DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and Nsf

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_032766.2	Gene:	Nsf / 18195	MGIID:	104560	Length:	744	Species:	Mus musculus

Alignment Length:	331	Identity:	91/331 - (27%)
Similarity:	150/331 - (45%)	Gaps:	74/331 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   476 GGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATEC 540
            ||...|::||     .::|....|..|.:..::  |.: ..||:||:||||.|||||||.:
Mouse   221 GGLDKEFSDI-----FRRAFASRVFPPEIVEQM--GCK-HVKGILLYGPPGCGKTLLARQI---- 273

  Fly   541 SATFLN------ISAASLTSKYVGDGEKLVRALFAVARHMQP--------SIIFIDEVDSLLSER 591
             ...||      ::...:.:||||:.|..:|.|||.|...|.        .||..||:|::..:|
Mouse   274 -GKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQR 337

  Fly   592 -----SSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYVS 649
                 |:..|:.   :..:.|.:.||:   ...:.|:|:..||||..:|||.||  |...::.:.
Mouse   338 GSMAGSTGVHDT---VVNQLLSKIDGV---EQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIG 396

  Fly   650 LPDEQTRELLLN----RLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIR------ 704
            ||||:.|..:|:    |:...|....|.: ::.||..|..:||::|..|.:.|....:.
Mouse   397 LPDEKGRLQILHIHTARMRGHQLLSADVD-IKELAVETKNFSGAELEGLVRAAQSTAMNRHIKAS 460

  Fly   705 ---ELNVEQVKCLDISAMRAITEQDFHSSLKR--------IRRSVAPQSLNSYEKWSQ------D 752
               |:::|:.:.|.      :|..||.:||:.        .:...|...:|...||..      |
Mouse   461 TKVEVDMEKAESLQ------VTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLD 519

  Fly   753 YGDITI 758
            .|::.:
Mouse   520 DGELLV 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	21/55 (38%)
		AAA	515..652	CDD:214640	52/157 (33%)
		AAA	519..650	CDD:278434	49/151 (32%)
		Vps4_C	<722..754	CDD:286426	10/45 (22%)
Nsf	NP_032766.2	CDC48_N	6..83	CDD:215012
		CDC48_2	111..183	CDD:215011
		AAA	254..399	CDD:214640	52/155 (34%)
		AAA	256..397	CDD:278434	49/151 (32%)
		AAA	538..670	CDD:214640
		AAA	539..668	CDD:278434
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900