DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spas and SPBC16E9.10c

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_595792.1	Gene:	SPBC16E9.10c / 2539968	PomBaseID:	SPBC16E9.10c	Length:	779	Species:	Schizosaccharomyces pombe

Alignment Length:	682	Identity:	179/682 - (26%)
Similarity:	279/682 - (40%)	Gaps:	162/682 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 NSSKEQQQSLNH--PSELNREGDGQEQQLSNQPQRF--RPIQPLEM----AANRPGGGY---SPG 220
            |.||.|:...|.  ||:::....|......|:....  .||:..|:    ..:.|.|..   .||
pombe   154 NGSKRQKAEANREPPSDISLSDIGGLDDCINELLELVAMPIKHPEVYQYTGIHPPRGVLLHGPPG 218

  Fly   221 PGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWD 285
            .|..:||                      |....||.:.........:..|::.:......:|::
pombe   219 CGKTMLA----------------------NALANELGVPFISISAPSIVSGMSGESEKKVREVFE 261

  Fly   286 RAQRLHDKMQTNLSMARDRLHFLALREQDLQ--MQR-------LSLKEKQKEEAQSKPQKTREPM 341
            .|:.|...:     |..|.:..:..:.:..|  |:|       ..:.|...|:...||     .:
pombe   262 EAKSLAPCL-----MFIDEIDAVTPKRESAQREMERRIVAQFLTCMDELSFEKTDGKP-----VL 316

  Fly   342 LAGMTNEPMKL--RVRSSGYGPKATTSAQPTASGRKLTIGSKRPVNLAVANKSQTLPRNLGSKTS 404
            :.|.||.|..|  .:|.:|...:......|:...|:..:              :|:.:  |.|.|
pombe   317 VIGATNRPDSLDSALRRAGRFDREICLTVPSQDAREKIL--------------RTMAK--GLKLS 365

  Fly   405 VGAVQRQPAK--------------TAATPPAVRRQFSSGRNTPPQRSRTPIN----NNGPS---- 447
            .....||.||              .||...|::|.|:         ..:|:|    |:.|.
pombe   366 GDFDFRQLAKQTPGYVGADLKALTAAAGIIAIKRIFN---------EISPLNKLDLNSDPRFNEL 421

  Fly   448 ------GSGASTPVVSVKGVEQKL--------------VQLILDEIVEGGAKVE----------- 481
                  .|..|.|:.....:::.|              :.:...:.:|..|||:
pombe   422 DSDMALDSNDSLPLDHSSIIQRYLNAHPDPLSPEELEPLAICPQDFIEALAKVQPSSKREGFATV 486

  Fly   482 ----WTDIAGQDVAKQALQEMVILPSVRPELF--TGLRAPAKGLLLFGPPGNGKTLLARAVATEC 540
                |.:|......:..||..::.|..||||:  .|:.||. |:||:||||.||||||:|||.|.
pombe   487 PGVSWNNIGALKSIRVELQMAIVQPIKRPELYQSVGISAPT-GVLLWGPPGCGKTLLAKAVANES 550

  Fly   541 SATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTE 605
            .|.|::|....|.:||||:.|:.||.:|..||...|.:||.||:|:::..|..|..|||.|:...
pombe   551 KANFISIRGPELLNKYVGESERAVRQVFLRARASSPCVIFFDELDAMVPRRDDSLSEASSRVVNT 615

  Fly   606 FLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYVSLPDEQTRELLLNRLLQKQG 668
            .|.|.|||   .|...:.|:||||||..:|.|.||  |..|.:.|.|||...|..:| :.|.||
pombe   616 LLTELDGL---SDRSGVYVIAATNRPDIIDPAMLRPGRLDKTLLVDLPDAHERVEIL-KTLTKQ- 675

  Fly   669 SPLDTE----ALRRLAKITDGYSGSDLTALAKDAALEPIR-----ELNVEQVKCLDISAMRAI-- 722
            :||..|    .|.|..:.:: :||:||.||.::||:..:|     ::...:.:....||:..|
pombe   676 TPLHEEVNLDVLGRDERCSN-FSGADLAALVREAAVTALRSAVFADIASNEPEITQHSALEPIRV 739

  Fly   723 TEQDFHSSLKRIRRSVAPQSLNSYE----KWS 750
            |..||..:.|.|:.||:.:....|:    :||
pombe   740 TNADFELAFKNIKPSVSDRDRQKYQRLAKRWS 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	9/77 (12%)
		P-loop_NTPase	482..>538	CDD:304359	27/57 (47%)
		AAA	515..652	CDD:214640	65/138 (47%)
		AAA	519..650	CDD:278434	62/132 (47%)
		Vps4_C	<722..754	CDD:286426	11/35 (31%)
SPBC16E9.10c	NP_595792.1	DnaC	89..>280	CDD:224401	28/152 (18%)
		SpoVK	191..756	CDD:223540	166/628 (26%)
		AAA	211..341	CDD:278434	28/161 (17%)
		AAA	529..659	CDD:278434	62/132 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900