DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and pex6

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_593468.1	Gene:	pex6 / 2542437	PomBaseID:	SPAC17A5.01	Length:	948	Species:	Schizosaccharomyces pombe

Alignment Length:	337	Identity:	119/337 - (35%)
Similarity:	180/337 - (53%)	Gaps:	33/337 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   438 RTPINNNGPSGSGASTPVVSVKGVEQKLVQLILDE--IVEGGAKVEWTDIAGQDVAKQALQEMVI 500
            ||..:|:....||   |:::.:.|:..:.::..::  .:....||.|.||.|.:.||..|::.:.
pombe   611 RTGYDNDSIILSG---PIITEQDVDVSINRIRKEKSNTIFTVPKVNWDDIGGLEEAKTVLRDTLQ 672

  Fly   501 LPSVRPELFT-GLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLV 564
            ||...||||: ||: |..|:||:||||.||||||:|||||.|..|::|....|.:.|||:.|..|
pombe   673 LPLQFPELFSQGLK-PRSGVLLYGPPGTGKTLLAKAVATELSLEFVSIKGPELLNMYVGESEANV 736

  Fly   565 RALFAVARHMQPSIIFIDEVDSLLSER--SSSEHEASRRLKTEFLVEFDGLPGNPDGDRIV-VLA 626
            |.:|..||:..|.:||.||:||:...|  ||.......|:.::.|.|.|.:  :.|.::.| |:.
pombe   737 RNVFEKARNSSPCVIFFDELDSIAPHRGNSSDSGNVMDRVVSQLLAELDSI--SKDNNKYVFVIG 799

  Fly   627 ATNRPQELDEAALR--RFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAK-ITDGYSG 688
            |||||..||.:.||  ||.|.||:.:...:..:..:.|.|.|.....:|..|..:|| ....::|
pombe   800 ATNRPDLLDPSLLRPGRFDKLVYLGINKSEESKASMLRALTKTFKLDETIDLNEIAKNCHPNFTG 864

  Fly   689 SDLTALAKDAALEPIRELNVE-----QVKCLDISAMR-------------AITEQDFHSSLKRIR 735
            :|:.||..||.|..|:....|     |....|:|...             .||::||.:|||::|
pombe   865 ADMYALCSDAVLSAIKRKTNEIDLLIQASGTDLSTEEFFKRNENQDSLELRITKEDFLTSLKKLR 929

  Fly   736 RSVAPQSLNSYE 747
            .|::.|.|:.||
pombe   930 PSISEQELHRYE 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	31/56 (55%)
		AAA	515..652	CDD:214640	63/141 (45%)
		AAA	519..650	CDD:278434	61/135 (45%)
		Vps4_C	<722..754	CDD:286426	13/26 (50%)
pex6	NP_593468.1	SpoVK	426..937	CDD:223540	116/331 (35%)
		AAA	426..544	CDD:278434
		P-loop_NTPase	646..>719	CDD:304359	38/73 (52%)
		AAA	691..824	CDD:278434	61/134 (46%)
		Vps4_C	<912..941	CDD:286426	11/28 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900