DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and cdc-48.1

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_496273.1	Gene:	cdc-48.1 / 174624	WormBaseID:	WBGene00007352	Length:	809	Species:	Caenorhabditis elegans

Alignment Length:	776	Identity:	186/776 - (23%)
Similarity:	296/776 - (38%)	Gaps:	219/776 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 DLTPTTCSPRSGHHHSYGGYSSSVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVI 151
            |:...|.:|    :.|||   :.:|          ::.:.:.:..|...||.:|...|....
Worm   104 DVVSITPAP----NLSYG---TRIH----------VLPIDDTIEGLTGNLFDVFLKPYFLEA--- 148

  Fly   152 YRP-HRRDC--------NIEIVVQNSSKEQQQSLNHPSELNREGD-------------------- 187
            ||| |:.|.        .:|..|..:.......::..:.::.|||
Worm   149 YRPLHKGDIFTVQAAMRTVEFKVVETEPAPACIVSPDTMIHYEGDPIKREEEEESMNDIGYDDLG 213

  Fly   188 GQEQQLS----------NQPQRFRPIQPLEMAANRPGGGY----SPGPGDPLLAKQKHHHRRAFE 238
            |..:||:          ..||.|:.|      ..:|..|.    .||.|..|:|:...:...:|.
Worm   214 GVRKQLAQIKEMVELPLRHPQLFKAI------GIKPPRGILLFGPPGTGKTLIARAVANETGSFF 272

  Fly   239 YISKALKIDEENEGHKELAIELYRKGIKELE------------DGIAVDCWSGRGDVWDRAQRLH 291
            ::....::..:..|..|..:   ||..:|.|            |.||.......|:|
Worm   273 FLINGPEVMSKMSGESESNL---RKAFEECEKNQPAILFIDEIDAIAPKREKTNGEV-------- 326

  Fly   292 DKMQTNLSMARDRLHFLALREQDLQMQRLSLKEKQKEEAQSKPQKTREPMLAGMTNEPMKL--RV 354
                                |:.:..|.|:|.:..|..:..        ::...||.|..:  .:
Worm   327 --------------------ERRIVSQLLTLMDGVKGRSNL--------VVIAATNRPNSIDGAL 363

  Fly   355 RSSGYGPKATTSAQPTASGRK--LTIGSKRPVNLA-------VANKSQ-TLPRNLGSKTSVGAVQ 409
            |..|...:......|.|.||.  |.|.:|. :.||       :||:.. .:..:|.|..|..|:|
Worm   364 RRFGRFDREIDIGIPDAVGRLEILRIHTKN-MKLADDVDLEQIANECHGFVGADLASLCSEAALQ 427

  Fly   410 RQPAK------------------TAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGASTPVV 456
            :...|                  .|.|....|  |:.|:::|.
Worm   428 QIREKMELIDLEDDQIDAEVLNSLAVTMENFR--FAQGKSSPS---------------------- 468

  Fly   457 SVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFT--GLRAPAKGL 519
                        .|.|.|.......|:||.|....|:.|||:|..|...||.:.  |:: |::|:
Worm   469 ------------ALREAVVETPNTTWSDIGGLQNVKRELQELVQYPVEHPEKYLKFGMQ-PSRGV 520

  Fly   520 LLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEV 584
            |.:||||.||||||:|:|.||.|.|::|....|.:.:.|:.|..||.:|..||...|.::|.||:
Worm   521 LFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVRDVFDKARAAAPCVLFFDEL 585

  Fly   585 DSLLSERSSSE----HEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALR--RFT 643
            ||:...|....    ..||.|:..:.|.|.||:....:   :.::.|||||..:|.|.||  |..
Worm   586 DSIAKARGGGAGGDGGGASDRVINQVLTEMDGMNAKKN---VFIIGATNRPDIIDPAVLRPGRLD 647

  Fly   644 KRVYVSLPDEQTRELLLNRLLQKQGSPLDTEA-LRRLAKITDGYSGSDLTALAKDAALEPIRELN 707
            :.:|:.||||.:|..:|...|:|  :||..:. |..|||.|.|:||:|||.:.:.|....|||..
Worm   648 QLIYIPLPDEASRHQILKASLRK--TPLSKDLDLTFLAKNTVGFSGADLTEICQRACKLAIRESI 710

  Fly   708 VEQVKCLD-----------------ISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKWSQ 751
            .::::...                 :..:..||...|..::|..||||....:..||.::|
Worm   711 EKEIRIEKERQDRQARGEELMEDDAVDPVPEITRAHFEEAMKFARRSVTDNDIRKYEMFAQ 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	12/89 (13%)
		P-loop_NTPase	482..>538	CDD:304359	27/57 (47%)
		AAA	515..652	CDD:214640	54/142 (38%)
		AAA	519..650	CDD:278434	51/136 (38%)
		Vps4_C	<722..754	CDD:286426	11/30 (37%)
cdc-48.1	NP_496273.1	CDC48_N	31..112	CDD:280513	2/7 (29%)
		CDC48	52..775	CDD:273521	186/776 (24%)
		CDC48_2	137..197	CDD:215011	13/62 (21%)
		AAA	247..376	CDD:278434	27/167 (16%)
		AAA	520..654	CDD:278434	51/136 (38%)
		Vps4_C	<727..771	CDD:286426	10/43 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810