DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spas and prx-1

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_510386.2	Gene:	prx-1 / 181538	WormBaseID:	WBGene00004191	Length:	996	Species:	Caenorhabditis elegans

Alignment Length:	730	Identity:	174/730 - (23%)
Similarity:	285/730 - (39%)	Gaps:	189/730 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 IVVQNSSKEQQQSLNHPSELNREGDGQEQQLSNQPQRFRPIQPLEMAANRPGGGYSPGP------ 221
            |.::|.|.|...||:|..|        ..||.|:.........||...|....|.:...
Worm   288 IYLRNQSNELDASLSHMFE--------SLQLENRCHCVEGTNTLEPYMNIKIFGVTQNRICTLRY 344

  Fly   222 GDPLLAKQKHHHRRAFE---YISKALKIDEENEGHKEL---AIELYRKGIKELEDGIAVDCWSGR 280
            .:.::.|:.....:.||   .::|:|        |.||   .|.|..:| |||:  :|||
Worm   345 CEIMMEKETFQWVKEFELTNVLTKSL--------HSELQGNPILLSVEG-KELD--VAVD----- 393

  Fly   281 GDVWDRAQRLH--DKMQTNLSMARDRLHFLALREQDLQMQRL-SLKE------------KQKEEA 330
                |:|.||.  ..|:..:....:...||.....:|..|:| .||:            |:.|||
Worm   394 ----DKAIRLKVVPSMKGLVKRVTENTCFLFDLTTELIFQQLGDLKQKHGDTENTRRRRKRTEEA 454

  Fly   331 QSKPQKTREPMLAGMTN-----EPMKLRVRS----------------------SGYGPKATTSAQ 368
            ::..|..::|..:.|.|     ....:::.|                      .|.|...||..:
Worm   455 EASEQIPQKPETSTMENFGFAQNKHFVQIGSHSKLLSELDKVCCGGKQHVMVLGGNGSGKTTFIK 519

  Fly   369 PTASGRKLTIGS----------------------------------KRPVNLAVANKSQTLP--- 396
            ..|  |:|:..|                                  |:|..|.:.:....||
Worm   520 KLA--RRLSHNSSVTFCKMVPCALLKGRSADIIEKLLSDTLHEMEVKKPSCLFLDDFDVILPQID 582

  Fly   397 ---RNLGSKTSVGAVQRQPAKTAATPPAVRRQFSS---GRNTPPQRSRTPINN------------ 443
               |:|..:..|....::...|..:...|.::.||   |......|:|..::.
Worm   583 QEQRHLAMEKVVSVFAQKLRTTEVSVVLVAQRLSSLNDGFVEQVMRARPIVSRKIELEQLTKEDR 647

  Fly   444 --------NGPSGSGASTPVV----------------------SVKGVE-------QKLVQLI-- 469
                    :.|..|...:.:|                      ::|||:       :|..:..
Worm   648 CEIFETFLDLPENSDIISEIVKKSDGYTFSEIEKLAVSINVECAIKGVKYITEIEVEKAFECFVA 712

  Fly   470 --LDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAP-AKGLLLFGPPGNGKTL 531
              :.:|.:|.......|:.|....|:.|::::|.|...|:||..:..| :||:||.||.|.||||
Worm   713 GKMGKIEDGQVLPTMEDVGGMFEQKKLLEQVIIWPRKYPQLFESVGVPVSKGILLHGPSGCGKTL 777

  Fly   532 LARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEH 596
            ||.|..:..:.:.:|:....|.|||:|..|:.||.:|..||...|.|:|.||:|||..:|.....
Worm   778 LANATISNSNFSVVNVKGPELLSKYIGASEENVRLVFEKARSCAPCILFFDELDSLAPKRGHDST 842

  Fly   597 EASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYVSLPDEQTRELL 659
            ..:.|:..:.|.|.||..|...|  :::|..|:|...:|:|.||  ||...||...| |:|..|.
Worm   843 GVTDRVVNQLLTELDGAEGGMKG--VIILGCTSRIDLIDDALLRPGRFDHHVYCGHP-EKTERLD 904

  Fly   660 LNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQ--VKCLDISAMRAI 722
            :.::|..:..|.|.: ...||:.|||:||:||..|..:|.....|::..|:  ::..::...:|.
Worm   905 IMKVLTNKLKPTDVD-FECLAQKTDGWSGADLQLLFTNAQFYNARQIAKEEDGLEEDNVPIDQAS 968

  Fly   723 TEQDFHSSLKRIRRS 737
            .|..|:.|:.:.:||
Worm   969 IESVFNDSIPKPKRS 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	21/85 (25%)
		P-loop_NTPase	482..>538	CDD:304359	24/56 (43%)
		AAA	515..652	CDD:214640	54/139 (39%)
		AAA	519..650	CDD:278434	51/132 (39%)
		Vps4_C	<722..754	CDD:286426	5/16 (31%)
prx-1	NP_510386.2	PEX-1N	103..179	CDD:370392
		P-loop_NTPase	481..>522	CDD:393306	5/40 (13%)
		SpoVK	511..938	CDD:223540	110/432 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000