Protein Alignment spas and Vps4b

DIOPT Version :9

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_033216.2
• Gene: Vps4b / 20479
• MGIID: 1100499
• Length: 444
• Species: Mus musculus
• Alignment Length: 567
• Identity: 167/567 - (29%)
• Similarity: 255/567 - (44%)
• Gaps: 164/567 - (28%)

  Fly   226 LAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRL 290
            :|....:.::|.:..|||.:  |:..|:.|.|::||:..::..   :.|..:..:||  ...|.:
Mouse     1 MASTNTNLQKAIDLASKAAQ--EDKAGNYEEALQLYQHAVQYF---LHVVKYEAQGD--KAKQSI 58

  Fly   291 HDKMQTNLSMARDRLHFLALREQDLQMQRLSLKEKQKEEAQSKPQKTREPMLAGMTNEPMKLRVR 355
            ..|....|..|.      .|:|.        ||:|:|     ||||
Mouse    59 RAKCTEYLDRAE------KLKEY--------LKKKEK-----KPQK------------------- 85

  Fly   356 SSGYGPKATTSAQPTASGRKLTIGSKRPVNLAVANKSQTLPRNLGSKTSVGAVQRQPAKTAATPP 420
                                       ||
Mouse    86 ---------------------------PV------------------------------------ 87

  Fly   421 AVRRQFSSGRNTPPQRSRTPINNNGPSGSGASTPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDI 485
               ::..||          |::..|....|.:.   |....::||...:...||.....|:|:|:
Mouse    88 ---KEEQSG----------PVDEKGNDSDGEAE---SDDPEKKKLQNQLQGAIVIERPNVKWSDV 136

  Fly   486 AGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATEC-SATFLNISA 549
            ||.:.||:||:|.||||...|.||||.|.|.:|:|||||||.||:.||:|||||. ::||.:||:
Mouse   137 AGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSISS 201

  Fly   550 ASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLP 614
            :.|.||::|:.||||:.||.:||..:||||||||:|||...||.:|.||:||:||||||:..|:
Mouse   202 SDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRSENESEAARRIKTEFLVQMQGV- 265

  Fly   615 GNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRL 679
             ..|.|.|:||.|||.|..||.|..|||.||:|:.||:...|..:....|....:.|.....:.|
Mouse   266 -GVDNDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEAHARAAMFRLHLGSTQNSLTEADFQEL 329

  Fly   680 AKITDGYSGSDLTALAKDAALEPIREL----NVEQVK--------CL-----------DISAMR- 720
            .:.||||||:|::.:.:||.::|:|::    :.::|:        |:           |..|:.
Mouse   330 GRKTDGYSGADISIIVRDALMQPVRKVQSATHFKKVRGPSRADPNCIVNDLLTPCSPGDPGAIEM 394

  Fly   721 -------------AITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDYG 754
                         .::..|...||...:.:|..|.|...:|:::|:|
Mouse   395 TWMDVPGDKLLEPVVSMWDMLRSLSSTKPTVNEQDLLKLKKFTEDFG 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	17/77 (22%)
		P-loop_NTPase	482..>538	CDD:304359	34/55 (62%)
		AAA	515..652	CDD:214640	78/137 (57%)
		AAA	519..650	CDD:278434	75/131 (57%)
		Vps4_C	<722..754	CDD:286426	8/31 (26%)
Vps4b	NP_033216.2	MIT_VPS4	7..69	CDD:239141	16/68 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	77..118		17/143 (12%)
		RecA-like_VPS4	128..298	CDD:410929	96/171 (56%)
		AAA_lid_3	325..366	CDD:407720	12/40 (30%)
		Vps4_C	381..441	CDD:401324	10/59 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910