DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spas and SPBC947.01

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_595275.1	Gene:	SPBC947.01 / 2541249	PomBaseID:	SPBC947.01	Length:	660	Species:	Schizosaccharomyces pombe

Alignment Length:	668	Identity:	222/668 - (33%)
Similarity:	312/668 - (46%)	Gaps:	165/668 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 RAFEYISKALKIDEENEGHKEL--AIELYRKGIKELEDGIAVDCWSGRGDV-------WDRAQRL 290
            |.....|:||..    ||:::.  |...|.|.::|::...|.....|.|.:       |:   .|
pombe     7 RILPIASRALLC----EGNRDWAGAYVSYCKVLEEMKKSSAARDRMGLGPLTGAEACSWN---GL 64

  Fly   291 HDKMQTNLSMARDRLHFLALREQDLQMQRLSLKEKQKEEA-----QSKPQKTREPMLAGMTNEPM 350
            :|...:..|..|.     .:.|.:::.|...|..|..::|     ..:|.:::.|....||...|
pombe    65 YDNCLSKASKLRK-----TILESEMERQNYQLAAKLSKKAPVDLHPLRPVRSQTPAYTPMTTRMM 124

  Fly   351 KLRVR-----------------------------SSGYG------------------PK------ 362
            ..:.|                             ||.||                  |:
pombe   125 YRQTRGAQSEVNLSTPKQIYSKHSPPSTSTSSIVSSSYGDAPSYLAPSKPNRSPPLKPEDPFASF 189

  Fly   363 ---------------ATTSAQPTASGRKLTIGSKRPVNLAVANKSQTLPR----NLGSKTSVGAV 408
                           |:.||..:.:||..|:.|   .....|.|||:..:    |..|..|:...
pombe   190 NSSASAIAAASKSAAASASALSSDTGRSATMNS---TTFPTAMKSQSTTKPTLSNSVSSPSIQVS 251

  Fly   409 QRQPAKTAATP------------PAV-----RRQFSSGRNTPPQRSRTPINNNG---------PS 447
            ..|.|.. :||            |||     ....|.|::........|..|:.         ||
pombe   252 NNQNANN-STPLSFHAPIPPLHVPAVPLTSASHSSSDGKSRKHPSPYKPYLNSSHDTLGSSTRPS 315

  Fly   448 -----GSGASTPVVSV--KGVEQKLVQ---------------------LILDEIVEGGAKVEWTD 484
                 ||.|::|..:.  |.:..|.:.                     .|::||:.....|.|:|
pombe   316 SADTAGSPATSPPATADSKTIVSKTISASTTQQTEPLQQTTPSSDFEYAIMNEIISNHEPVYWSD 380

  Fly   485 IAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISA 549
            |||.|.||.:|:|.||.|.:|||||.|||.|.:|:|||||||.|||:||||||||..|||.:|||
pombe   381 IAGLDDAKNSLKEAVIYPFLRPELFQGLREPVQGMLLFGPPGTGKTMLARAVATEAKATFFSISA 445

  Fly   550 ASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSER--SSSEHEASRRLKTEFLVEFDG 612
            :||||||:||.||||||||.||:....|:||:||:||:||.|  |.:|||:|||||||||:::..
pombe   446 SSLTSKYLGDSEKLVRALFEVAKRQTCSVIFVDEIDSILSARNDSGNEHESSRRLKTEFLIQWSS 510

  Fly   613 LP-GNPD-----GDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPL 671
            |. ..||     ..|::||||||.|..:||||.|||.||.|:.||:::||...|:.||..|...|
pombe   511 LTNAAPDKQTGHSPRVLVLAATNLPWCIDEAARRRFVKRTYIPLPEKETRYKHLSHLLHNQVHCL 575

  Fly   672 DTEALRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRR 736
            ..|.|..|..:|:||||||:||||||||:.|:|.|. :.:.......:..|:...|.:||:.||.
pombe   576 TEEDLEELVNLTEGYSGSDITALAKDAAMGPLRNLG-DALLTTSAEMIPPISLNHFKASLRTIRP 639

  Fly   737 SVAPQSLNSYEKWSQDYG 754
            ||:.:.::.||:|::.:|
pombe   640 SVSQEGIHRYEEWNKQFG 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	18/81 (22%)
		P-loop_NTPase	482..>538	CDD:304359	38/55 (69%)
		AAA	515..652	CDD:214640	89/144 (62%)
		AAA	519..650	CDD:278434	86/138 (62%)
		Vps4_C	<722..754	CDD:286426	11/31 (35%)
SPBC947.01	NP_595275.1	P-loop_NTPase	382..>432	CDD:304359	33/49 (67%)
		AAA	413..556	CDD:214640	88/142 (62%)
		AAA	415..554	CDD:278434	86/138 (62%)
		Vps4_C	<623..657	CDD:286426	11/33 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	159	1.000	Domainoid score	I996
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001088
OrthoInspector	1	1.000	-	-		otm47357
orthoMCL	1	0.900	-	-		OOG6_100722
Panther	1	1.100	-	-	O	PTHR23074
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2807
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.840