Protein Alignment spas and Iqca1l

DIOPT Version :10

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_808344.3
• Gene: Iqca1l / 231045
• MGIID: 3045319
• Length: 825
• Species: Mus musculus
• Alignment Length: 684
• Identity: 159/684 - (23%)
• Similarity: 275/684 - (40%)
• Gaps: 153/684 - (22%)

  Fly   163 IVVQNSSKEQQQSL--NHPSELNREGDGQEQQLSNQPQRFRPIQPLEMAANRPGGGYSPGPGDPL 225
            |:||::.:.:|..|  ....|:.:|.:...:...|..|:|...|. .:...:...||       |
Mouse   165 ILVQSAERARQGRLRATFMREIRKEEERDRRIWENGQQKFSRDQG-AIVIQKVWKGY-------L 221

  Fly   226 LAKQKHHHRRA-FEYI-----------------------SKALKIDEENEGHKELAIELYRK--- 263
            ..|:....||. .|:|                       |:.::..|:.|..:|...:.|..
Mouse   222 QRKRIEQDRRVEMEFIGMLPSPNQTARLNTLNQAFLGEESRRMRQVEKEEEFQEAIGKTYESLTE 286

  Fly   264 ----GIKE-LEDGIA---VDCWSGRG---DVWDRAQ---------------RLHDKMQTNLSMAR 302
                .:|| ::|.|.   ::|.:..|   |..|.|.               ||..:.|...|..:
Mouse   287 TEGPDMKERMKDQIRQWFIECHALTGRFPDYPDEASGGSYLIFADKTPEQVRLDLEAQAQESRKK 351

  Fly   303 DRLHFLALREQDLQMQRLSLKEKQKEEAQSKPQKTREPMLAGMTNEP-MKLRVRSSGYGPKATTS 366
            |            |.::...|||:||:.:.|.:|.:|..   :..|| :..||..|...|.....
Mouse   352 D------------QEKKEKNKEKEKEKKEKKKKKVKEEK---VKKEPEVMFRVLPSKSIPVINAG 401

  Fly   367 AQPTASGRKLTIGSKRPVNLAVANKSQTLPR------NLGSKTSVGAVQRQPAKTAATPPAVRRQ 425
            .:...|..|....:|.|   :....|:||..      .:..:..|..:.||..|....  ||.|:
Mouse   402 HEEYTSVWKSRYDNKHP---SQNFDSETLREEKRKQVEMEIRVQVDELMRQELKNLRL--AVDRE 461

  Fly   426 FSSGRNTPPQRSRTPINNNGPSGSGAS------TPVVSVKGVEQKLVQLILDEIVEGGAKVEWTD 484
            .:....:|.::        |...||..      ||   .:.|:....:|::..:::..|.|..:|
Mouse   462 ETRPLKSPKKK--------GGKKSGKKKKEKDLTP---DRSVDSLFEELVIIGLIKKSALVTLSD 515

  Fly   485 IAGQDV---AKQALQEMVILPSV-----RPELFTGLR---------AP-AKGLLLFGPPGNGKTL 531
            ..|..:   :...|...:.:||:     ...|:..||         || .:.:||.||.|.||.:
Mouse   516 YIGDCLYLGSTLTLANKMPMPSLFDIRQNMALYGVLRLGSHDIHTMAPLVRSILLVGPSGMGKKM 580

  Fly   532 LARAVATECSATFLNISAASLTSKYVG--DGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSS 594
            |.:||.||..|...::|..:|..||.|  ..:.||..:|.|||.:|||:|:|...:....::...
Mouse   581 LVQAVCTETGANLFDLSPDNLMGKYPGKNGAQLLVHIVFKVARLLQPSVIWIGNTEKTFYKKVPK 645

  Fly   595 EHEA--SRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRV-YVSLPDEQTR 656
            |...  .:|:|.:.:.....|  :| |||::::..|.|||..:...|.||.:|: ::..||..:|
Mouse   646 EERTMDPKRIKKDLMRATKQL--SP-GDRVMLIGTTERPQLAEMKGLCRFYERILFIPRPDYASR 707

  Fly   657 ELLLNRLLQKQG------SPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLD 715
            .:|..|:::.||      |.||..|   ||:::|||:.|.:        |:.|:.:..|: :.|.
Mouse   708 YVLWKRMIESQGRGVQLTSSLDVSA---LARVSDGYTPSHI--------LQSIQSVLTER-RLLQ 760

  Fly   716 ISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKW 749
            : ..:.:...:|...|.|: ..|..:...|.::|
Mouse   761 L-IKKPLVASEFVGHLARL-DPVYREEEESLKEW 792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	23/130 (18%)
		RecA-like_spastin	484..648	CDD:410932	55/186 (30%)
		AAA_lid_3	676..727	CDD:465537	10/50 (20%)
		Vps4_C	<722..754	CDD:462762	6/28 (21%)
Iqca1l	NP_808344.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	344..378		12/45 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	459..487		5/35 (14%)
		P-loop containing Nucleoside Triphosphate Hydrolases	540..699	CDD:476819	50/161 (31%)