DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spas and mac-1

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_496814.1	Gene:	mac-1 / 174974	WormBaseID:	WBGene00003119	Length:	813	Species:	Caenorhabditis elegans

Alignment Length:	739	Identity:	165/739 - (22%)
Similarity:	294/739 - (39%)	Gaps:	198/739 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 EIVVQNSSKEQQ--QSLNHPSELNREGDGQEQQLSNQPQRFRPIQPLEMAANR-----PGGGYSP 219
            |:|:.:.|::::  :.|....|..:.....:..|:...::..|..|:....|:     ||...:|
Worm   118 EVVLSDDSEDERAARQLEKQIESLKTNRANKTVLNLYTKKSAPSTPVSTPKNQATKKPPGASAAP 182

  Fly   220 -----GPG---DPLLAKQKHHHRRAFEYISKA----------------------LKID------- 247
                 |.|   |.:..::.|   ..||:|..|                      |.:|
Worm   183 PALPRGLGAVSDTISPRESH---VKFEHIGGADRQFLEVCRLAMHLKRPKTFATLGVDPPRGFIV 244

  Fly   248 ------------EENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHD--KMQTNL 298
                        :...|  ||||.:.:....||..|::       |:..::.:||.|  |..:..
Worm   245 HGPPGCGKTMFAQAVAG--ELAIPMLQLAATELVSGVS-------GETEEKIRRLFDTAKQNSPC 300

  Fly   299 SMARDRLHFLALREQDLQMQRLSLKEKQKEEAQSKPQKTREPMLAGMTNEPMKLRVRSSGYGPKA 363
            .:..|.:..:|.|.:..|       .:.:....|:...:.:.::.....:|:|.::.....|..|
Worm   301 ILILDDIDAIAPRRETAQ-------REMERRVVSQLCSSLDELVLPPREKPLKDQLTFGDDGSVA 358

  Fly   364 TTSAQPTASGR-KLTIG-SKRP------------------------------------VNLA--- 387
            .....|||:|. .|.|| :.||                                    ||||
Worm   359 IIGDSPTAAGAGVLVIGTTSRPDAVDGGLRRAGRFENEISLGIPDETAREKILEKICKVNLAGDV 423

  Fly   388 -VANKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGA 451
             :...::..|..:|:  .:.|:.|:.||.     |:.|.|.:          ..:.|.|...
Worm   424 TLKQIAKLTPGYVGA--DLQALIREAAKV-----AIDRVFDT----------IVVKNEGHKN--- 468

  Fly   452 STPVVSVKGVEQKLVQLI-----------LDEI-----------------VEGGAK--------- 479
                ::|:.::::|.:::           |.|:                 ::..||
Worm   469 ----LTVEQIKEELDRVLAWLQGDDDPSALSELNGGLQISFEDFERALSTIQPAAKREGFATVPD 529

  Fly   480 VEWTDIAGQDVAKQALQEMVILPSVRPELFT--GLRAPAKGLLLFGPPGNGKTLLARAVATECSA 542
            |.|.||......::.|:..::.|..|.:.|.  |:....:|:||.||||.||||||:|||.|...
Worm   530 VSWDDIGALVEVRKQLEWSILYPIKRADDFAALGIDCRPQGILLCGPPGCGKTLLAKAVANETGM 594

  Fly   543 TFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFL 607
            .|:::....|.:.|||:.|:.||.:|..||..||.:||.||:|:|:.:||..|.....||..:.|
Worm   595 NFISVKGPELLNMYVGESERAVRTVFQRARDSQPCVIFFDEIDALVPKRSHGESSGGARLVNQLL 659

  Fly   608 VEFDGLPGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYVSLPDEQTRELLLNRLLQK---- 666
            .|.||:.|.   .::.::.|||||..:|.|.||  |..|.::|..|..:.|..:|.:..:.
Worm   660 TEMDGVEGR---QKVFLIGATNRPDIVDAAILRPGRLDKILFVDFPSVEDRVDILRKSTKNGTRP 721

  Fly   667 -QGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSS 730
             .|..:|...:.:|.::. |::|:||.||..:::|..::...:|     :..:::.:..:.|..:
Worm   722 MLGEDIDFHEIAQLPELA-GFTGADLAALIHESSLLALQARVLE-----NDESVKGVGMRHFREA 780

  Fly   731 LKRIRRSVAPQSLNSYEKWSQDYG 754
            ..|||.||.......||...:.||
Worm   781 ASRIRPSVTEADRKKYEHMKKIYG 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	21/120 (18%)
		P-loop_NTPase	482..>538	CDD:304359	23/57 (40%)
		AAA	515..652	CDD:214640	58/138 (42%)
		AAA	519..650	CDD:278434	57/132 (43%)
		Vps4_C	<722..754	CDD:286426	8/31 (26%)
mac-1	NP_496814.1	Nucleolin_bd	5..65	CDD:318849
mac-1	NP_496814.1	TIP49	<191..804	CDD:332389	149/664 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810