Protein Alignment spas and spas-1

DIOPT Version :10

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001256115.1
• Gene: spas-1 / 179300
• WormBaseID: WBGene00016045
• Length: 512
• Species: Caenorhabditis elegans
• Alignment Length: 513
• Identity: 198/513 - (38%)
• Similarity: 294/513 - (57%)
• Gaps: 57/513 - (11%)

  Fly   284 WDR-AQRLHD---KMQTNLSMARDRLHFLALREQ----DLQMQ-RLSLKE--------------- 324
            :|| ||:..|   ||:..:.|.....|..:::|:    :|..: |..|||
 Worm    14 YDRVAQKFQDGYEKMRAAIEMDELTKHAGSIQEKLRTAELYKEARSLLKEANEFNIMDIPETRRS 78

  Fly   325 --KQKEEAQSKPQKTREPMLAGMTNE--PMKLRVRSSGYGP-KATTSAQPTASGRKLTIGSKRPV 384
              :.|.:...|.:|:.:..|..:.||  |...:.||:..|| :..::|:.|....:.|...|:
 Worm    79 EIRDKRQNMMKLEKSAQDRLIAICNEVDPNVKQSRSATVGPSRPASAARVTPRPTRATAPEKK-- 141

  Fly   385 NLAVANKSQTLPRNLGSKTSVGAVQRQP-AKTAAT----PP--AVRRQFSSGRNTPPQRSRTPIN 442
            |.|.| |.....|::.|:........|| .|.:.|    ||  |..|:..:.:.....::..|::
 Worm   142 NAAKA-KENDENRHVCSRGDRCGAHHQPVTKKSDTVHPEPPVQASNRKMETVKRVKVDKASLPMH 205

  Fly   443 NNGPSGSGASTPV---VSVKGVEQKLVQLILDEIVEG-GAKVEWTDIAGQDVAKQALQEMVILPS 503
            .|         ||   ..:.||::.:.:.:|||:::. |.:::  |:||...||.||:|.||||:
 Worm   206 QN---------PVNRAALLNGVDKVIGERLLDEVLDNTGVRMD--DVAGCHSAKAALEEAVILPA 259

  Fly   504 VRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALF 568
            :.|.||.|||.|.||:||||||||||||||:|||.|....|.||||:|||||:|||.||.:|.||
 Worm   260 LNPNLFKGLRQPVKGILLFGPPGNGKTLLAKAVAGESKQMFFNISASSLTSKWVGDSEKTIRGLF 324

  Fly   569 AVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQE 633
            .:||:.|||||||||:||:|.|||..:.|.|||:||||||:|||...:.| |||:|:.|||||.|
 Worm   325 QIARNAQPSIIFIDEIDSILCERSEKDAEVSRRMKTEFLVQFDGATSSAD-DRILVIGATNRPHE 388

  Fly   634 LDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQG--SPLDTEALRRLAKITDGYSGSDLTALAK 696
            ||:|.||||.||:.::||||:.|:.|:.:.|:|..  ..|.:..:|.:|..|.|:|.|||.||.|
 Worm   389 LDDAVLRRFPKRIMLNLPDEEARKELITKTLKKHNMMDGLISSDIRYIASNTSGFSNSDLVALCK 453

  Fly   697 DAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDYG 754
            :||:.||||::..::...|...:|.|...||.::|:.||.|.:.:.::....:|:.:|
 Worm   454 EAAMVPIREIDRSKLSMTDGEKIRKIRASDFDTALRTIRPSTSQKIMSKLSDFSRSFG 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	9/27 (33%)
		RecA-like_spastin	484..648	CDD:410932	107/163 (66%)
		AAA_lid_3	676..727	CDD:465537	20/50 (40%)
		Vps4_C	<722..754	CDD:462762	8/31 (26%)
spas-1	NP_001256115.1	cell_div_CdvC	175..510	CDD:468935	158/346 (46%)
		P-loop containing Nucleoside Triphosphate Hydrolases	240..401	CDD:476819	106/161 (66%)