Protein Alignment spas and spas-1

DIOPT Version :9

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001256115.1
• Gene: spas-1 / 179300
• WormBaseID: WBGene00016045
• Length: 512
• Species: Caenorhabditis elegans
• Alignment Length: 513
• Identity: 198/513 - (38%)
• Similarity: 294/513 - (57%)
• Gaps: 57/513 - (11%)

  Fly   284 WDR-AQRLHD---KMQTNLSMARDRLHFLALREQ----DLQMQ-RLSLKE--------------- 324
            :|| ||:..|   ||:..:.|.....|..:::|:    :|..: |..|||
 Worm    14 YDRVAQKFQDGYEKMRAAIEMDELTKHAGSIQEKLRTAELYKEARSLLKEANEFNIMDIPETRRS 78

  Fly   325 --KQKEEAQSKPQKTREPMLAGMTNE--PMKLRVRSSGYGP-KATTSAQPTASGRKLTIGSKRPV 384
              :.|.:...|.:|:.:..|..:.||  |...:.||:..|| :..::|:.|....:.|...|:
 Worm    79 EIRDKRQNMMKLEKSAQDRLIAICNEVDPNVKQSRSATVGPSRPASAARVTPRPTRATAPEKK-- 141

  Fly   385 NLAVANKSQTLPRNLGSKTSVGAVQRQP-AKTAAT----PP--AVRRQFSSGRNTPPQRSRTPIN 442
            |.|.| |.....|::.|:........|| .|.:.|    ||  |..|:..:.:.....::..|::
 Worm   142 NAAKA-KENDENRHVCSRGDRCGAHHQPVTKKSDTVHPEPPVQASNRKMETVKRVKVDKASLPMH 205

  Fly   443 NNGPSGSGASTPV---VSVKGVEQKLVQLILDEIVEG-GAKVEWTDIAGQDVAKQALQEMVILPS 503
            .|         ||   ..:.||::.:.:.:|||:::. |.:::  |:||...||.||:|.||||:
 Worm   206 QN---------PVNRAALLNGVDKVIGERLLDEVLDNTGVRMD--DVAGCHSAKAALEEAVILPA 259

  Fly   504 VRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALF 568
            :.|.||.|||.|.||:||||||||||||||:|||.|....|.||||:|||||:|||.||.:|.||
 Worm   260 LNPNLFKGLRQPVKGILLFGPPGNGKTLLAKAVAGESKQMFFNISASSLTSKWVGDSEKTIRGLF 324

  Fly   569 AVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQE 633
            .:||:.|||||||||:||:|.|||..:.|.|||:||||||:|||...:.| |||:|:.|||||.|
 Worm   325 QIARNAQPSIIFIDEIDSILCERSEKDAEVSRRMKTEFLVQFDGATSSAD-DRILVIGATNRPHE 388

  Fly   634 LDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQG--SPLDTEALRRLAKITDGYSGSDLTALAK 696
            ||:|.||||.||:.::||||:.|:.|:.:.|:|..  ..|.:..:|.:|..|.|:|.|||.||.|
 Worm   389 LDDAVLRRFPKRIMLNLPDEEARKELITKTLKKHNMMDGLISSDIRYIASNTSGFSNSDLVALCK 453

  Fly   697 DAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDYG 754
            :||:.||||::..::...|...:|.|...||.::|:.||.|.:.:.::....:|:.:|
 Worm   454 EAAMVPIREIDRSKLSMTDGEKIRKIRASDFDTALRTIRPSTSQKIMSKLSDFSRSFG 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	9/27 (33%)
		P-loop_NTPase	482..>538	CDD:304359	37/55 (67%)
		AAA	515..652	CDD:214640	90/136 (66%)
		AAA	519..650	CDD:278434	86/130 (66%)
		Vps4_C	<722..754	CDD:286426	8/31 (26%)
spas-1	NP_001256115.1	flhF	105..>298	CDD:235570	72/206 (35%)
		SpoVK	<209..498	CDD:223540	149/291 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159013
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8970
Inparanoid	1	1.050	293	1.000	Inparanoid score	I1679
Isobase	1	0.950	-	0	Normalized mean entropy	S1340
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1176820at2759
OrthoFinder	1	1.000	-	-		FOG0001088
OrthoInspector	1	1.000	-	-		oto19265
orthoMCL	1	0.900	-	-		OOG6_100722
Panther	1	1.100	-	-	LDO	PTHR23074
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2807
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.880