DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and Y47C4A.1

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001362034.1	Gene:	Y47C4A.1 / 189973	WormBaseID:	WBGene00021615	Length:	388	Species:	Caenorhabditis elegans

Alignment Length:	191	Identity:	52/191 - (27%)
Similarity:	89/191 - (46%)	Gaps:	35/191 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   559 DGEKLVRALFA-VARHMQPSIIFIDEVDSL---------LSERSSSEHEASRRLKTEFLVEFDGL 613
            :|:|.::..|. ||...:..:...:.||.|         :|..|..|.:...:|    |||.|.:
Worm    22 EGKKQLKIKFKDVAGCSEAKVEIREFVDYLKNPGRFTVGISGGSGEEEQTLNQL----LVEMDRM 82

  Fly   614 PGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYVSLPDEQTRELLLNRLLQKQGSPLD---T 673
             |:.:| .:||||:|||...||:|.||  ||.:.:.:.||....|:.:....::|  ..||   .
Worm    83 -GSGNG-AVVVLASTNRADVLDKALLRPGRFDRHISIDLPTVLERKDMFELYMRK--IKLDHAPQ 143

  Fly   674 EALRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRI 734
            |..:|||.:|..::|:|:..:..::|:.....      ||      ..:|.:|...:|.|:
Worm   144 EYSQRLAVLTPSFTGADIMNVCNESAIRAASN------KC------HVVTIKDMEYALDRV 192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359
		AAA	515..652	CDD:214640	33/104 (32%)
		AAA	519..650	CDD:278434	32/102 (31%)
		Vps4_C	<722..754	CDD:286426	4/13 (31%)
Y47C4A.1	NP_001362034.1	FtsH_fam	24..370	CDD:273520	51/189 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910