DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and Katnal1

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_705800.1	Gene:	Katnal1 / 231912	MGIID:	2387638	Length:	488	Species:	Mus musculus

Alignment Length:	395	Identity:	152/395 - (38%)
Similarity:	220/395 - (55%)	Gaps:	64/395 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   412 PAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGS--------------------------- 449
            ||:..| ||.:||         |.|...|:..:..:|:
Mouse   104 PAEHRA-PPQIRR---------PNREVRPLRKDVGAGARGLVGRAHQISKSDKPASRDKDYRARG 158

  Fly   450 -----------GAS---TPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVI 500
                       |||   .|.....|.::.||:.:..:||.....:.|.|||..:.||:.|:|.|:
Mouse   159 RDDKARKNVQDGASDSEIPKFDGAGYDKDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVV 223

  Fly   501 LPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVR 565
            ||...|:.|.|:|.|.||:|:.||||.|||:||:||||||..||.|:|:::|||||.|:.|||||
Mouse   224 LPMWMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVR 288

  Fly   566 ALFAVARHMQPSIIFIDEVDSLLSER-SSSEHEASRRLKTEFLVEFDGLPG---NPDGDRIV-VL 625
            .||.:||...|:.|||||:||:.|.| :|.|||||||:|:|.|::.||:.|   |.|..::| ||
Mouse   289 LLFEMARFYAPTTIFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVL 353

  Fly   626 AATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEA-LRRLAKITDGYSGS 689
            ||||.|.::|||..||..||:|:.||..:.|..||...|::  ..||.:. |..:|..|:||||:
Mouse   354 AATNFPWDIDEALRRRLEKRIYIPLPTAKGRAELLKISLRE--VELDPDVHLEDIADKTEGYSGA 416

  Fly   690 DLTALAKDAALEPIRE----LNVEQVKCLDISAMR-AITEQDFHSSLKRIRRSVAPQSLNSYEKW 749
            |:|.:.:||:|..:|.    |:.|:::.|....:: .:|..|...:||:|.:||:...|..||||
Mouse   417 DITNICRDASLMAMRRRINGLSPEEIRALSKEELQMPVTRGDLELALKKIAKSVSAADLEKYEKW 481

  Fly   750 SQDYG 754
            ..::|
Mouse   482 MVEFG 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	30/55 (55%)
		AAA	515..652	CDD:214640	81/141 (57%)
		AAA	519..650	CDD:278434	77/135 (57%)
		Vps4_C	<722..754	CDD:286426	12/31 (39%)
Katnal1	NP_705800.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..179		15/84 (18%)
Katnal1	NP_705800.1	SpoVK	<186..481	CDD:223540	133/296 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910