DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spas and cdc-48.2

DIOPT Version :9

Sequence 1:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_495705.1	Gene:	cdc-48.2 / 174309	WormBaseID:	WBGene00008053	Length:	810	Species:	Caenorhabditis elegans

Alignment Length:	758	Identity:	187/758 - (24%)
Similarity:	291/758 - (38%)	Gaps:	215/758 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 YSSSVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRP-HRRDC--------NI 161
            |...||          ::.:.:.:..|...||.:|...|....   ||| |:.|.        .:
Worm   115 YGKRVH----------VLPIDDTIEGLTGNLFDVFLRPYFTDA---YRPVHKGDIFTVQAAMRTV 166

  Fly   162 EIVVQNSS----------------------KEQQQSLNHPSELNREG-DGQEQQLS--------- 194
            |..|..:.                      :|::::||   |:..:. .|..:||:
Worm   167 EFKVVETDPAPACIVAPDTVIHYEGDPIKREEEEEALN---EVGYDDLGGVRKQLAQIKEMVELP 228

  Fly   195 -NQPQRFRPIQPLEMAANRPGGGY----SPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHK 254
             ..||.|:.|      ..:|..|.    .||.|..|:|:...:...||.::....:|..:..|..
Worm   229 LRHPQLFKAI------GVKPPRGILLFGPPGTGKTLIARAVANETGAFFFLINGPEIMSKMSGES 287

  Fly   255 ELAIELYRKGIKELE------------DGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHF 307
            |..:   ||...|.|            |.||.......|:|   .:|:..::.|.:...:.|.|.
Worm   288 ESNL---RKAFAECEKNSPAILFIDEIDAIAPKREKAHGEV---EKRIVSQLLTLMDGLKTRAHV 346

  Fly   308 LALREQDLQMQRLSLKEKQKEEAQSKPQKTREPMLAGMTNEPMKL--RVRSSGYGPKATTSAQPT 370
            :.:                                 ..||.|..:  .:|..|...:......|.
Worm   347 VVI---------------------------------AATNRPNSIDGALRRFGRFDREIDIGIPD 378

  Fly   371 ASGRK--LTIGSK-----RPVNL-AVANKSQ-TLPRNLGSKTSVGAVQRQPAK------------ 414
            |.||.  |.|.:|     ..|:| .|||:.. .:..:|.|..|..|:|:...|
Worm   379 AVGRLEILRIHTKNMKLGEDVDLEQVANECHGFVGADLASLCSEAAIQQIREKMELIDLEDDTID 443

  Fly   415 ------TAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGASTPVVSVKGVEQKLVQLILDEI 473
                  .|.|....|  |:.|:::|.                                  .|.|.
Worm   444 AEVLNSLAVTMENFR--FAMGKSSPS----------------------------------ALREA 472

  Fly   474 VEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFT--GLRAPAKGLLLFGPPGNGKTLLARAV 536
            |.......|:||.|....|:.|||:|..|...||.:.  |:: |::|:|.:||||.||||||:|:
Worm   473 VVETPNTTWSDIGGLQNVKRELQELVQYPVEHPEKYLKFGMQ-PSRGVLFYGPPGCGKTLLAKAI 536

  Fly   537 ATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHE---A 598
            |.||.|.|::|....|.:.:.|:.|..||.:|..||...|.::|.||:||:...|..|..:   |
Worm   537 ANECQANFISIKGPELLTMWFGESEANVRDVFDKARAAAPCVLFFDELDSIAKARGGSVGDAGGA 601

  Fly   599 SRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYVSLPDEQTRELLLN 661
            :.|:..:.|.|.||:....:   :.::.|||||..:|.|.||  |..:.:|:.||||.:|..:..
Worm   602 ADRVINQVLTEMDGMNAKKN---VFIIGATNRPDIIDPAVLRPGRLDQLIYIPLPDEASRLQIFK 663

  Fly   662 RLLQKQGSPLDTEA-LRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQVK----CLDISA--- 718
            ..|:|  :||..:. |..|||.|.|:||:|||.:.:.|....|||....:::    ..|.||
Worm   664 ASLRK--TPLSADLDLNFLAKNTVGFSGADLTEICQRACKLAIRESIEREIRQEKERQDRSARGE 726

  Fly   719 ----------MRAITEQDFHSSLKRIRRSVAPQSLNSYEKWSQ 751
                      :..||...|..::|..||||....:..||.::|
Worm   727 ELMEDELADPVPEITRAHFEEAMKFARRSVTDNDIRKYEMFAQ 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	18/89 (20%)
		P-loop_NTPase	482..>538	CDD:304359	27/57 (47%)
		AAA	515..652	CDD:214640	54/141 (38%)
		AAA	519..650	CDD:278434	51/135 (38%)
		Vps4_C	<722..754	CDD:286426	11/30 (37%)
cdc-48.2	NP_495705.1	CDC48_N	31..112	CDD:280513
		CDC48	44..773	CDD:273521	187/758 (25%)
		CDC48_2	136..196	CDD:215011	10/62 (16%)
		AAA	246..375	CDD:278434	28/167 (17%)
		AAA	519..652	CDD:278434	51/135 (38%)
		Vps4_C	<725..769	CDD:286426	10/43 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810