DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and rpt-6

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_499609.1	Gene:	rpt-6 / 176661	WormBaseID:	WBGene00004506	Length:	416	Species:	Caenorhabditis elegans

Alignment Length:	439	Identity:	127/439 - (28%)
Similarity:	203/439 - (46%)	Gaps:	76/439 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 PKATTS-----AQPTASGRKLTIGSKR------------PVNLAVANKSQTLPR------NLGSK 402
            |.|:|:     ::|||  :|||..|..            .....||:|||.:.|      .|.:|
Worm     3 PPASTASSADPSKPTA--QKLTEESDEKTLRKYFSTKVDDAQQKVADKSQNVRRLQAQRNELNTK 65

  Fly   403 TSV-----------GAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPIN--NNGPSGSGASTP 454
            ..:           |:...:.:|.......:.:....|:..........||  |.|...:..:..
Worm    66 VRMLKEELQQLHEQGSYVGEVSKAMDKKKVLVKVHPEGKYVVDVDKSIDINSLNTGARVALRADS 130

  Fly   455 VVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLR-APAKG 518
            ....|.:..|:..|:...:||......:..:.|.|...:.::|::.||...||||..|. |..||
Worm   131 YALHKLLPNKVDPLVSLMMVEKVPDSTYEMVGGLDKQIKEIKEVIELPVKHPELFDALGIAQPKG 195

  Fly   519 LLLFGPPGNGKTLLARAVA--TECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFI 581
            :|||||||.||||||||||  |||  ||:.:|.:.|..|::|:|.::||.||.:||...|||||:
Worm   196 VLLFGPPGTGKTLLARAVAHHTEC--TFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFM 258

  Fly   582 DEVDSLLSER---SSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALR--R 641
            ||:||:.|.|   ||......:|...|.|.:.||.....:   |.|:.||||...||.|.||  |
Worm   259 DEIDSIGSSRVEGSSGGDSEVQRTMLELLNQLDGFEATKN---IKVIMATNRIDILDPALLRPGR 320

  Fly   642 FTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRR---LAKITD---GYSGSDLTALAKDAAL 700
            ..:::....|||:.|..:|....:|..       |.|   :|||.:   |.||:::.::..:|.:
Worm   321 IDRKIEFPAPDEKARADILKIHSRKMN-------LMRGINMAKIAEQIPGASGAEVKSVCTEAGM 378

  Fly   701 EPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKW 749
            ..:||..:.            :|::||..::.::.:..:.::::..:.|
Worm   379 FALRERRIH------------VTQEDFEMAVGKVMQKDSEKNMSIKKLW 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	30/58 (52%)
		AAA	515..652	CDD:214640	65/143 (45%)
		AAA	519..650	CDD:278434	63/137 (46%)
		Vps4_C	<722..754	CDD:286426	4/28 (14%)
rpt-6	NP_499609.1	RPT1	10..414	CDD:224143	123/429 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910