Protein Alignment spas and sec18

DIOPT Version :9

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_594690.1
• Gene: sec18 / 2542410
• PomBaseID: SPAC1834.11c
• Length: 792
• Species: Schizosaccharomyces pombe
• Alignment Length: 469
• Identity: 123/469 - (26%)
• Similarity: 192/469 - (40%)
• Gaps: 126/469 - (26%)

  Fly   331 QSKPQKTREPM----LAGMTNEPMKLRVRSSG---------YGPKATTSAQPTASGRKLTIGSKR 382
            |::.:.|.||.    :|.:.....:.:|.|.|         |..|||..   |.|...|.||.
pombe   154 QNRNRTTNEPFDGEEMAKLFCSSYQSQVFSPGQKIVFDFRSYNIKATVR---TISCVDLLIGE-- 213

  Fly   383 PVNLAVANKSQTLPRN-LGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGP 446
              |....|.:.|..|. |.|:|.:     |..|.|.:  |:|.:.|..|         |.:|
pombe   214 --NQDAENTADTSKRGLLTSQTEI-----QFFKAAHS--ALRLKASMTR---------PASN--- 257

  Fly   447 SGSGASTPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQD-----VAKQALQEMVILPSVRP 506
                                     .|::.|.|.|...|.|.|     :.::|....:..|.:..
pombe   258 -------------------------AILQPGFKFEDMGIGGLDSEFSAIFRRAFASRLFPPGMVE 297

  Fly   507 ELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNI-SAASLTSKYVGDGEKLVRALFAV 570
            :|  |:. ..||:||:||||.||||:||.:....:|....| :...:.:||||..|:.||.|||.
pombe   298 KL--GIN-HVKGILLYGPPGTGKTLIARQIGKMLNAREPKIVNGPEILNKYVGQSEENVRKLFAD 359

  Fly   571 ARHMQPS--------IIFIDEVDSLLSERSSS--EHEASRRLKTEFLVEFDGLPGNPDGDRIVVL 625
            |......        ||..||:|::..:|.||  :.....::..:.|.:.||:   ...:.|:|:
pombe   360 AEREYRDRGEESGLHIIIFDELDAICKKRGSSGGDTGVGDQVVNQLLAKMDGV---DQLNNILVI 421

  Fly   626 AATNRPQELDEAALR--RFTKRVYVSLPDEQTRELLL---------NRLLQKQGSPLDTEALRRL 679
            ..|||...:|||.||  |....:.:|||||..|..:|         |.:|:   :.:|.|   .|
pombe   422 GMTNRKDMIDEALLRPGRLEVHMEISLPDEHGRLQILKIHTSRMASNGILE---NDVDME---EL 480

  Fly   680 AKITDGYSGSDLTALAKDA-ALEPIREL----------NVEQVKCLDISAMRAITEQDFHSSLKR 733
            |.:|..:||:::..|.|.| :....|.:          |:|.:|         :...||.::|..
pombe   481 ASLTKNFSGAEIAGLIKSASSFAFYRHIKVGTTAAVSGNLENIK---------VNRNDFLNALSE 536

  Fly   734 IRRS--VAPQSLNS 745
            :|.:  |:.:.|.|
pombe   537 VRPAYGVSEEELES 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	21/60 (35%)
		AAA	515..652	CDD:214640	51/149 (34%)
		AAA	519..650	CDD:278434	47/143 (33%)
		Vps4_C	<722..754	CDD:286426	7/26 (27%)
sec18	NP_594690.1	CDC48_N	61..133	CDD:215012
		CDC48_2	163..235	CDD:215011	21/78 (27%)
		SpoVK	290..791	CDD:223540	82/282 (29%)
		AAA	307..448	CDD:278434	47/143 (33%)
		AAA	581..717	CDD:99707

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900