DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and SPAC328.04

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_594206.1	Gene:	SPAC328.04 / 2543208	PomBaseID:	SPAC328.04	Length:	741	Species:	Schizosaccharomyces pombe

Alignment Length:	469	Identity:	187/469 - (39%)
Similarity:	262/469 - (55%)	Gaps:	79/469 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 TNEPMKLRVRSSGYGPKATTSAQPTASGRKLTIGSKRPVNLAVANKSQTLPRNLGSKTSVGAVQR 410
            ::.|.|.:.:|  :.|..||.. |:.|.:             ::..|.::.....|..||.:|.:
pombe   288 SSSPFKKKTQS--HLPNRTTEV-PSISKQ-------------LSKSSTSIATVAPSLASVSSVTK 336

  Fly   411 QPAKTAATPPAVRRQFSSGRN-------TPPQRSRT--------PINNNGPSG------------ 448
            .|:.|..:.|  |.|.:|...       |||:.|..        |.:..|.|.
pombe   337 SPSPTPQSAP--RAQSASTETAQDLDFLTPPRLSVNNPFLSDLYPASEQGLSSCEEKDSPVDGDE 399

  Fly   449 ----------------SGASTPVVSVK---------GVEQKLVQLILDEIVEGGAKVEWTDIAGQ 488
                            |.:.:.:.|.|         .::::|.:.||.|||..|.:|.|.||:|.
pombe   400 FFNHTNEEEIIEKQFQSTSISAMTSEKQEQILRECPDIDEELGKSILREIVVSGDEVHWDDISGL 464

  Fly   489 DVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLT 553
            :.||.:|:|.|:.|.:||:||.|||.||:|:|||||||.|||:||||||||..:.|.:|||:|||
pombe   465 EFAKHSLKEAVVYPFLRPDLFQGLREPARGMLLFGPPGTGKTMLARAVATESRSVFFSISASSLT 529

  Fly   554 SKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSS--SEHEASRRLKTEFLVEFDGLP-- 614
            ||::|:.||||||||.:|:.:.|||||:||:|||||.|||  :|||.|||:|||||:::..|.
pombe   530 SKFLGESEKLVRALFTLAKKLSPSIIFVDEIDSLLSARSSDGNEHETSRRIKTEFLIQWSSLARA 594

  Fly   615 ----GNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEA 675
                ...|..|::||||||.|..:|:||.|||.:|.|:.||||.||.|.||.||:.|...|..|.
pombe   595 AASRQTADHPRVLVLAATNLPWCIDDAARRRFVRRTYIPLPDETTRRLHLNNLLKYQKHSLSLED 659

  Fly   676 LRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAP 740
            :..:.|.|:.||||||||||||||:.|:|.|. |.:....:.::|.|...||.:|:|.||.||..
pombe   660 IEAIVKATEYYSGSDLTALAKDAAMGPLRSLG-ESLLFTKMESIRPINLDDFKTSIKVIRPSVNL 723

  Fly   741 QSLNSYEKWSQDYG 754
            |.|..|.:|.:::|
pombe   724 QGLERYSEWDKEFG 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	35/55 (64%)
		AAA	515..652	CDD:214640	85/144 (59%)
		AAA	519..650	CDD:278434	81/138 (59%)
		Vps4_C	<722..754	CDD:286426	13/31 (42%)
SPAC328.04	NP_594206.1	SpoVK	192..734	CDD:223540	186/464 (40%)
		AAA	495..634	CDD:278434	81/138 (59%)
		Vps4_C	<704..737	CDD:286426	13/32 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	159	1.000	Domainoid score	I996
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001088
OrthoInspector	1	1.000	-	-		otm47357
orthoMCL	1	0.900	-	-		OOG6_100722
Panther	1	1.100	-	-	LDO	PTHR23074
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3342
TreeFam	0	0.000	Not matched by this tool.
	8	7.810