DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spas and Iqca1l

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_808344.3	Gene:	Iqca1l / 231045	MGIID:	3045319	Length:	825	Species:	Mus musculus

Alignment Length:	684	Identity:	159/684 - (23%)
Similarity:	275/684 - (40%)	Gaps:	153/684 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 IVVQNSSKEQQQSL--NHPSELNREGDGQEQQLSNQPQRFRPIQPLEMAANRPGGGYSPGPGDPL 225
            |:||::.:.:|..|  ....|:.:|.:...:...|..|:|...|. .:...:...||       |
Mouse   165 ILVQSAERARQGRLRATFMREIRKEEERDRRIWENGQQKFSRDQG-AIVIQKVWKGY-------L 221

  Fly   226 LAKQKHHHRRA-FEYI-----------------------SKALKIDEENEGHKELAIELYRK--- 263
            ..|:....||. .|:|                       |:.::..|:.|..:|...:.|..
Mouse   222 QRKRIEQDRRVEMEFIGMLPSPNQTARLNTLNQAFLGEESRRMRQVEKEEEFQEAIGKTYESLTE 286

  Fly   264 ----GIKE-LEDGIA---VDCWSGRG---DVWDRAQ---------------RLHDKMQTNLSMAR 302
                .:|| ::|.|.   ::|.:..|   |..|.|.               ||..:.|...|..:
Mouse   287 TEGPDMKERMKDQIRQWFIECHALTGRFPDYPDEASGGSYLIFADKTPEQVRLDLEAQAQESRKK 351

  Fly   303 DRLHFLALREQDLQMQRLSLKEKQKEEAQSKPQKTREPMLAGMTNEP-MKLRVRSSGYGPKATTS 366
            |            |.::...|||:||:.:.|.:|.:|..   :..|| :..||..|...|.....
Mouse   352 D------------QEKKEKNKEKEKEKKEKKKKKVKEEK---VKKEPEVMFRVLPSKSIPVINAG 401

  Fly   367 AQPTASGRKLTIGSKRPVNLAVANKSQTLPR------NLGSKTSVGAVQRQPAKTAATPPAVRRQ 425
            .:...|..|....:|.|   :....|:||..      .:..:..|..:.||..|....  ||.|:
Mouse   402 HEEYTSVWKSRYDNKHP---SQNFDSETLREEKRKQVEMEIRVQVDELMRQELKNLRL--AVDRE 461

  Fly   426 FSSGRNTPPQRSRTPINNNGPSGSGAS------TPVVSVKGVEQKLVQLILDEIVEGGAKVEWTD 484
            .:....:|.::        |...||..      ||   .:.|:....:|::..:::..|.|..:|
Mouse   462 ETRPLKSPKKK--------GGKKSGKKKKEKDLTP---DRSVDSLFEELVIIGLIKKSALVTLSD 515

  Fly   485 IAGQDV---AKQALQEMVILPSV-----RPELFTGLR---------AP-AKGLLLFGPPGNGKTL 531
            ..|..:   :...|...:.:||:     ...|:..||         || .:.:||.||.|.||.:
Mouse   516 YIGDCLYLGSTLTLANKMPMPSLFDIRQNMALYGVLRLGSHDIHTMAPLVRSILLVGPSGMGKKM 580

  Fly   532 LARAVATECSATFLNISAASLTSKYVG--DGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSS 594
            |.:||.||..|...::|..:|..||.|  ..:.||..:|.|||.:|||:|:|...:....::...
Mouse   581 LVQAVCTETGANLFDLSPDNLMGKYPGKNGAQLLVHIVFKVARLLQPSVIWIGNTEKTFYKKVPK 645

  Fly   595 EHEA--SRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRV-YVSLPDEQTR 656
            |...  .:|:|.:.:.....|  :| |||::::..|.|||..:...|.||.:|: ::..||..:|
Mouse   646 EERTMDPKRIKKDLMRATKQL--SP-GDRVMLIGTTERPQLAEMKGLCRFYERILFIPRPDYASR 707

  Fly   657 ELLLNRLLQKQG------SPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLD 715
            .:|..|:::.||      |.||..|   ||:::|||:.|.:        |:.|:.:..|: :.|.
Mouse   708 YVLWKRMIESQGRGVQLTSSLDVSA---LARVSDGYTPSHI--------LQSIQSVLTER-RLLQ 760

  Fly   716 ISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKW 749
            : ..:.:...:|...|.|: ..|..:...|.::|
Mouse   761 L-IKKPLVASEFVGHLARL-DPVYREEEESLKEW 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	23/130 (18%)
		P-loop_NTPase	482..>538	CDD:304359	20/73 (27%)
		AAA	515..652	CDD:214640	46/142 (32%)
		AAA	519..650	CDD:278434	45/135 (33%)
		Vps4_C	<722..754	CDD:286426	6/28 (21%)
Iqca1l	NP_808344.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..378		12/45 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..487		5/35 (14%)
		SpoVK	<566..745	CDD:223540	62/184 (34%)
		AAA	568..701	CDD:278434	45/135 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900