:214640 77/137 (56%)
AAA 519..650 CDD:278434 74/131 (56%)
Vps4_C <722..754 CDD:286426 9/31 (29%)
VPS4ANP_037377.1 Interaction with CHMP1B 1..84 0/4 (0%)
PTZ00454 4..348 CDD:240423 118/270 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 75..106 4/26 (15%)
RecA-like_VPS4 121..291 CDD:410929 94/171 (55%)
Vps4_C 374..434 CDD:401324 12/69 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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