DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and mspn-1

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_501860.1	Gene:	mspn-1 / 177896	WormBaseID:	WBGene00010557	Length:	342	Species:	Caenorhabditis elegans

Alignment Length:	303	Identity:	108/303 - (35%)
Similarity:	173/303 - (57%)	Gaps:	34/303 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   457 SVKGVEQKLVQLILDEIVE-------------GGAKV--EWTDIAGQDVAKQALQEMVILPSVRP 506
            |.|.|.|...:|.:|..:|             ||..|  :|.:|.|.:.....|::.:||| :|.
Worm    42 SKKKVAQLFHELGIDRQIELSEHEIRIATQFVGGEDVGADWDEIGGCEELVAELKDRIILP-LRF 105

  Fly   507 ELFTG--LRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFA 569
            ...:|  |.:|.:|:||:||||.||||||:|||......|:|:..::||.|:.|:.:||..|:|:
Worm   106 ASQSGSHLLSPPRGILLYGPPGCGKTLLAKAVARAAGCRFINLQVSNLTDKWYGESQKLAAAVFS 170

  Fly   570 VARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQEL 634
            ||:..||:||||||:||.|.:|.|.:||::..:|.:|:..:||.  :..||:|:|:.|||||:::
Worm   171 VAQKFQPTIIFIDEIDSFLRDRQSHDHESTAMMKAQFMTLWDGF--SSSGDQIIVMGATNRPRDV 233

  Fly   635 DEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAA 699
            |.|.|||.|.|..|.:|:.:.|..:||.:|:.: ...:|..|..:|:..:|.|||||..:.:.|.
Worm   234 DAAILRRMTARFQVPVPNAKQRSQILNVILRNE-KINNTVNLGEIAQAAEGLSGSDLKEVCRLAL 297

  Fly   700 LEPIREL-----NVEQVKCLDISAMRAITEQDFHSSLKRIRRS 737
            |...:..     :|.|:..|:        :.||.|::.:..|:
Worm   298 LARAKATVASGGSVNQLLPLE--------QSDFESAVHKYMRA 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	26/57 (46%)
		AAA	515..652	CDD:214640	65/136 (48%)
		AAA	519..650	CDD:278434	63/130 (48%)
		Vps4_C	<722..754	CDD:286426	4/16 (25%)
mspn-1	NP_501860.1	AAA	116..244	CDD:214640	63/129 (49%)
mspn-1	NP_501860.1	AAA	120..249	CDD:278434	63/130 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910