DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spas and ymel-1

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001366715.1	Gene:	ymel-1 / 176460	WormBaseID:	WBGene00010842	Length:	723	Species:	Caenorhabditis elegans

Alignment Length:	488	Identity:	136/488 - (27%)
Similarity:	205/488 - (42%)	Gaps:	104/488 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 NLSMARDRLHFLALREQDLQMQRLSLKEKQKEEAQSKPQKTREPMLAGMTNEPMKLRVRSSGYGP 361
            |..:.|:..:.:..:..|::....||.....:..:.....|..|:.....|..::....|.....
Worm    15 NTGLLRNSRNGINRKPLDIEATAASLSRVYHQVWRQFSSDTSSPVTINQMNNILRDSTLSRRIAR 79

  Fly   362 KATTSAQ---------PTASG----------RKLTIG-----------SKRPVNL---AVANKSQ 393
            |:..|..         |.:|.          ||.|.|           .|.|:..   .:|.|.|
Worm    80 KSEISLNYDDAVVRIIPASSSFYIQRRGFRTRKQTFGVGNAGKPTQDEVKSPLTYFSELLAGKKQ 144

  Fly   394 TLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSG-RNTPPQRSRT-------PINNNGPSGSG 450
                    |||.|.|::.            .|:.|. :..|..:.||       .:.:||.||:|
Worm   145 --------KTSEGGVEKW------------NQYESDLKKLPENQQRTYTDGFVKGLLSNGVSGAG 189

  Fly   451 AS-----------------------TPVVSVKGVEQKLVQLIL---DEIVEGGAKVEWTDIAGQD 489
            ..                       |..:.|:..::::..|..   .|:.....:|.:.|:.|.|
Worm   190 KDGKKSNTLTRFYIFLVFCIFFGYLTGRIRVRVGDRQIGSLFFSNPQEVNPEDVQVTFDDVRGMD 254

  Fly   490 VAKQALQEMV-ILPSVRPELFT--GLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAAS 551
            .||..::|:| .|..  ||.::  |.|.| ||:||.||||.||||||||:|.|....|.:.:.:.
Worm   255 EAKLEVEEIVDYLKD--PEKYSRLGGRLP-KGVLLVGPPGTGKTLLARAIAGEAQVPFFHTAGSE 316

  Fly   552 LTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSER-SSSEHEASRRLKTEFLVEFDGLPG 615
            .....||.|.:.||.||..|:...|.||||||:||:.|:| |:|.|..:.:...:.|.|.||...
Worm   317 FDEVLVGQGARRVRDLFDKAKARAPCIIFIDEIDSVGSKRVSNSIHPYANQTINQLLSEMDGFTR 381

  Fly   616 NPDGDRIVVLAATNRPQELDEAALR--RFTKRVYVSLPDEQTRELLLNRLLQK--QGSPLDTEAL 676
            |   :.|:|:|||||..:||:|.||  ||..||.|..||...|..:.|..|.|  ....:|.:.
Worm   382 N---EGIIVIAATNRVDDLDKALLRPGRFDVRVTVPKPDLAGRVDIFNFYLSKIVHSGGIDPKV- 442

  Fly   677 RRLAKITDGYSGSDLTALAKDAALEPIRELNVE 709
              |||.:.|::|:|:..:...|||:...:..||
Worm   443 --LAKGSTGFTGADIENMVNQAALKAATDNAVE 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	2/10 (20%)
		P-loop_NTPase	482..>538	CDD:304359	29/58 (50%)
		AAA	515..652	CDD:214640	64/139 (46%)
		AAA	519..650	CDD:278434	61/133 (46%)
		Vps4_C	<722..754	CDD:286426
ymel-1	NP_001366715.1	FtsH_fam	195..685	CDD:273520	99/288 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910