Protein Alignment spas and figl-1

DIOPT Version :10

• Sequence 1: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_504197.1
• Gene: figl-1 / 178829
• WormBaseID: WBGene00017981
• Length: 594
• Species: Caenorhabditis elegans
• Alignment Length: 634
• Identity: 213/634 - (33%)
• Similarity: 319/634 - (50%)
• Gaps: 110/634 - (17%)

  Fly   145 GASTKVIYRPHRRDCNIEIVVQNSSKEQQQ-----SLNHPSELNREGDG---QEQQLSNQPQRFR 201
            |.|...|.:|.|:     |||:..|...||     |.:..:.|:.|.||   .|.:.......|.
 Worm    38 GISPYFIGKPRRK-----IVVETPSDSAQQQPPFKSRSQQNGLDDELDGIIIDEDEDRTVDVSFS 97

  Fly   202 PIQPLEMAANRP--GGGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKG 264
            ..|......:||  |...|...|:  :.|.|...||...:..:......:::
 Worm    98 QKQDTRKLKSRPFLGEKSSFKLGE--IPKPKEEKRREEPFTMRGFDFGSDDK------------- 147

  Fly   265 IKELEDGIA--VDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREQDLQMQRLSLKEKQK 327
            :.::.|.|.  ||..:.|....:..:::|:.....:.:|.:. ||
 Worm   148 VTKIRDKICDIVDPTNARRTDPNFIRQMHENTLKGIEVASNP-HF-------------------- 191

  Fly   328 EEAQSKPQKTREPMLAGMTNEPMKLRVRSSGYGPKATTSAQPTASGRKLTIGSKRPVNLAVANKS 392
                   :|||.|     |.....::.......|..||:|.......|..:...|.
 Worm   192 -------KKTRAP-----TKNRAAIQNTLGTLYPSFTTAAGQDPQNSKFQVPLDRQ--------- 235

  Fly   393 QTLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTP--PQRSRTPINNNG----PSGSGA 451
                   .|..|:|::       |..|||        |..|  |:|...|:....    ..|.|.
 Worm   236 -------SSSQSIGSL-------AGIPPA--------RRAPDIPKRCSNPLIRKAMGMDTEGGGK 278

  Fly   452 STPV------VSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFT 510
            ...:      .::|..::.::.||..||:....::.|.|:||.:.||:||:|:|:||..||::||
 Worm   279 DEKMSGLRAEPTLKHFDENIISLIESEIMSVNNEIGWADVAGLEGAKKALREIVVLPFKRPDVFT 343

  Fly   511 GLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQ 575
            |:|||.||:|||||||.|||::.|.||::|.|||.||||:|||||:||:|||||||||:|||...
 Worm   344 GIRAPPKGVLLFGPPGTGKTMIGRCVASQCKATFFNISASSLTSKWVGEGEKLVRALFSVARLKL 408

  Fly   576 PSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALR 640
            ||:|||||:|||||.||.||||:|||:||||||:.||:...|| :|::||.||||||||||||.|
 Worm   409 PSVIFIDEIDSLLSSRSESEHESSRRIKTEFLVQLDGVNTAPD-ERLLVLGATNRPQELDEAARR 472

  Fly   641 RFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIRE 705
            ||.||:|::||:.::|..::..||......:....|.|:.::||||||:|:..|..:||:.|||:
 Worm   473 RFQKRLYIALPEPESRTQIVQNLLVGTRHDITNHNLERIRELTDGYSGADMRQLCTEAAMGPIRD 537

  Fly   706 LNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDYG 754
            :. :.::.:|...:||:|..||..:.:.:|.:|....|::|..|.:.:|
 Worm   538 IG-DDIETIDKDDIRAVTVMDFAEAARVVRPTVDDSQLDAYAAWDKKFG 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	11/79 (14%)
		RecA-like_spastin	484..648	CDD:410932	112/163 (69%)
		AAA_lid_3	676..727	CDD:465537	19/50 (38%)
		Vps4_C	<722..754	CDD:462762	8/31 (26%)
figl-1	NP_504197.1	P-loop containing Nucleoside Triphosphate Hydrolases	295..480	CDD:476819	117/185 (63%)
		AAA_lid_3	507..552	CDD:465537	16/45 (36%)
		Vps4_C	<545..585	CDD:462762	11/39 (28%)