DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spas and yta12

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_596797.1	Gene:	yta12 / 2541079	PomBaseID:	SPBC543.09	Length:	773	Species:	Schizosaccharomyces pombe

Alignment Length:	335	Identity:	106/335 - (31%)
Similarity:	167/335 - (49%)	Gaps:	45/335 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   444 NGPSGSGASTPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPEL 508
            :|.:|.|..    .:.|:.:...::...|.   ..|:::.|:||.|.||:.:.|.|.... .|:.
pombe   264 SGAAGGGQG----GIFGIGKSRAKMFNHET---DIKIKFADVAGVDEAKEEIMEFVKFLK-NPKF 320

  Fly   509 F--TGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVA 571
            :  .|.:.| :|.:|.||||.||||||:|.|.|.:..||::|.:.....:||.|...||.|||.|
pombe   321 YERLGAKIP-RGAILSGPPGTGKTLLAKATAGEANVPFLSVSGSEFLEMFVGVGPSRVRDLFATA 384

  Fly   572 RHMQPSIIFIDEVDSLLSER-------SSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATN 629
            |...|.||||||:|::...|       |:.|.|::   ..:.|||.||...:   :.|||.|.||
pombe   385 RKNAPCIIFIDEIDAIGKARGRGGQFGSNDEREST---LNQLLVEMDGFTSS---EHIVVFAGTN 443

  Fly   630 RPQELDEAALR--RFTKRVYVSLPDEQTRELLLNRLLQ--KQGSPLDTEALRRLAKITDGYSGSD 690
            ||..||.|.||  ||.:::.:..||...||.:....|:  |....:|..| :|||.:|.|::|:|
pombe   444 RPDVLDPALLRPGRFDRQITIDRPDIGGREQIFKVHLKHIKAADNIDLIA-KRLAVLTSGFTGAD 507

  Fly   691 LTALAKDAALEPIRELNVEQVKCLDI-SAMRAITEQDFHSSLKRIRRSVAPQSLNSYEK------ 748
            :..:..:.||...|. |..:|:.:.. .|:..:|     :.|::..|.::|:..|:...
pombe   508 IMNVCNEGALIAARS-NSNEVQMVHFEQAIERVT-----AGLEKKSRVLSPEEKNTVAHHEAGHA 566

  Fly   749 ---WSQDYGD 755
               |..:|.|
pombe   567 VAGWFMEYVD 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	24/57 (42%)
		AAA	515..652	CDD:214640	61/145 (42%)
		AAA	519..650	CDD:278434	59/139 (42%)
		Vps4_C	<722..754	CDD:286426	6/40 (15%)
yta12	NP_596797.1	FtsH_ext	136..230	CDD:284011
		FtsH_fam	238..733	CDD:273520	106/335 (32%)
		AAA	333..466	CDD:278434	59/138 (43%)
		Peptidase_M41	548..731	CDD:279742	6/29 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910