DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spas and Pex6

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_663463.1	Gene:	Pex6 / 224824	MGIID:	2385054	Length:	981	Species:	Mus musculus

Alignment Length:	753	Identity:	203/753 - (26%)
Similarity:	294/753 - (39%)	Gaps:	191/753 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 SLIYQLFC---------IFRYL--------YGASTKVIYRPHRRDCNIEIVVQNSSKEQQQSLNH 178
            :|.:.|.|         |.|||        .|:.:.:...|..|:.:|||:   ||.....:.|:
Mouse   277 TLAFNLGCDPLEVGELRIQRYLEGSIAPENKGSCSPLPGPPFARELHIEIL---SSPHYSANGNY 338

  Fly   179 PSELNR---------EGD-------GQEQQLSNQPQRFRPIQPLEMAANRPGGGYSPGPGDPLLA 227
            ...|.|         |||       ||.:.|....:|....:.:.....:..|....||....||
Mouse   339 DHVLYRHFQTPRVVQEGDVLCVSTAGQVEILEGSLERLPRWREMFFKVKKTVGEAPEGPASAFLA 403

  Fly   228 KQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKG-----IKELEDGIAVDCWSGRGDVWDRA 287
            ...|                          ..||..|     :..|.        |||...||..
Mouse   404 DTTH--------------------------TSLYLAGTALSHVPSLP--------SGRSPPWDSL 434

  Fly   288 QR-------------LHDKMQ-----------------------TNLSMARDR--LHFLALREQD 314
            ..             |...:|                       |.::.|..|  ||.|.:....
Mouse   435 SPPGLEALVNELCAILKPHLQPGGTLLTGTSCVLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSS 499

  Fly   315 LQMQRLSLKEKQKEEAQSKPQKTREPMLAGMTNEPMKLRVRSSGYGPKATTSAQPTASGRKLTIG 379
            |........|.:.:...|:.::.| |.:..:|...:..|.| .|.|    ..|:..|:.|.|.:.
Mouse   500 LCADSSRAVETKLQATFSRARRCR-PAVLLLTAVDLLGRDR-DGLG----EDARVAATLRHLLLD 558

  Fly   380 ----SKRPVNLAVANKS--QTLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSS----GRNTP- 433
                |:.|..:.||..|  |.||.::  :|:.......|..:.|...::.:..::    |:...
Mouse   559 EDALSRCPPLMVVATTSRVQDLPTDV--QTAFPHELEVPVLSEAQRLSILQALTAHLPLGQEVNL 621

  Fly   434 PQRSR----------------------TPINNNGPSGS----------GASTPVVSVKGVEQKLV 466
            ||.:|                      |.|..:|.:|.          .|..|::: :...|.|.
Mouse   622 PQLARRCAGFVVGDLYALLTHTCRAACTRIRASGSAGGLSEEDEGDLCVAGFPLLA-EDFGQALD 685

  Fly   467 QLILDEIVEGGA----KVEWTDIAG-QDVAKQALQEMVILPSVRPELFT-GLRAPAKGLLLFGPP 525
            ||........||    .|.|.|:.| |||.|:.| |.:.||...|||.: |||  ..||||.|||
Mouse   686 QLQTAHSQAVGAPRIPSVSWHDVGGLQDVKKEIL-ETIQLPLEHPELLSLGLR--RSGLLLHGPP 747

  Fly   526 GNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSE 590
            |.||||||:|||||||.|||::....|.:.|||..|:.||.:||.||...|.|||.||:|||...
Mouse   748 GTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPS 812

  Fly   591 RSSSEHEAS--RRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYVSLP 651
            |..|.....  .|:.::.|.|.|||....|   :.|:.|||||..||.|.||  ||.|.|:|...
Mouse   813 RGRSGDSGGVMDRVVSQLLAELDGLHSTQD---VFVIGATNRPDLLDPALLRPGRFDKLVFVGAS 874

  Fly   652 DEQTRELLLNRLLQKQGSPLDTEALRRLAKITD----GYSGSDLTALAKDAALEPI--RELNVEQ 710
            :::..:|   |:|.........||...||.:.|    ..:|:||.:|..||.:..:  |..::|:
Mouse   875 EDRASQL---RVLSAITRKFKLEASVSLANVLDCCPPQLTGADLYSLCSDAMMTALKRRVRDLEE 936

  Fly   711 VKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEK 748
            ...|..||: .:|.:|...:..|::.||:.|.|..|::
Mouse   937 GLELRSSAL-LLTMEDLLQAAARLQPSVSEQELLRYKR 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	17/120 (14%)
		P-loop_NTPase	482..>538	CDD:304359	33/57 (58%)
		AAA	515..652	CDD:214640	69/140 (49%)
		AAA	519..650	CDD:278434	68/134 (51%)
		Vps4_C	<722..754	CDD:286426	8/27 (30%)
Pex6	NP_663463.1	SpoVK	464..968	CDD:223540	159/522 (30%)
		AAA	467..596	CDD:278434	29/136 (21%)
		AAA	744..872	CDD:278434	64/130 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900